BACK

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β

β

β

β

β

β

β

Δ β

β β

β

β

BACK

on

offmyeloid

(pre)BCR

Notch1

M-CSFR

VH-DJH

BLNK

CD19

Pax5

Ig

lineage-inappropriate genes

B-cell-specific genes

MPOT-lymphoid off

signaling

A BIgH+/+

IgHPax5/Pax5 IgHPax5/Pax5

BACK

β

α

BACK

BACK

BACK

BACK

BACK

α

transcriptional repression

shRNAs ?

X inactivation

Me Ac?

Xist

Me

Me

DNA methylation

Me Me

Me

MeMe

Me

AcHP1Me

Dnmt3b

heterochromatin formation

???

MeMeMe

MeMe Me

PC

PcG silencing

MeMe

Me

MeMe

MeMe MeMeMeMe HP1Me

HP1

MeHP1 MeHP1

Me

Rb

BACK

BACK

α

αα

α

α

αα

α−

A

wildtype

B

C

D

-adaptin

pIIa pIIa

numbwildtype

pIIa pIIb

-adaptin

pIIa pIIa

Notch

pIIb pIIb

-AdaptinNumb

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over-expressionknock-out

brain functions

osteosarcomasosteopetrosis, “op”

activity “op” (arrow)

myosarcomas

Fosconditional

Fos / Fos / Fos brain

Fos-/- p53-/- Fos+

wtwt Fos-/-

wt

brainbone

Fra-1fetus

over-expressionknock-out

conditionalknock-out

Fra-1 replaces Fosviable, but osteopenic

osteosclerosislethality at E9.5

Jun

scoliosislethality at E12.5

cartilageknock-out

liverskin

viable, eye-closuredefect

viable, regenerationdefect

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BACK

*

16

8

20

12

28

24

32

40

36

x 1000 reactions

4

96 97 98 99 00 01 02 03

44

A B C0.005% 6.2% 97%

R1 R1 R1

FITC

PE

FITC

PE

FITC

PE

BACK

/

/

H3-

K9

G9aSuv39h

0

20

40

60

80

unmod. mono di tri

%

0

20

40

60

80

unmod. mono di tri

%

BACK

α

BACK

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BACK

BACK

BACK

BACK

BACK

BACK

BACK

BACK