L'EQUIPE M3V MODELISATION MULTI-ECHELLES DE LA MATIERE VIVANTE

du Laboratoire de Physique Théorique de la Matière Condensée (LPTMC)vous invite au

COLLOQUE

Architecture nucléaire et dynamique fonctionnelle des chromosomes

UPMC, Paris, 10-11 juin 2010Amphi Astier

PROGRAMME

Jeudi 10 juin13h30 Accueil13h50 Introduction14h - 15h35. Session 1: Positionnement des nucléosomes etc... (aspects physiques et biologiques)Milani/ Chevereau Approche expérimentale et théorique du positionnement nucléosomalOlivier Cuvier Genome-wide Insulator-encoded Nucleosome-PositioningKerstin Bystricky Live cell microscopy approaches to dissect chromatin dynamics in 3D at high temporal resolution15h40 - 17h15. Session 2: Réplication (aspects physiques et biologiques)Claude Thermes Spatio-temporal organisation of replicationPart I Benjamin Audit Spatio-temporal organisation of replication Part II Arach Goldar Measuring the time dependent rate of replication origin activation in a single Saccharomyces cerevisiae cellMarcel Méchali DNA replication: from origin recognition to cell identity1715 - 17h45. Pause.17h45 - 19h20. Session 3: organisation spatiale, procaryotes, diffusionAngela Taddei Clustering heterocromatin: Sir3 promotes telomere clustering independently of silencing in budding yeastOlivier Espéli Analysis of the spatial organization of the bacterial chromosomeIvan Junier Spatial and topological organization of DNA chains induced by gene co-localizationOlivier Bénichou First-passage times of diffusion processes and Geometry-controlled kinetics

Vendredi 11 juin9h Accueil9h30 - 10h45. Session 4: biologie des systèmes, réparation, "foci" (aspects physiques et (radio)biologiques)Arndt Benecke Christophe Escudé Repeated DNA sequences and nuclear architecture : new approachesNicolas Foray Individual susceptibility to radiosensitivity and to genomic instabilityOlivier Piétrement10h45 - 11h15. Pause11h15 - 12h30. session 5: Approches multi-échelles de l'architecture nucléaireAnnick Lesne Functional architecture and dynamics of the chromatin fiber: a systemic viewpointRalf Everaers A local and a global view on chromosmal structure: the nucleosomal stem versus chromosome territoriesThierry Forné Dynamics and supranucleosomal organization of the mammalian chromatinAlexander Grosberg Crumpled globule model of chromosomes

organisation : Jean-Marc VictorChristophe LavelleJulien MozziconacciMaria Barbi