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• les derniers brevets deposes: morceaux choisis •realisee en collaboration avec I'inpi
AGRICUl TUREAGROINDi lSTRIE
Productionsvegetales
> Gene de I'hydroxy-phenyl pyruvate dioxygenaseet obtention de plantescontenant ce gene resistantes aux herbicides (ASailland et ai, FR)RhOne-Poulenc Agrochimie
N" 2734841, FR.
> Improvements in or relating to plant starchcomposition (0 Cooke etai, UK)National Starch and Chemical Investment HoldingCorp and the inventors
N" WO 96/34968, PCT.... a nucleotide sequence encoding an effective portionof a class A starch branchingenzyme (SBE) obtainablefrom potato plants, or afunctional equivalent thereof, together with, interalia, a corresponding polypeptide, a method of altering the characteristics of aplant, a plant having alteredcharacteristics; and starch,particularly starch obtainedfrom a potato plant, havingnovel properties.
> An enzyme with exochitinase activity (H Oraborgand S Christgau, OK)Novo Nordisk A/S and theinventors
N°WO 96/36700, PCT.The invention relates to aDNA construct comprisinga DNA sequence encodingan enzyme exhibiting exochitinase activity, whichDNA sequence shown inSEQ ID No 1 or SEQ IDNo 3, or analogues of theDNA sequences encodingpolypeptides which are derived from SaccharomycescerevisiaeDSM No 9944 orS cereviseae DSM No 9945.
> Method for reproducingconifers by somatic embryogenesis using a maltose enriched maintenancemedium (PK Gupta, US)Weyerhaeuser Co
N°WO 96/37097.
> Corn rootworm controlvia formation of Iimonene
in transgenic plants (TEMeyer, US)Pioneer Hi-Bred Internationallnc
N" WO 96/37102, PCT.Limonene is effective incontrolling Southern cornrootworm. It can be appliedas a conventional insecticide,or plants can be transformedwith a gene which codes foran enzyme which synthesizeslimonene from a substrateavailable in the plant. Transformed plants are resistantto infestation by Southerncorn rootworm.
> Gene controlling senescence in plants (H Thomaset ai, UK,AU)Germinal Holdings Ltd andthe inventors
N" WO 96/37613, PCT.... so-called «stay-green»mutation of a gene controlling leaf senescence in aplant species, add the use ofthe nucleotide sequencescomprising or derived fromthis gene mutation in recombinant DNA technologyin the production of noveland improved plant variantsfor use in identifying strainsproduced in conventionalplant breeding which havethe mutation.
> Procedl! de mise en evidence de microorganismes thermoresistantspouvant contaminer certaines denrees alimentaires (E Chrzavzez, FR)Ultra Propre Nutrition Industrie Recherche (Unir)
N" 2734844, FR.... precedepermettant la miseen evidencede Byssochlamysniuea, Neosartorya fischeriet Zygosaccharomyces bailiipar amplification de l'ADNgenomique des microorganismes cibles en utilisantcomme amorce une sequencecomprise dans les espaceurstranscrits internes (ITS) del'unite ribosomique.
SANTEProte lne s
et peptides
> Helicobacter polypeptides, their production anduse (T Sugiyama etai, JP)Wako Pure Chemical Industries Ltd
N°745674, EP.... amino acid sequences ofpolypeptides reacting withantibodies to Helicobacterpylori, DNAs coding therefor, vectors containing saidDNAs, transformantscontaining said vectors ...
> Human neuropeptide receptor (DRSoppet and CARosen, US)Human Genome SciencesInc
N" WO 96/34877, PCT.... methods for utilizing suchpolypeptides for identifyingantagonists and agonists tosuch polypeptides and methods of using the agonistsand antagonists therapeutically to treat conditions related to the underexpressionand overexpression of theneuropeptide receptor polypeptides, respectively.
> Biologically active peptide fragments of ob protein (RA Smith et ai, UK)Smith kline Beecham pic
N" WO 96/34885, PCT.... protein fragment of the obprotein, being an active siteof said protein, the active siteis formed from one or moreamino acids selected fromone or more of the four helices forming the secondarystructure of the og protein.The compounds are considered to be capable of regulating the physiological activity of the ob protein andare therefor of potential usein the treatment of nutritional and metabollic disorders,particularly obesity and diabetes in the case of agonistsand anorexia and cachexiain the case of antagonists.
> Nucleic acids for treating obesity (KW Giese, LTWilliams, US)Chiron Corp
N" WO 96/35787, PCT.A nucleic acid molecule isprovided that can be expressed in a host cell to produce a biologically active obpolypeptide that can effectively inhibit food intakeand/or weight gain. Vectorsand host cells containing thenucleicacid moleculeare alsoprovided, as well as methodsfor producing the ob proteinand other ob polypeptides,methods of induction of the
production of the ob polypeptides, such as by in vivoor ex vivo gene therapy.
> Transgenic animal models for Type II DiabetesMellitus (MD Carty et ai,US)Pfizer Inc and the inventors
W WO 96/37612, PClThe DNA construct allowspancrea tic ~ cell-specificexpression of human islet associated polypeptide (lAPP)under the regulation of therat insulin II promoter inboth cell lines and transgenic animals. The tra.nsgenicanimals develop amyloidplaque deposits in the isletsof Langerhans in the pancreas, fasting hyperglycemia,glycouria and diabetic glomerulosclerosis at 3 to' 5months of age.
> Antisense peptides (ADMiller and JG Raynes, UK)Imperial College ofScience, Technology & Medicine, London School ofHygiene and Tropical Medicine and the inventors
N°WO 96/34887, PCT.Antisense peptides are provided which are useful in antagonising the biological effects of target molecules. Inparticular, the target molecule is a cytokine, eg IL-laor IL-l~, TNF-a or IL-8 andthe antisense peptides thusfind use in treating or preventing conditions mediatedby these cytokines, for instance inflammatory conditions or cancer.
Vaccins
> Composition vaccinaleIiquide et procede de fabrication (FArminjon et ai,FR)Pasteur Merieux Serums etVaccins
N" 2734484, FR.... comprenant au moins unantigene constitue par unpolysaccharide capsulaire debactcrie couple aune proteine tetanique ainsi que descomplexes d'aluminium atitre d'immuno-adjuvant.
> Marek's disease vaccine(HE Spikers and JJ Louwerens, NL)Duphar International Research BV
BIOFUTUR 164 • Fevrier 199743
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