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Insights in Life Science
Responsables :
Andréa DUMOULIN et Mariano CASADO (MC ENS) pour l’équipe enseignante et Hind
BABA AISSA (Spibens)
Objectif et description du cours :
L’enseignement est organisé autour de "micromodules" présentés par des membres de
SPIBEns (SPIBEns = Students and Postdocs of the Institut de Biologie de l’Ens). Chaque
année, SPIBEns propose 10-12 micromodules. Il s’agit de sujets de Biologie ou applicables à
la Biologie, validés par l’équipe enseignante du Département. Le contenu de ces
micromodules est complémentaire de l’offre d’enseignements existants. Un membre de
l’équipe enseignante assure la cohérence entre les différents enseignements. Le choix des
micromodules à suivre par les étudiants est entièrement libre. Chaque micromodule aura une
durée de 3 x 1 heure et portera sur un sujet au choix et de la spécialité de l’intervenant.
Planning : 12h30 à 13h30 un jour par semaine, souvent trois semaines d’affilées. Le jour sera
fixé pour chaque cours, indépendamment des autres.
Évaluation :
Diplôme de l’Ens (DENS). Chaque micromudule sera évalué indépendamment. Cette
évaluation aura des formats variés mais de préférence légers (QCM, rapport écrit...).
Pour valider l’ensemble du module "Insights in Life Sciences by SPIBens" les étudiants
devront suivre et valider 5 micromodules pour une valeur totale de 3 ECTS. La validation du
module peut se faire sur 1, 2 ou 3 ans.
Par ailleurs, tout étudiant a le droit de suivre et de valider des micromodules sans
nécessairement chercher à valider le module (mais dans ce cas, aucun ECTS ne sera crédité).
Programme pour le premier semestre 2018-19:
Richard Dorrell : 19 octobre au 9 novembre
Magali Hennion : 8 au 29 novembre
Olivier Gemin : 16 au 30 novembre
Juan Jose Pierella Karlusich : 7 au 21 décembre
Guillaume Louvel : 6 au 20 décembre
MAJ 12/10/18
Micro Name: Richard Dorrell Lab: Bowler Email: [email protected] Micro-module title: Eukaryotic evolution: origins and functions of the other 99%Micro-module format: 3 x 1h lecture + 1h exam. I also normally offer a 1h tutorial for small groups of students after the final lecture, in case they have any questions. Exam/evaluation format (preferentially, NOT a paper presentation)essay, title given out a few days in advance to the students so they can plan, essay can be in English or French) Preferred weeks/months/semesterOctober 19th, October 26th, November 9th Additional resources required (ie. Computer Maximum number of students (if applicable): Minimum number of students you are willing to give the course Open this course to all IBENS personnel: Yes Language of Instruction: English (lectures), either language goes for tutorials or exam Outline of lectures (one paragraph): Animals, plants and fungi only rediversity of algal and protist lineages known. Recent genome sequencing projects for eukaryotes have provided valuable insights into the biology of many environmentally and economically important organisms. This module will explore the full diversity of eukaryotes, with a particular focus on photosynthesis. First, we will explore the eukaryotic tree of life in detail. Next, we will discuss how genome sequencing has transformed our understandinwe will look at the fundamental processes that underpin the gain, loss, and endosymbiotic replacement of chloroplasts. The students will gain a thorough understanding of eukaryotic diversity, and insights into some of thcellular level.
Insights in Life Sciences
Micro-module Proposal Form
Eukaryotic evolution: origins and functions of the other 99%3 x 1h lecture + 1h exam. I also normally offer a 1h tutorial for small
groups of students after the final lecture, in case they have any questions.
(preferentially, NOT a paper presentation): written exam (1h timed essay, title given out a few days in advance to the students so they can plan, essay can be in
/months/semester and times (lunch time or at 6-7 pm) : October 19th, October 26th, November 9th
Additional resources required (ie. Computer, lab): projector for powerpoint
Maximum number of students (if applicable):
Minimum number of students you are willing to give the course to:
Open this course to all IBENS personnel: Yes
English (lectures), either language goes for tutorials or exam
Outline of lectures (one paragraph):
Animals, plants and fungi only represent a small fraction of the tree of eukaryotes, with a vast diversity of algal and protist lineages known. Recent genome sequencing projects for eukaryotes have provided valuable insights into the biology of many environmentally and
ant organisms.
This module will explore the full diversity of eukaryotes, with a particular focus on photosynthesis. First, we will explore the eukaryotic tree of life in detail. Next, we will discuss how genome sequencing has transformed our understanding of eukaryotic evolution. Finally, we will look at the fundamental processes that underpin the gain, loss, and endosymbiotic replacement of chloroplasts. The students will gain a thorough understanding of eukaryotic diversity, and insights into some of the major questions about how eukaryotes operate at a
Eukaryotic evolution: origins and functions of the other 99% 3 x 1h lecture + 1h exam. I also normally offer a 1h tutorial for small
written exam (1h timed essay, title given out a few days in advance to the students so they can plan, essay can be in
English (lectures), either language goes for tutorials or exam
present a small fraction of the tree of eukaryotes, with a vast diversity of algal and protist lineages known. Recent genome sequencing projects for eukaryotes have provided valuable insights into the biology of many environmentally and
This module will explore the full diversity of eukaryotes, with a particular focus on photosynthesis. First, we will explore the eukaryotic tree of life in detail. Next, we will discuss
g of eukaryotic evolution. Finally, we will look at the fundamental processes that underpin the gain, loss, and endosymbiotic replacement of chloroplasts. The students will gain a thorough understanding of eukaryotic
e major questions about how eukaryotes operate at a
MAJ 12/10/18
Micro Name: Magali Hennion Lab: Hyrien - Eukaryotic Chromosome ReplicationEmail: [email protected] Micro-module title: High-throughput sequencing? Sure! But what for?Micro-module format: 3 x 1h lecture + 1h exam Exam/evaluation format (preferentially, NOT a paper presentation): written exam Preferred weeks/months/semester and times (lunch time or at 6November 8th, November 15th, Additional resources required (ie. Computer, lab): Maximum number of students (if applicable): Minimum number of students you are willing to give the course to: Open this course to all IBENS Language of Instruction: English Outline of lectures (one paragraph): Overview of DNA sequencing technologies. I will show how they have revolutionized the molecular biology, with examples in genomics, epigenomics and transcriptomics. The last part of the course will be focused on the use of these technologies in the DNA repfield.
Insights in Life Sciences Micro-module Proposal Form
Eukaryotic Chromosome Replication
Email: [email protected]
throughput sequencing? Sure! But what for? 3 x 1h lecture + 1h exam
Exam/evaluation format (preferentially, NOT a paper presentation): written exam
Preferred weeks/months/semester and times (lunch time or at 6-7 pm) : r 8th, November 15th, November 22nd, November 29th.
Additional resources required (ie. Computer, lab):
Maximum number of students (if applicable):
Minimum number of students you are willing to give the course to:
Open this course to all IBENS personnel: No
English
Outline of lectures (one paragraph):
Overview of DNA sequencing technologies. I will show how they have revolutionized the molecular biology, with examples in genomics, epigenomics and transcriptomics. The last part of the course will be focused on the use of these technologies in the DNA rep
Exam/evaluation format (preferentially, NOT a paper presentation): written exam
Overview of DNA sequencing technologies. I will show how they have revolutionized the molecular biology, with examples in genomics, epigenomics and transcriptomics. The last part of the course will be focused on the use of these technologies in the DNA replication
MAJ 12/10/18
Micro Name: Olivier GEMIN Lab: Triller Email: [email protected] Micro-module title: The wondrous little world of electron microscopy : all you want to know about the Nobel Prize 2017 in ChemistryMicro-module format: 3 x 1h lecture Exam/evaluation format (preferentially, NOT a paper presentation)Written exam (30min during the last course) Preferred weeks/months/semesterNovember 16th, November 23rd, Nov Additional resources required (ie. ComputerNone needed, thx. Maximum number of students (if applicable):~10 Minimum number of students you are willing to give the course to:3 Open this course to all IBENS personnel: Uh.., OK ! Language of Instruction: English/French, depending on the students Outline of lectures (one paragraph): Electron Microscopy (EM) is the most resolutiveyielding exquisitely detailed images of cellular ultrastructure. Recent technical developments have enabled electron microscopists to record protein structures with nearto reconstruct entire neuronal architectures with nanometric resolution, and even to make peace with light microscopists.In this micro-module, I will present the basic principles of EM, comment on the diversity of technologies it gets involved in, and dwell on a few of its fabulousciences.
Insights in Life Sciences Micro-module Proposal Form
The wondrous little world of electron microscopy : all you want to Prize 2017 in Chemistry
3 x 1h lecture
(preferentially, NOT a paper presentation): Written exam (30min during the last course)
/months/semester and times (lunch time or at 6-7 pm) : er 16th, November 23rd, November 30th.
Additional resources required (ie. Computer, lab):
Maximum number of students (if applicable):
Minimum number of students you are willing to give the course to:
IBENS personnel: Uh.., OK !
English/French, depending on the students
Outline of lectures (one paragraph):
Electron Microscopy (EM) is the most resolutive imaging technique available in biology, yielding exquisitely detailed images of cellular ultrastructure. Recent technical developments have enabled electron microscopists to record protein structures with near
onal architectures with nanometric resolution, and even to make peace with light microscopists.
module, I will present the basic principles of EM, comment on the diversity of technologies it gets involved in, and dwell on a few of its fabulous applications in life
The wondrous little world of electron microscopy : all you want to
imaging technique available in biology, yielding exquisitely detailed images of cellular ultrastructure. Recent technical developments have enabled electron microscopists to record protein structures with near-atomic resolution,
onal architectures with nanometric resolution, and even to make
module, I will present the basic principles of EM, comment on the diversity of s applications in life
MAJ 12/10/18
Micro Name: Juan José Pierella KarlusichLab: Génomique des Plantes et Diatomées (Chris Bowler)Email: [email protected] Micro-module title: Microbial Micro-module format: 3 x 1h lecture Exam/evaluation format (preferentially, NOT a paper presentation): Practical exercises to resolve at home. Preferred weeks/months/semester and timesDecember 7th, 14th, 21st. Additional resources required (ie. Computer, lab): Maximum number of students (if applicable): Minimum number of students you are willing to give the course to: Open this course to all IBENS Language of Instruction: English Outline of lectures (one paragraph):The majority of microbes in many environments are considered “as yet uncultured” and were traditionally considered inaccessible for study through the microbiological gold standard of pure culture. The emergence of metagenomic approaches has allowed researcaccess and study these microbes in a cultureof environmental samples. This microtheir analytical tools and the main metagenomic projects that are currently
Insights in Life Sciences
Micro-module Proposal Form
Juan José Pierella Karlusich
Lab: Génomique des Plantes et Diatomées (Chris Bowler) Email: [email protected]
metagenomics: beyond the genome
3 x 1h lecture or 3 x 1h lecture + 1h exam
Exam/evaluation format (preferentially, NOT a paper presentation): Practical exercises to
Preferred weeks/months/semester and times (lunch time or at 6-7 pm) :
Additional resources required (ie. Computer, lab): -
Maximum number of students (if applicable): -
Minimum number of students you are willing to give the course to: -
Open this course to all IBENS personnel: Yes or No
English
Outline of lectures (one paragraph): The majority of microbes in many environments are considered “as yet uncultured” and were traditionally considered inaccessible for study through the microbiological gold standard of pure culture. The emergence of metagenomic approaches has allowed researcaccess and study these microbes in a culture-independent manner through DNA sequencing of environmental samples. This micro-module describes the principles of metagenomics, their analytical tools and the main metagenomic projects that are currently
Exam/evaluation format (preferentially, NOT a paper presentation): Practical exercises to
The majority of microbes in many environments are considered “as yet uncultured” and were traditionally considered inaccessible for study through the microbiological gold standard of pure culture. The emergence of metagenomic approaches has allowed researchers to
independent manner through DNA sequencing module describes the principles of metagenomics,
carried out.
MAJ 12/10/18
Micro Name: Guillaume LOUVEL
Lab: DYOGEN (Hugues Roest Crollius), Section Génomique FonctionnelleEmail: [email protected] Micro-module title: Untwist the branches: how to testMicro-module format: 3 x 1h lecture Exam/evaluation format (preferentially, NOT a paper presentation): computer Preferred weeks/months/semester and times (lunch tiDecember 6th, 13th, 20th. Additional resources required (ie. Computer, lab): Maximum number of students (if applicable): Minimum number of students you are willing to give the course to: Open this course to all IBENS personnel: Language of Instruction: English/French Outline of lectures (one paragraph): In regular statistical testing, data points are often treated as independent. (evolutionary) biology, due to common ancestry, a group of related organisms can rarely be considered as all independent. Some share a longer common history than others (scoop). In that case it can be difficult to disentangle between the cof phylogenetic inertia. For example, one might ask whether primate brain size is rather caused by diet, or by sociality. Taking data from all primate species independently would lead to overestimate the number of where there is only an effect of relatedness. This course aims at progressively introducing basic to more elaborate methods of phylogenetic testing: sisterfisher exact test for testing the correlation between two discrete traits, methods that account for branch lengths, phylogenetic independent contrasts, phylogenetic regression, parametric methods modeling the underlying trait evolution, methods comparing a trait with diversification dynamics, etc. Existing bioinformatics tools (for example in R) will be presented.
Insights in Life Sciences
Micro-module Proposal Form
DYOGEN (Hugues Roest Crollius), Section Génomique [email protected]
Untwist the branches: how to test correlations on a phylogeny?3 x 1h lecture or 3 x 1h lecture + 1h exam
Exam/evaluation format (preferentially, NOT a paper presentation): exercises on paper and
Preferred weeks/months/semester and times (lunch time or at 6-7 pm) :
Additional resources required (ie. Computer, lab): One session in the computer room
Maximum number of students (if applicable):
Minimum number of students you are willing to give the course to:
Open this course to all IBENS personnel: Yes or No
English/French
Outline of lectures (one paragraph):
In regular statistical testing, data points are often treated as independent. Unfortunately in (evolutionary) biology, due to common ancestry, a group of related organisms can rarely be considered as all independent. Some share a longer common history than others (scoop). In that case it can be difficult to disentangle between the correlation of interest, or just an effect of phylogenetic inertia. For example, one might ask whether primate brain size is rather caused by diet, or by sociality. Taking data from all primate species independently would lead to overestimate the number of degrees of freedom, and finding significant relationship where there is only an effect of relatedness. This course aims at progressively introducing basic to more elaborate methods of phylogenetic testing: sister-clade method, a derived
or testing the correlation between two discrete traits, methods that account for branch lengths, phylogenetic independent contrasts, phylogenetic regression, parametric methods modeling the underlying trait evolution, methods comparing a trait with
fication dynamics, etc. Existing bioinformatics tools (for example in R) will be
DYOGEN (Hugues Roest Crollius), Section Génomique Fonctionnelle
correlations on a phylogeny?
exercises on paper and
One session in the computer room
Unfortunately in (evolutionary) biology, due to common ancestry, a group of related organisms can rarely be considered as all independent. Some share a longer common history than others (scoop). In
orrelation of interest, or just an effect of phylogenetic inertia. For example, one might ask whether primate brain size is rather caused by diet, or by sociality. Taking data from all primate species independently would
degrees of freedom, and finding significant relationship where there is only an effect of relatedness. This course aims at progressively introducing
clade method, a derived or testing the correlation between two discrete traits, methods that account
for branch lengths, phylogenetic independent contrasts, phylogenetic regression, parametric methods modeling the underlying trait evolution, methods comparing a trait with
fication dynamics, etc. Existing bioinformatics tools (for example in R) will be
MAJ 12/10/18
MAJ 12/10/18
Micro Name: Elena Kazamia Lab: Chris Bowler Email: [email protected] Micro-module title: The ocean microbiome: soup or symbiosis? Micro-module format: 3 x 1h lecture + 1h exam Exam/evaluation format (preferentially, NOT a paper presentation)Written essay Preferred weeks/months/semesterSecond semester, 6-7pm. Definitely not October-November Additional resources required (ie. Computernone Maximum number of students (if applicable):N/A Minimum number of students you are willing to give the course to:N/A Open this course to all IBENS personnel: Language of Instruction: English Outline of lectures (one paragraph):This mini lecture series will cover questions that are fundamental to the study of micecology of the ocean. Can microbes in discrete packets of water be said to interact? Do they live in structured communities where is there is an exchange of metabolites, flow of energy and distinct trophic relationships? Or is the microbial communitfluctuating with the fluid environment and currents that define this waterwill give a broad introduction to these questions at a scale that is meaningful to the ocean the largest continuous biome on earth,eco-evolutionary dynamics.
Insights in Life Sciences Micro-module Proposal Form
The ocean microbiome: soup or symbiosis?
3 x 1h lecture + 1h exam
(preferentially, NOT a paper presentation):
/months/semester and times (lunch time or at 6-7 pm) :
November
Additional resources required (ie. Computer, lab):
Maximum number of students (if applicable):
Minimum number of students you are willing to give the course to:
Open this course to all IBENS personnel: Yes or No
English
Outline of lectures (one paragraph): This mini lecture series will cover questions that are fundamental to the study of micecology of the ocean. Can microbes in discrete packets of water be said to interact? Do they live in structured communities where is there is an exchange of metabolites, flow of energy and distinct trophic relationships? Or is the microbial community unstructured and variable, fluctuating with the fluid environment and currents that define this water-based ecosystem? I will give a broad introduction to these questions at a scale that is meaningful to the ocean the largest continuous biome on earth, covering principles of oceanography, metabolism and
This mini lecture series will cover questions that are fundamental to the study of microbial ecology of the ocean. Can microbes in discrete packets of water be said to interact? Do they live in structured communities where is there is an exchange of metabolites, flow of energy
y unstructured and variable, based ecosystem? I
will give a broad introduction to these questions at a scale that is meaningful to the ocean – covering principles of oceanography, metabolism and
MAJ 12/10/18
Micro Name: Lionel Schiavolin Lab: RRI (Navarro’s team) Email: [email protected] Micro-module title: Role of bacteriophages in hostMicro-module format: 3 x 1h lecture Exam/evaluation format (preferentially, NOT a paper presentation) Preferred weeks/months/semesterSecond semester during lunchtime Additional resources required (ie. Computer Maximum number of students (if applicable): Minimum number of students you are willing to give the course to: 5 Open this course to all IBENS personnel: No Language of Instruction: French (preferably) or English Outline of lectures (one paragraph): Bacteriophages, or phages, are virusevolution of their host. They are grouped into two categories according to their life cycle. Temperate (or lysogenic) phages are able to stably integrate their DNA into the host genome as a ‘prophage’, being transmitted vertically. Occascan be reactivated to enter into a lytic cyclethe environment, usually after host cell lysis. In contrast, lytic phages are restricted to the lytic cycle and cannot integrate into the host genome. confer increased fitness to itsprotection against superinfection by Moreover, increasing studies are demonstrating thatindependently of their encoded you an overview of how these prophages take part to virulence of current lifpathogens and the re-emergence of infectious diseases.
Insights in Life Sciences Micro-module Proposal Form
Email: [email protected]
bacteriophages in host-pathogen interaction3 x 1h lecture
(preferentially, NOT a paper presentation): to determine
/months/semester and times (lunch time or at 6-7 pm): uring lunchtime
Additional resources required (ie. Computer, lab): none
Maximum number of students (if applicable):
Minimum number of students you are willing to give the course to: 5
Open this course to all IBENS personnel: No
French (preferably) or English
Outline of lectures (one paragraph):
Bacteriophages, or phages, are viruses infecting bacteria and are key players in the evolution of their host. They are grouped into two categories according to their life cycle. Temperate (or lysogenic) phages are able to stably integrate their DNA into the host genome as a ‘prophage’, being transmitted vertically. Occasionally, in response to
enter into a lytic cycle. They produce progeny that is then released in after host cell lysis. In contrast, lytic phages are restricted to the
ntegrate into the host genome. As a prophage, a temperate phage canits host, e.g. through expression of phage-encoded
superinfection by other phages, which allow its maintenance over time. ver, increasing studies are demonstrating that prophages also play
independently of their encoded toxins to promote virulence. In this lecture series, I will give you an overview of how these prophages take part to virulence of current lif
emergence of infectious diseases.
pathogen interaction
to determine
key players in the evolution of their host. They are grouped into two categories according to their life cycle. Temperate (or lysogenic) phages are able to stably integrate their DNA into the host genome
in response to stress, prophages progeny that is then released in
after host cell lysis. In contrast, lytic phages are restricted to the , a temperate phage can
encoded toxins and/or maintenance over time.
play pivotal function In this lecture series, I will give
you an overview of how these prophages take part to virulence of current life-threatening
MAJ 12/10/18
Micro Name: Vinko Besic Lab: Bacterial infection and RNA destiny (BIRD)Email: [email protected] Micro-module title: Molecular Micro-module format: 3 x 1h lecture Exam/evaluation format (preferentially, NOT a paper presentation)Questions Preferred weeks/months/semesterMarch-April 2019 Additional resources required (ie. Computer Maximum number of students (if applicable): Minimum number of students you are willing to give the course to:1 Open this course to all IBENS personnel: Language of Instruction: English Outline of lectures (one paragraph): This course is a short introduction on the use of backproblems) in molecular biology. Over the last half century, we have gathered increasingly accurate measurements of biological systems and their actors. In this course, we will cover how knowing some of these key numbers can allow us to make useful inferences about biological questions. We will also discuss how quick backlead to better experimental design. This course does not require advanced mathematics and will be good for all biologist.
Insights in Life Sciences Micro-module Proposal Form
Bacterial infection and RNA destiny (BIRD)
Molecular biology by the numbers 3 x 1h lecture
(preferentially, NOT a paper presentation):
/months/semester and times (lunch time or at 6-7 pm):
required (ie. Computer, lab):
Maximum number of students (if applicable):
Minimum number of students you are willing to give the course to:
Open this course to all IBENS personnel: Yes
Outline of lectures (one paragraph):
This course is a short introduction on the use of back-of-the-envelope calculations (Fermi problems) in molecular biology. Over the last half century, we have gathered increasingly
nts of biological systems and their actors. In this course, we will cover how knowing some of these key numbers can allow us to make useful inferences about biological questions. We will also discuss how quick back-of-the-envelope calculations can
better experimental design. This course does not require advanced mathematics and
envelope calculations (Fermi problems) in molecular biology. Over the last half century, we have gathered increasingly
nts of biological systems and their actors. In this course, we will cover how knowing some of these key numbers can allow us to make useful inferences about
envelope calculations can better experimental design. This course does not require advanced mathematics and
MAJ 12/10/18
Micro Name: Nora Assendorp Lab: Triller Lab (biologie de la synapse)Email: [email protected] Micro-module title: The Making of the Human brainMicro-module format: 3 x 1h lecture + exam Exam/evaluation format (preferentially, NOT a paper presentation)choice and open questions Preferred weeks/months/semester2nd semester. Either lunchtime or 6 Additional resources required (ie. Computer Maximum number of students (if applicable): Minimum number of students you are willing to give Open this course to all IBENS personnel: No Language of Instruction: English Outline of lectures (one paragraph): What makes us human? How did earth? Are we special in comparison to other animals? Central to answering these questions stands the evolution of the human brain. During this micro-module I will show you what we have learned about the evolution of our own brain and which aspects still remain to be unraveled. We will discuss the different approaches and touch upon the evolution of language and other closely related topics. By the end of this module you will have insight into our current understanding of human brain evolution and which knowledge gaps still remain to be filled to answer the centuriesquestions above.
Insights in Life Sciences Micro-module Proposal Form
Lab: Triller Lab (biologie de la synapse)
The Making of the Human brain 3 x 1h lecture + exam
(preferentially, NOT a paper presentation): written exam. Multiple
ths/semester and times (lunch time or at 6-7 pm) : semester. Either lunchtime or 6-7pm is fine
Additional resources required (ie. Computer, lab): no
Maximum number of students (if applicable): no
Minimum number of students you are willing to give the course to: 3
Open this course to all IBENS personnel: No
English
Outline of lectures (one paragraph):
What makes us human? How did Homo sapiens end up being the dominant species on th? Are we special in comparison to other animals?
Central to answering these questions stands the evolution of the human brain. During this module I will show you what we have learned about the evolution of our own brain and
ain to be unraveled. We will discuss the different approaches and touch upon the evolution of language and other closely related topics. By the end of this module you will have insight into our current understanding of human brain
ledge gaps still remain to be filled to answer the centuries
written exam. Multiple
end up being the dominant species on
Central to answering these questions stands the evolution of the human brain. During this module I will show you what we have learned about the evolution of our own brain and
ain to be unraveled. We will discuss the different approaches and
By the end of this module you will have insight into our current understanding of human brain ledge gaps still remain to be filled to answer the centuries-old
MAJ 12/10/18
Micro Name: Gianluca TEANO Lab: Chris Bowler Email: [email protected] Micro-module title: DNA folding and but your DNA is not. Micro-module format: 3 x 1h lecture +1h exam Exam/evaluation format : short open questions Preferred weeks/months/semesterlunch time second semester Additional resources required Maximum number of students (if applicable): Minimum number of students you are willing to give the course to: 1 Open this course to all IBENS personnel: No Language of Instruction: english Outline of lectures (one paragraph): Have you ever tried to fold a piece of paper 42 times? Pretty hard eh? Well if you manage to do that, it would be as thick as the distance from the Hearth and the moon. Humans DNA is as long as 2 meters, and it is folded enough time to fit a cell which lenbetter it is confined in the few tenth on how organisms are capable of folding and concentrate DNA into such small volume still being able to access the information in it. Differcondensation will be presented spanning from cytology approach. Mounting evidence indicates that nuclear architecture and the chromatin landscape are linked to the transcriptional state of abegun to converge with spatial, 3Chromosome Conformation Capture (3C)environmentally mediated changes in higherwith genome expression and epigenome reprogramming will be discussed.
Insights in Life Sciences Micro-module Proposal Form
DNA folding and nuclear organization. You might be disorganized
3 x 1h lecture +1h exam
: short open questions
/months/semester and times (lunch time or at 6-7 pm) :
Additional resources required none
Maximum number of students (if applicable):none
Minimum number of students you are willing to give the course to: 1
Open this course to all IBENS personnel: No
english
Outline of lectures (one paragraph):
Have you ever tried to fold a piece of paper 42 times? Pretty hard eh? Well if you manage to do that, it would be as thick as the distance from the Hearth and the moon. Humans DNA is as long as 2 meters, and it is folded enough time to fit a cell which length span few better it is confined in the few tenth µm3 volume of the nucleus. This microon how organisms are capable of folding and concentrate DNA into such small volume still being able to access the information in it. Different technical approach to study DNA
be presented spanning from cytology to the modern genome wide 3 D ounting evidence indicates that nuclear architecture and the chromatin
landscape are linked to the transcriptional state of a given cell. DNA linear information has begun to converge with spatial, 3-dimensional (3D) information obtained by cytogenetic and Chromosome Conformation Capture (3C)-based methodologies. Few environmentally mediated changes in higher-order nuclear organization and their relationship with genome expression and epigenome reprogramming will be discussed.
nuclear organization. You might be disorganized
Have you ever tried to fold a piece of paper 42 times? Pretty hard eh? Well if you manage to do that, it would be as thick as the distance from the Hearth and the moon. Humans DNA is
gth span few µm, even volume of the nucleus. This micro-module will focus
on how organisms are capable of folding and concentrate DNA into such small volume still ent technical approach to study DNA
to the modern genome wide 3 D ounting evidence indicates that nuclear architecture and the chromatin
given cell. DNA linear information has dimensional (3D) information obtained by cytogenetic and
Few example of lear organization and their relationship
with genome expression and epigenome reprogramming will be discussed.
MAJ 12/10/18
Micro Name: Aurélie Gourgeon Lab: Clément LENA / Daniela PopaEmail: [email protected] Micro-module title: The HoudiniMicro-module format: 3 x 1h lecture or Exam/evaluation format (preferentially, NOT a paper presentation): exam Preferred weeks/months/semester and times (lunch time or at 6Will see, second semester Additional resources required (ie. Computer, lab): Maximum number of students (if applicable): none Minimum number of students you are willing to give the course to: none Open this course to all IBENS personnel: Language of Instruction: French or english Outline of lectures (one paragraph): To understand and interact with our environment, the brain collects sensory information but more importantly interprets them to create its own representation. This interpretation reflects usually the close reality but mechanism underlying mismatches between reality and brainvestibular, proprioceptive and memory systems.
Insights in Life Sciences Micro-module Proposal Form
ment LENA / Daniela Popa
Email: [email protected]
The Houdini’s brain or The brain, this unknown illusionist3 x 1h lecture or 3 x 1h lecture + 1h exam
Exam/evaluation format (preferentially, NOT a paper presentation): exam
Preferred weeks/months/semester and times (lunch time or at 6-7 pm) :
Additional resources required (ie. Computer, lab): none
Maximum number of students (if applicable): none
Minimum number of students you are willing to give the course to: none
Open this course to all IBENS personnel: Yes or No
French or english
Outline of lectures (one paragraph):
To understand and interact with our environment, the brain collects sensory information but more importantly interprets them to create its own representation. This interpretation reflects
in some cases the brain builds illusions. I will present some mechanism underlying mismatches between reality and brain’s perception in the visual, vestibular, proprioceptive and memory systems.
this unknown illusionist
To understand and interact with our environment, the brain collects sensory information but more importantly interprets them to create its own representation. This interpretation reflects
in some cases the brain builds illusions. I will present some s perception in the visual,
MAJ 12/10/18
