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7/23/2019 Exocytose
1/18
Egfpmtra 9 4 @axneytnsa#
[ou`ftmnc ef`emqua ia `f caurntrfcslmssmnc#
M# Mctrniuetmnc 4 uc pau igmstnrmqua#
@f caurntrfcslmssmnc sahhaetua fu cmvafu ia sycfpsa '< znca ia enllucmeftmnc actra ;
caurncas nu actra uc caurnca at uc luse`a pfr axalp`a-#
Zgcnlca `aetrmquas at egmlmquas#
Enceapt ia trfcslattaurs 4
@axprmacea qum f parlms ia lattra ac vmiacea `f trfcslmssmnc egmlmqua < axprmacea
iNttn @nawm#
Qtm`msa ; eurs imhhracts kfmocfct ifcs euva ia `mqumia pgysmn`nomqua#
6 eur mccarv pfr snc carh vfoua
6 eur msn` ia snc carh vfoua
Eas ; eurs snct rfeenris `fmia iuca pnlpa#
@a ;la eur ast parhus pfr `a `mqumia pgysmn`nomqua prnvacfct iu 6areur#
Ygnrmqualact 4
Nc pacsa qua `a lassfoar ast `mkr ifcs `a `mqumia pgysmn`nomqua 6 at ast trfcslms ifcs `a
`mqumia pgysmn`nomqua ; pums ifcs `a eur ; orea fux pnlpas#
Nksarvftmncs 4
Utmlu`ftmnc iu carh vfoua rf`actmssalact ia hrquacea efrimfqua#
Nc nksarva of`alact uc rf`actmssalact ia `f hrquacea efrimfqua iu ;la eur#
Zrsacea iuc lassfoar imhhusmk`a `mkr fu cmvafu iuca sycfpsa#
@f `mkrftmnc iuc CY iuca stmlu`ftmnc prsycfptmqua paut tra sumva qufu trfvars ia snc
ahhat pnst,sycfptmqua#F ratacmr of`alact 4 m` axmsta ias sycfpsas `aetrmquas#
MM# @f sycfpsa 4 vmiaceas pnur uca `mkrftmnc qufctmqua 4 `axneytnsa#
@as CY snct stnebs ifcs ias vsmeu`as sycfptmquas at snct `mkrs pfr axneytnsa# Ei pfr
husmnc ia patmts enlpfrtmlacts lalkrfcfmras 'vsmeu`as nu orfcu`as- fvae `f lalkrfca
p`fslmqua#
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Vua``as snct `as vmiaceas >
$ Avmiacea hncetmncca``a 4 `mkrftmnc qufctf`a#
< `mkrftmnc pfr qufctf '6 qufctf < 6 vsmeu`a-#
Acraomstralact ia pntactma` ia p`fqua lntrmea 'ZZL- < vfrmftmnc ia pntactma` acraomstr fu
cmvafu ia `f tarlmcfmsnc pnst,sycfptmqua fu cmvafu iuca dncetmnc caurnluseu`fmra# Eatacraomstralact < rah`at ia `f `mkrftmnc iu CY#
Fu cmvafu ia `f p`fqua lntrmea 4 Fety`egn`mca fvae uc reaptaur cmentmcmqua#
Nc stmlu`a `a lntncaurnca `aetrmqualact nc acraomstra uca orfcia vfrmftmnc ia pntactma`
Enllact hfmra pnur lasurar `f qufctmt ia ln`eu`as ia CY.vsmeu`a >
Nc utm`msa `f lmernmnctnpgnrsa#
Qca `aetrnia ifcs `fqua``a nc lat uca enceactrftmnc enccua iFeg 'nu iuc futra CY-# Eatta
`aetrnia ast nuvarta nc `fpprnega ia `f tarlmcfmsnc pnst sycfptmqua n m` y f `as reaptaurs
cmentmcmquas#
Nc f vf`u qua 4
6 qufctul iFEg < 6 pfquat iacvmrnc 6: ::: ln`eu`as#
Acvmrnc 1:: lln`a#@,6 iFEg ifcs uca vsmeu`a#
Ax 4
Fpp`mqua Feg 6::lL
seglf ;#Nc hfmt pfssar uc enurfct `aetrmqua ifcs ``aetrnia at `Feg ast `mkra at vf sa hmxar sur sas
reaptaurs#
Vua` ast `flp`mtuia iu ZZLL `nrsqua `Feg ast `mkra spnctfclact >
Nc enlpfra `a rsu`tft nktacu fvae uca enurka axprmlactf` rf`msa pfr lmernmnctnpgnrsa#
Ence`usmnc nc f vf`u qua 4
6 qufctul iFEg < 6 pfquat iacvmrnc 6: ::: ln`eu`as#
Acvmrnc 1:: lln`a#@,6 iFEg ifcs uca vsmeu`a#
@as tuias fu lmernsenpa `aetrncmqua nct hnurcm `f cntmnc ia qufctf uc suppnrt
lnrpgn`nomqua 4 prauvas ia `f `mkrftmnc vsmeu`fmra#
6ra prauva 4
Ifcs uca tarlmcfmsnc pnst,sycfptmqua m` y f tnudnurs ias vsmeu`as ia lla tfm``a acvmrnc#
@f sycfpsa ast ralp`ma ia vsmeu`as sycfptmquas#
F `f dncetmnc caurnluseu`fmra `as vsmeu`as sycfptmquas sf`mocact fu cmvafu ia zncas fetmvas
pr,sycfptmquas prtas husmnccar#
;la vmiacea 4
Nc vnmt `as vsmeu`as 'nu orfcu`as- husmnccar sur `f lalkrfca p`fslmqua# 'Nc nksarva ias
hmouras ac nlof-#
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5la vmiacea 4
Yaegcmquas ia erynhrfetura#
Nc p`ncoa uc egfctm``nc ifcs uc lm`mau trs hrnmi 'trs krutf`alact- at nc efssa `egfctm``nc#
Unuvact `egfctm``nc sa efssa actra `as ; haum``ats 'acirnmt `a " hrfom`a-#
Zarlat ia vnmr `as haum``ats ia `f lalkrfca#
A < aetnp`fslmqua Z < prntnp`fsta
Nc nksarva ias trnus `acirnmt n m` y fvfmt ias prntmcas#
At nc nksarva ias prntmcas ia prnhusmnc < qum ipfssact#
Nc nksarva of`alact uc f`mocalact ia pfrtmeu`as `nrsqua `f sycfpsa cast pfs stmlu`a#
Fprs stmlu`ftmnc `aetrmqua tnudnurs f`mocalact ia pfrtmeu`as " m` y f ias trnus ifcs `f
lalkrfca fppa`s pumts 'nu pnras ia husmnc-#Eas pumts enrraspnciact fux pnras hnrls `nrs ia `f husmnc ias vsmeu`as#
seglf 5#
MMM#Axneytnsa encstmtutmva vs axneytnsa encstmtutmva#
Nc imstmcoua ; typas iaxneytnsa 4
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encstmtutmva < iua ias vsmeu`as sa hnrlfct iapums `a rsafu trfcson`omac# A``as snct
firassas vars `f lalkrfca p`fslmqua# Ea qum efrfetrmsa eatta vnma east qua``a
sahhaetua ocrf`alact vmtassa encstfcta# Enlla east uc prneassus parlfcfct nc
cnksarva pfs ia stneb ia eas vsmeu`as# F pnur hncetmnc prmcempf`alact 4 `a
racnuva``alact ias encstmtufcts lalkrfcfmras at `a racnuva``alact ia `f lftrmea
axtrfea``u`fmra# @f vmtassa iaxneytnsa cast pfs rou`a# Ea prneassus ast rou`ucmqualact pfs `f vmtassa ia syctgsa prntmqua# Lefcmsla ucmvarsa`#
[ou`a < ias vsmeu`as knuroanccact iu rsafu trfcson`omac# Nc trnuva ias stnebs ia
vsmeu`a# @as stnebs sa trnuvact ifcs `f znca fetmva pnur uca sycfpsa# Eas stnebs vnct
fttacira uc smocf` 'ax 4 hmxftmnc iuca gnrlnca sur uc reaptaur lalkrfcfmra-#
[ou`ftmnc ia `axneytnsa at ince ia `f vmtassa ia `mkrftmnc pfr ias lassfoars
mctrfea``u`fmras# Lefcmslas cnc ucmvarsa m` ast enlluc imhhracts typas ia
ea``u`as 4
, Caurncas CY
, Acinermcas gnrlncas paptmimquas
, Axnermcas `mkrftmnc iaczylas imoastmvas
, Lfstneytas gmstflmca
Fu enurs ia `axneytnsa `as vsmeu`as knuroanccact iapums `a rsafu trfcson`omac cntfllact
orea `f prsacea ia prntmcas enftflras 'enft 6 enft ; at e`ftgrmca- nc nktmact ias
vsmeu`as mllfturas < vsmeu`as ia orfcia tfm``a n `a lftrma` mctarca ast pau enciacs# Fu
hur at lasura ia `f lmorftmnc vars `f lalkrfca m` y f uc pgcnlca ia lfturftmnc fvae
enciacsftmnc iu lftrma` trfcspnrt# M` y f of`alact uca lfturftmnc kmnegmlmqua#
Ea snct eas vsmeu`as lfturas qum vnct pnuvnmr husmnccar fvas `f lalkrfca p`fslmqua at pfs
`as futras#
Zn`frmsftmnc ias lefcmslas ia `axneytnsa 4
@as lefcmslas iaxneytnsa pauvact tra pn`frmss#
K# Nc mciumt `axneytnsa a``a sa prniumt pfrtnut ifcs `f ea``u`a#
E# @axneytnsa cast ie`acega qua iu et ia `foact stmlu`fct# Axneytnsa pn`frmsa lla
sur uca ea``u`a cnc pn`frmsa#
M` paut fussm y fvnmr uca pn`frmsftmnc lnrpgn`nomqua# Ax 4 ea``u`as pmtg`mf`as#
Vuast ea qum hfmt qua `as vsmeu`as snct nrmactas vars `a p`a fpmef` nu vars `a p`akfsn`ftrf` >
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Ias squaceas prntmquas ifcs `as lalkrfcas ias vsmeu`as parlattact iacvnyar eartfmcas
vsmeu`as spemhmqualact vars `a p`a fpmef` nu vars `a p`a kfsn`ftrf`#
Ax 4 Umocfux 4 prsacea iuca tyrnsmca at . nu prsacea ia `auemcas itarlmca `nrmactftmnc
vars `a p`a kfsn`ftrf`#
Fu cmvafu fpmef` `as vsmeu`as emk`as vars `a p`a fpmef` enctmaccact ias prntmcas fcerfoa
OZM 'O`yensy` Zgnspgftmiy` Mcnsmtn`-# @a ornupalact OZM parlat `f prntmca ia sfcerar
`f lalkrfca# @as vsmeu`as enctacfct eas ornupalacts OZM snct nrmactas vars `f lalkrfca
fpmef`a#
Xars `f lalkrfca kfsn`ftrf`a 4 smocfux ifcs `f tarlmcfmsnc eytnp`fslmqua# 6- smocf`
enctacfct 6 tyrnsmca at ;- ; `auemcas fidfeactas#
Eas femias flmcs snct raenccus pfr ias prntmcas enftflras qum `as fssalk`act ifcs ias
vsmeu`as ia trfcspnrt fu cmvafu iu rsafu trfcs On`om#
Yrfhme lalkrfcfmra ifcs `f sycfpsa 4
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Enrps ea``u`fmra " sycfpsa 'enup pnur lam``aura vmsuf`msftmnc-#
Ias vsmeu`as sa hnrlact at vnct tra nrmactas vars `f lalkrfca p`fslmqua#
F pfrtmr iu rsafu trfcson`omac nc paut fvnmr ias lefcmslas iaxneytnsa encstmtutmva at ias
lefcmslas iaxneytnsa rou`a 'pnur `as caurnpaptmias at cnc `as CY-#
@as vsmeu`as qum parlattact `f `mkrftmnc ia CY prnvmaccact ias acinsnlas# Eas acinsnlas
parlattact `a knuroanccalact ia vsmeu`as sycfptmquas# Ifcs uc 6 ar talps `as vsmeu`as snct
vmias# Zums a``as snct ralp`mas at vnct pnuvnmr f`nrs husmnccar pfr axneytnsa# Lfturftmnc
A``a inmt fomr sur uc reaptaur.sacsaur.ahhaetaur#
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Umta ia hmxftmnc enup` uc `lact ia rpncsa#
[pncsa pgysmn`nomqua 'enctrfetmnc sertmnc-
Uf enceactrftmnc inmt egfcoar ia lfcmra smocmhmeftmva ac rpncsa uc futra smocf`#
Uystla pnur erftmnc at iastruetmnc iu lassfoa#
Cmvafu iu saenci lassfoar inmt egfcoar ac rpncsa uc stmlu`us cftura` at eaem
fvfct at pacifct qua `f ea``u`a rpnci#Ef`lniu`mca sacsaur Ef;"#
Zrntmca bmcfsa F sacsaur FLZe#
X# @a ef`emul enlla saenci lassfoar#
@a ef`emul paut ractrar pfr ias efcfux mncmquas at ast efpfk`a ia ie`acegar `axneytnsa#
Lfms `axneytnsa ast ipacifct iu eytnsqua`atta at `a ef`emul mctarvmact sur ia cnlkrausas
prntmcas iu eytnsqua`atta#
@a ef`emul fomt imhhracts cmvafux#
Axneytnsa at ;ci lassfoars 4 @a ef`emul stmlu`a `f sertmnc rou`a#
Nc paut egfcoar `f enceactrftmnc ac ef`emul `axtrmaur ia `f ea``u`a# Enllact paut,nc
f``ar enctr`ar `f enceactrftmnc ac ef`emul `mctrmaur ia `f ea``u`a >Nc paut utm`msar uc itaroact inux qum vf hfmra ias patmts trnus ifcs `f lalkrfca