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f, o s s ri U s i ul sh ri I c u dr sSAWANPRACHARAK MEDICAL JOURNAL
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z. nr:dr.r6.rronen:1n lfrldrndoqnul urf,{orro rfl unururnr Inol#nuru rar [email protected]^Z3nfl:ulonrnrol.loilouourr:n rravFa{dolilnluo]d'u rrci6r6o{nrr5r,:o.tofi
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3. r0nffi :dmdqilrn rfl u?t:fll:n1u16lnqu lfi #dotjorl:dt:n1xfi fi{floIndex Medicus
fra o rirq nr:tfi su uvr ffad o u ron gruuuuluri (Structured abstract)
unfiotiourn:lruuuulmrirfluuvrfintiuduanl6o{unoutunr:iinurifrtllnoall drulfi
cirurflrloiruuashinnndu rdorr'ltnlurhfrqProblem/background : ilalnr/ nrqHa'ustnr:rfiii'u
Research question/objective : tiltfiutu/fitntu
Setting
Research design
Patients/material
Methods (intervention/
measurement/ statistics)
Results
Conclusion
Key words
6aodrqqradlru
lrllfio ti oulluf 9lltslrllLimpaphayom K, Taechakraichana N. Poshyachinda M, Jaisamran U' Effect of horrronal
replacement therapy on bone changes in Thai menopausal women : a preliminary reports'
Chula Med J tgs+ Nov ; sa (tr) : 6?9-87.
: il:vrnnl:otorutn/ndiln: Case report, retrospective, prospective, randomized fiial
: nr:fint6on{:JatlTfrninoao.rd oau e a , ..3+: lBnr:vtrllu,lnnattnu2tn:lslllll{flon
: flaRT6inul
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To study the effect of hormonal replacement therapy on bone changes.
Me,lropause Clinic Deparfinent of Obsterics and Gynecology, Faculty of Medicing
Chulalongkorn UniversitY.
Prospective, randomized studY
One hundred and thirfy seven premenopausal and postmenopausal women with
age range of aO-gZ (mean J SD = 48.A? + ?.65) years were recruited into the
study. Women in the study group (ZZ /tZt) used estrogen replacement therapy
either with or without progestogen. The control group (oO/tez) did not use
hormonal regimens.
Bone mass densrry was measured at bottl lumbar spines and hips in each clients
with Dual Energy X-ray Absorptiometry (DE)G) at 0 and 6 months.
There were no significant difference in bone changes between the study group
(Lumbar spines : 0.48 + o,7O%; Hips : o.oo t L,76oh) and the control group
(l-umbm spines | 2,97 t t.zgqo; Hips : 1.37 + t.*sqb) in the first six-month of
bone monitoring. Nevertheless, when considered into the surgical menopausal
women, it showed that ftere was terde,ocy of gfeater bore loss in tb nsr-trunronal
grcup (Imbar spines : o.aa J O.lWo iHips : 0.6S t l.?8o/") than in the hormond
rreated group (Lurnbar : -1.?o ! o.za{o; Hips i -?-8 ! o.As/o), though there was
no statistically sigfficant difference.
Objective
Setting
Desigr
Subjects
Meftod
Results
\
Conclusion : The preliminary results showed some beneficial effects of hormonal replacement
trerapy (IRT) in slowing bone loss eryecially in ttre grurp of urgical rnenoeausal,
any further long term effect of HRT in other group of menopausal wornen will
be followed.
Key words : Hormonal replacement therapy, Bone changes.
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ddnurfl, Index Medi"us qnit r,rtolurlu'lry 6 nwp:11www.nlm.nih.gov/tsd/serials/liji.html
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z. Parkin DM, Clayton D, Black RJ, Masuyer E, Friedl HP, lvanov E, et al. Chidhood
leukaemia in Europe after Chernobyl : o year follow-up. Br J Cancer 1996 ; ?a : 1006-12.
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t. Cancer in South Africa (editorial). S Afr Med J 1ee4 ; 84 : lb.
r.l unnuuluqriuuilrnau u Ul a I y s er. ifru fru'ln6n:. fuurnfiou Inrurnr:fiuq{n1il. 1u : au#u u'ufinn', roiu nollfi'a, ur:otl;nr:.ntrnenifuu?ndou. ar:fi?:u 25Be ; +a (nriunu?R) : 168-0r.
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rroanosodfruqffiu.rquufio{ouu (umu::on?nr:), crr:fi?na z6ss ; 4s : 616-20.
z Enzensberger W, Esche" PA. lvletonome in Parkinson' s disease (ar"). Iflreet 1996 ; &1? : tgg?.se c 4l2. fiU{fiO nlfl ?ttotlu{lil
JAloJooat-)^t?1. ruo{llvtuvt : ilrunililil : l]riilrr{.
- nrhiilousisloru{firu#vcz-tta
1. f{1U dUn?{U, OitnR1ttlaCfll:U:filIliutilu?flu]illuI ; 2635.
oriuuriltrJiurll. f,ur(nird ?. nl{rililu?r'ruR: :
2. Ringsven MI! Bond D. Gerontology and leadership skills for nurses. znd ed" Albany (lfY) t
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z.z unmd'rlunrhitar,riioeir:r-r-:r^.d A^v-s-.- .t A^.d--q- c- d------ . q I o { J l- rnloilil. loryuilutr, roHo{lu.,lu : Tourtorlfinu, u::onfnr:. io?ru{ala. nt{fifiurl.dl-
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il:yo: u?enr"1:'r, finn 6:6qIq, il:rulinl:. Qx1:r2, a"nai. f,r,r,(ni.:fi 2. nl{rlryrul,rlunr :AraJ9l:outtR?R1:Tuty{ i 2640. t1u1 424-7.
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loJos-ranlolnfluyl : illuR?IUyt ; uililuil.A .{a JllJolllltrtlltl :ulaaloa
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z. Kaplan SJ. Post-hospital home health care : the elderly, s access utilization (dissartation).
SL Louis (MO) : Washington Univ. ; 1ee5.io lA6. o{fluytoucl
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