/ Annales françaises d’oto-rhino-laryngologie et de pathologie cervico-faciale 131 (2014) A29–A68 A47

les classifications étaient corrélées à plusieurs indices acoustiquesdéterminés dans les stimuli (indices relatifs à la fréquence fonda-mentale F0, indices temporels, indices spectraux) par mesure ducoefficient r de Pearson.Résultats La distance inter objet moyenne était significativementplus élevées dans le groupe des implantés cochléaires (13,1, IC95 % :12,2–13,9) que dans le groupe des sujets normo-entendants(9,6, IC 95 % :8,1–11,2), ce qui traduit un déficit de catégorisationauditive chez les sujets implantés. Ce déficit était plus marquédans les catégories « voix » (distance moyenne de 11,2 chez lesimplantés contre 6,9 chez les normo-entendants) et « musique »(distance moyenne de 13,9 chez les implantés contre 5,5 chezles normo-entendants). Malgré ce déficit, l’analyse MDS retrouvaitdes catégories voix et musique reproductibles chez les implantés.Nos analyses préliminaires montrent que les dimensions utiliséespour réaliser ces classifications étaient corrélées à la saillance dela fréquence fondamentale ainsi qu’à l’impulsivité dans les stimuliauditifs.Conclusion La catégorisation libre de sons naturels est un outiloriginal permettant d’évaluer les performances auditives globalesdes patients implantés cochléaires. La mise en évidence des indicesacoustiques préférentiellement utilisés peut avoir un impact sur lesaméliorations à apporter aux stratégies de codage du son.

Déclaration d’intérêts Les auteurs n’ont pas transmis de déclara-tion de conflits d’intérêts.

http://dx.doi.org/10.1016/j.aforl.2014.07.125

Chirurgie cervico-faciale et cancerologieDimanche 12 octobre 2014 14:30–16:00Salle 252 BSous l’égide de de la Société francaise de carcinologiecervico-facialePrésidents de séance: B. Barry, O. Laccourreye

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A multicenter and case-control studyof human papillomavirus andlaryngeal cancer in a ChinesepopulationY. Xu 1,∗, W. Jiadong 1, D. Pin 2, Y. Shankai 3

1 Shanghai Renji Hospital, Shanghai, China2 Shanghai First People’s Hospital, Shanghai, China3 Shanghai Sixth People’s Hospital, Shanghai, China∗ Corresponding author.

Substantial molecular evidence suggests a role for human papil-lomavirus (HPV) in the pathogenesis of laryngeal squamous cellcarcinoma (LSCC), but epidemiologic and prognosis data have beeninconsistent in a Chinese population.Matériel et méthodes: This multicenter and case control study inclu-ded 674 LSCC patients and 674 control patients treated in threecenters in Shanghai from 2006 till 2013. We used immunohisto-chemistry (IHC) and GenoArray genotyping assay to evaluate theHPV infection status and determined its prevalence and influenceon disease prognosis.Résultats: The total prevalence of HPV DNA was 4,9 % (33/674) inLSCC patients and 0 % (0/674) in control cases in our series (P < 0,01).HPV positive was more common in nonsmokers (13 % nonsmokersvs. 6 % somkers, P < 0,05), in nondrinkers (11 % nondrinkers vs. 6 %drinkers, P < 0,05) and in supraglottic LSCC (12 % supraglottic, 7 %glottic vs. 0 % subglottic, P < 0,05). In 33 HPV positive patients, 28(84.8 %) were HPV-16, 2 (6.1 %) were HPV-18, and 1 (3.0 %) each

HPV-31, HPV-45 and HPV-33 positive. The 3-year overall survivalrate was 76.3 % for HPV positive patients and 70.7 % for HPV nega-tive patients (P = 0.30). The 3-year disease progression-free rate was65.1 % for HPV positive patients and 58.3 % for HPV negative ones(P = 0.37).Conclusion: A very low prevalence of HPV was among LSCC patientsin a Chinese population. HPV was more common in nonsmokers,non-drinkers and supraglottic LSCC patients. The presence of HPVDNA was not associated with patients’ overall survival and diseaseprogression-free rate in our series.

Disclosure of interest The authors have not supplied their decla-ration of conflict of interest.

http://dx.doi.org/10.1016/j.aforl.2014.07.126

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Observation à long terme despatients traités par crico-hyoido-épiglottopexiesM. FeiFaculte de médecine, université Jiao Tong, Shanghai, China

Objective To investigate the long-term results of cricohyoidoepi-glottopexy(CHEP) in the treatment of glottic carcinoma.Methods A retrospective chart review of 92 consecutive patientswho underwent CHEP in the selected institut from January 1990to December 2008. Of the 92 cases, 41 cases of stage I, 39 cases ofstage II, 12 cases of stage III. The time for the decannulation and theremoval of the nasal feeding and quality of phonation were usedfor evaluating postoperative functional rehabilitation. The esti-mated long-term survival rates were calculated by Kaplan–Meiermethod.Results Among 92 patients, 26 cases(27 sides) received elec-tive neck dissection and lymph nodes were pathologically positivein 3 patients(11.1 %). All final surgical margins were negative fortumor invasion. Seven patients had postoperative radiotherapy andone had chemoradiation. Thirteen patients (14.3 %) were foundlocal recurrence and nine patients(9.7 %) had postoperative metas-tases. Overall 3-, 5-and 10-year survival rates were 90.01 %, 84.48 %and 66.93 % respectively. Cox multivariate analysis showed thatthe recurrence had significant influences on the overall survivalrate.Conclusion CHEP not only is relatively easy to master, but alsoeffective in the treatment of glottic carcinoma.

Déclaration d’intérêts Les auteurs n’ont pas transmis de déclara-tion de conflits d’intérêts.

http://dx.doi.org/10.1016/j.aforl.2014.07.127

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Phase 2 clinical feasibility study of anew Speaking Valve with a heat- andmoisture exchanger (DualCare) fortracheotomized patientsB. De kleijn ∗, J. Wedman , B. Van der laanUniversity Medical Center Groningen (UMCG), Groningen,Netherlands∗ Auteur correspondant.

But de la présentation Tracheotomized patients lack the functionof the upper airway moisturizing, warming and filtering air. Fur-thermore they are unable to speak without occluding the cannula.Heat and Moisture Exchangers (HME) and hands-free speakingvalves are developed to aid patients. The Protrach DualCare (AtosMedical, Hörby, Sweden) is the first device combining a fully func-tional HME and hands-free speaking valve for tracheotomizedpatients. This study is performed to determine the clinical feasi-bility of the Dualcare.