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Salle de conférence E2-03, Hôpital du Saint-Sacrement
Visioconférence : CHUL, salle J-0157 / HEJ, LOEX, salle R-138
« Investigating the use of inhibitors of MNK1/2 in invasive and
metastatic cancer »
Pre Sonia del Rincón, Ph.D. Professeur adjointe McGill University Invitée par : Pre Solange Landreville
Lundi 25 novembre 2019
IRIS # 2229242
15h00
Résumé de la conférence.
The eIF4F complex, a critical regulator of mRNA translation can be viewed as a molecular bridge between upstream oncogenic signaling and downstream protein synthesis. Although inhibitors of eIF4F complex members exist (against eIF4A, eIF4G and eIF4E), our approach to block metastatic disease is to block the activity of MNK1/2, the kinases which phosphorylate eIF4E. We have shown that MNK1/2 inhibitors hold therapeutic promise in breast cancer and melanoma. Our research is focused on understanding the tumor-intrinsic and –extrinsic (in immune cells) effects of MNK1/2 signaling.
