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Blafar Ltd. NovaUCD Belfield Innovaton Park University College Dublin Dublin 4 Belfield Ireland Email: [email protected] Website: www.blafar.com Catalogue No. Descripton Catalogue No. Descripton HASH0101 450 kDa raw material HA, 75% SD (±10%) HAMA0101 450 kDa raw material HA, 50% SD (±10%) HASH0102 450 kDa raw material HA, 50% SD (±10%) HAMA0102 450 kDa raw material HA, 25% SD (±10%) HASH0103 450 kDa raw material HA, 25% SD (±10%) HAMA0103 450 kDa raw material HA, 10% SD (±5%) HASH0201 220 kDa raw material HA, 75% SD (±10%) HAMA0201 220 kDa raw material HA, 50% SD (±10%) HASH0202 220 kDa raw material HA, 50% SD (±10%) HAMA0202 220 kDa raw material HA, 25% SD (±10%) HASH0203 220 kDa raw material HA, 25% SD (±10%) HAMA0203 220 kDa raw material HA, 10% SD (±5%) HASH0301 110 kDa raw material HA, 75% SD (±10%) HAMA0301 110 kDa raw material HA, 50% SD (±10%) HASH0302 110 kDa raw material HA, 50% SD (±10%) HAMA0302 110 kDa raw material HA, 25% SD (±10%) HASH0303 110 kDa raw material HA, 25% SD (±10%) HAMA0303 110 kDa raw material HA, 10% SD (±5%) GelSH01 Type A Gelatn as the raw material GelMA01 Type A Gelatn as the raw material GelSH02 Type B Gelatn as the raw material GelMA02 Type B Gelatn as the raw material COL01003 Collagen Type I Soluton 3mg/mL COL02 Collagen Type I powder COL01005 Collagen Type I Soluton 5mg/mL COL01010 Collagen Type I Soluton 10mg/mL HB-PEG-10K Mw 10 kDa HB-PEG-20K Mw 20 kDa Bovine Collagen Type I Hyperbranched PEG based Mult-Acrylate (HB-PEG) Thiolated Hyaluronic Acid (HA-SH) Methacrylated Hyaluronic Acid (HA-MA) Thiolated Gelatn (Gel-SH) Methacrylated Gelatn (Gel-MA) Functonalised Hyaluronic Acid Functonalised Gelatn Bovine Collagen Type I Powder Bovine Collagen Type I Soluton Please enquire for more informaton on Blafar Ltd customised products We Design, Develop and Manufacture Functionalised Biomaterials

ˆˇ˘...˜˚˛˝˙ˆˇ˛˘ ˆ ˘ ˚ ˇ˛ˆ˝ ˝ˆ Biological Information ˆˇ ˘˙ ˘ ˚ ˇ˛ˆ˝ ˝ˆ ˙ ˘˝ ˘˙ ˘ ˚ ˇ˛ˆ˝ ˝ˆ ˜ ˜˚˛˝˙ˆˇ˛˘ ˆ ˘˙ˆ˛ ˆˇ ˘˙

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Page 1: ˆˇ˘...˜˚˛˝˙ˆˇ˛˘ ˆ ˘ ˚ ˇ˛ˆ˝ ˝ˆ Biological Information ˆˇ ˘˙ ˘ ˚ ˇ˛ˆ˝ ˝ˆ ˙ ˘˝ ˘˙ ˘ ˚ ˇ˛ˆ˝ ˝ˆ ˜ ˜˚˛˝˙ˆˇ˛˘ ˆ ˘˙ˆ˛ ˆˇ ˘˙

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Blafar Ltd.NovaUCD

Belfield Innovation ParkUniversity College DublinDublin 4BelfieldIrelandEmail: [email protected]: www.blafar.com

Catalogue No. Description Catalogue No. Description

HASH0101 450 kDa raw material HA, 75% SD (±10%) HAMA0101 450 kDa raw material HA, 50% SD (±10%)

HASH0102 450 kDa raw material HA, 50% SD (±10%) HAMA0102 450 kDa raw material HA, 25% SD (±10%)

HASH0103 450 kDa raw material HA, 25% SD (±10%) HAMA0103 450 kDa raw material HA, 10% SD (±5%)

HASH0201 220 kDa raw material HA, 75% SD (±10%) HAMA0201 220 kDa raw material HA, 50% SD (±10%)

HASH0202 220 kDa raw material HA, 50% SD (±10%) HAMA0202 220 kDa raw material HA, 25% SD (±10%)

HASH0203 220 kDa raw material HA, 25% SD (±10%) HAMA0203 220 kDa raw material HA, 10% SD (±5%)

HASH0301 110 kDa raw material HA, 75% SD (±10%) HAMA0301 110 kDa raw material HA, 50% SD (±10%)

HASH0302 110 kDa raw material HA, 50% SD (±10%) HAMA0302 110 kDa raw material HA, 25% SD (±10%)

HASH0303 110 kDa raw material HA, 25% SD (±10%) HAMA0303 110 kDa raw material HA, 10% SD (±5%)

GelSH01 Type A Gelatin as the raw material GelMA01 Type A Gelatin as the raw material

GelSH02 Type B Gelatin as the raw material GelMA02 Type B Gelatin as the raw material

COL01003 Collagen Type I Solution 3mg/mL COL02 Collagen Type I powder

COL01005 Collagen Type I Solution 5mg/mL

COL01010 Collagen Type I Solution 10mg/mL

HB-PEG-10K Mw 10 kDa HB-PEG-20K Mw 20 kDa

Bovine Collagen Type I

Hyperbranched PEG based Multi-Acrylate (HB-PEG)

Thiolated Hyaluronic Acid (HA-SH) Methacrylated Hyaluronic Acid (HA-MA)

Thiolated Gelatin (Gel-SH) Methacrylated Gelatin (Gel-MA)

Functionalised Hyaluronic Acid

Functionalised Gelatin

Bovine Collagen Type I PowderBovine Collagen Type I Solution

Please enquire for more information on Blafar Ltd customised products

We Design, Develop and Manufacture

Functionalised Biomaterials

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Page 2: ˆˇ˘...˜˚˛˝˙ˆˇ˛˘ ˆ ˘ ˚ ˇ˛ˆ˝ ˝ˆ Biological Information ˆˇ ˘˙ ˘ ˚ ˇ˛ˆ˝ ˝ˆ ˙ ˘˝ ˘˙ ˘ ˚ ˇ˛ˆ˝ ˝ˆ ˜ ˜˚˛˝˙ˆˇ˛˘ ˆ ˘˙ˆ˛ ˆˇ ˘˙

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Biological Information

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Blafar functionalised gelatin is modified from a natural protein making it particularly suited to cell culture, tissue engineering, cosmetic and medical device applications.

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Biological Information

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Biological Information Biological Information

Biological Information Biological Information

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Purity

pH

Solubility

Cytotoxicity

Applications

Grade

>98%

Neutral (6.5-7.5 after rehydration in PBS)

H2O, PBS

Biocompatible

3D cell culture scaffold, 3D bioprinting, wound healing material

R&D or GMP like

Purity

pH

Solubility

Cytotoxicity

Applications

Grade

>98%

Neutral (6.5-7.5 after rehydration in PBS)

H2O, PBS

Biocompatible

3D cell culture scaffold, 3D bioprinting, ECM substitute

R&D or GMP like

Purity

pH

Solubility

Cytotoxicity

Applications

Grade

>98%

Neutral (7.4 after rehydration in PBS)

H2O, PBS

Biocompatible

3D cell culture scaffold, 3D bioprinting, wound healing material

R&D

Purity

pH

Solubility

Cytotoxicity

Applications

Grade

>98%

Neutral (7.4 after rehydration in PBS)

H2O, PBS

Biocompatible

3D cell culture scaffold, 3D bioprinting, wound healing material

R&D

Purity

pH

>85%

2.0-3.0

Time untilGelationinitiated

Cytotoxicity

Applications

Grade

<30 min

Biocompatible

Collagen films, lyphilised Collagensponges, Collagen gels, cell culture

R&D

10 mg/ml in chilled HCL(<1mM) orchilled purified endotoxin-free water

Biocompatible

Coatings for medical devices,Collagen films and sponges,Collagen solutions and gels

R&D

Purity

pH

Solubility

Cytotoxicity

Applications

Grade

>85%

2.0-3.0

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Biological Information

Purity

pH

Solubility

Cytotoxicity

Applications

Grade

>98%

Neutral (7.4 after rehydration in PBS)

H2O, PBS, common organic solvents

Biocompatible

3D cell culture scaffold, 3D bioprinting, ECM substitute

R&D

Blafar Ltd. provides R&D grade products for use in research, we also have a clean

room facility on site and are able to provide GMP like products if required.

Blafar Hyperbranched PEG-based Multi-Acrylate Polymers (HB-PEG) are avaliable with differing molecularweight, branching degree and vinyl group content. HB-PEG possesses good biocompatibility as well as fast gelation time with thiolated polymers (HA-SH/Gel-SH). HB-PEG can be crosslinked by UV irradiation in thepresence of the photoinitiator, making it particular suitable for 3D bioprinting.

Collagen is a common component of most tissues including bones, dermis and tendon. Atelocollagen is pepsin-digested in acidic solution to remove antigenic telopeptides. Blafar’s atelocollagen type I is extracted from certified BSE/TSE-free bovine Achilles tendons and is treated to minimise viral and exdotoxin contamination.

Blafar functionalised hyaluronic acid is modified from a natural glycosaminoglycan and component of the extracellular matrix (ECM) making it particularly suited to cell culture, cosmetic and medical device.