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Séminaire des nouveaux arrivants – UMR8601
Amit Kumar
Laboratoire de Chimie et Biochimie Pharmacologiques et
Toxicologiques
Faculté des Sciences Fondamentales et Biomédicales
Université Paris Descartes
07/2009 – 06/2011 Master of science
Industrial chemistry (Pharmaceutical chemistry)
Guru nanak khalsa college Yamunanagar
(Kurukshetra University, Kurukshetra)
Haryana, INDIA
07/2005 – 05/2009 Bachelor of science
Guru nanak khalsa college Yamunanagar
(Kurukshetra University, Kurukshetra)
Haryana, INDIA
08/2011 – 11/ 2011 Master Thesis
R&D on constituent of chemotherapeutic agents
Teva API india Ltd. Greater Noida U.P. INDIA
Curriculum vitae
1
Industrial Experience
Research Trainee
Teva API India Ltd.
2G, 2H, 2I, Ecotech – II
UdyogVihar, Greater Noida, UP – 201 306
12/2011 -31/2012
Acquired skills:
Impurity synthesis and isolation of APIs and starting materials
01/2013 -06/2014 Research Associate
Teva API India Ltd.
2G, 2H, 2I, Ecotech – II
UdyogVihar, Greater Noida, UP – 201 306
Acquired skills:
Impurity synthesis and isolation of APIs and starting materials
including preparation of reference standard & trouble shooting of APIs 2
JOB WORK:
Synthesized and isolation impurities of different APIs, starting
materials, and intermediates: Anti hypertensives, Diuretics,
Opthalmic & psycho-actives, Antibiotics, Dyslipidemia drugs etc;
R&D & trouble shooting of process and preparation of reference
standards;
Technology transfer up to piloting.
06/2014 -03/2015
Research Scientist ( Executive)
Micro labs Api ltd.
Division 43-45 Kiadb Jigni Bomansandra link road
industrial area phase ii Banglore,INDIA
Responsibilites: Management & teamwork
Research and development of APIs, trouble shooting, impurity
synthesis and isolation of APIs
3
1. Isolation and synthesis of known and unknown
impurities of different APIs and intermediates
For example:
4
i)
ii)
5
iii)
iv) More examples:
6
For example:
2. R&D & trouble shooting of
process & technology transfer
Thesis project
Development of remotely controllable polymersomes for
image guided drug delivery deep within the body
Directeurs de thèse : Pr. Hamid Dhimane & Dr. Peter I. Dalko
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques
Faculté des Sciences Fondamentales et Biomédicales
Université Paris Descartes
7
ENSCBP-University of Bordeaux
Laboratoire de Chimie des Polymères
Organiques
Polymersomes
USPCI, UFR Biomédicale de Santé,
Laboratoire de Chimie et Biochimie
Pharmacologiques et Toxicologiques,
Redox probes
S. Lecommandoux
P. I. Dalko
H. Dhimane
Organic Synthesis
Polymer Chemistry
Bioimaging, Biology
B.-T. Doan
D. Scherman 2D and 3D imaging Biodistribution, Tumor models
Laboratoire d'Optique Appliquée
ENSTA-ParisTech,
Ecole Polytechnique
P. Zeitoun
X-Ray
ParisTech, ENSCP,
Unité de Technologies Chimiques et
Biologiques pour la Santé
Broad band and coherent X-ray 8
THE NANOMEDICINE RESEARCH
AGENDA:
Nanodiagnostics: early and accurate
diagnostics
-biosensors and miniaturized devices
-targeted imaging agents to highlight of disease
Targeted Drug Delivery: on the spot
-bring the drug to the target site and monitor its
impact
Regenerative Medicine: stimulated
repair
-help the body to (re)built organs or systems
9
NANOVECTORS AS THERAPEUTICS
Liposomes Antibodies and their conjugates Viral vectors Polymeric micelles
Dendrimers and Dendrons Block copolymers Nanoparticles Polymer-proteins conjugates
Nanovectors
10
11
Development of remotely controllable polymersomes for
image guided drug delivery deep within the body
Petit, M.; Bort, G.; Doan, B.-T.; Sicard, C.; Ogden, D.; Scherman, D.; Ferroud, C.; Dalko, P. I. Angew. Chem. Int. Ed.
2011, 50, 9708 –9711 (cover of the week).
Petit, M. ; Bort, G.; Sicard, C.; Ogden, D.; Dalko, P. I.. IP n°10290323.4, 2010
Can be controlled precisely
in terms of the energy and space
WIREs Nanomed Nanobiotechnol 2012, 4:525–546
H. De Oliveira, J. Thevenot, S. Lecommandoux,
X-ray Tissue /Cell
Stimuli-responsive drug delivery
12
Principle of the Auger electron generation
13
N
N
N N
NH
HN
O
OO
H
17
O
O
OO
44I
Block-copolymer
N
N
N N
NH
HN
O
OO
H
17
O
O
OO
44I
Block-copolymer
N
N
N N
NH
HN
O
OO
H
17
OH
I
gamma-PBLG
O
OO
44
HO
Peg-COOH
Redox fragmentation of the
diblock amphiphile
e _
14
Synthesis of the redox co-polymer
NH
O
O
O
OBn
O
H2N N3 N3 NH
HN
O
OBnO
+ Hn
DMF, 40 oC
18 Hrs
Hydrophilic block:
BrO
O
+60% NaH
THF
OHO
O
43
OO
O
44 O
20% TFA
in DCM
OHO
O
44 Ot-Butyl
Bromoacetate PEG-COOH
Hydrophobic block:
15
NOH
Br
+ NO
Cl O
OO
44
HO
O
OO
44
EDC, DMAP
Dry DCM
gamma
PEG-COOH
gamma-PEG
NO
Cl O
OO
44
gamma-PEG
N3 NH
HN
O
OO
H30
N
N
N N
NH
HN
O
OO
H30
O
O
OO
44I
CuI, DIPEA
dry THF+
Azido-PBLG
PEG-gamma-PBLG
Synthesis of the redox co-polymer
16
17
Polymersomes
1
2
3
45 6
7
8
9
1 10
2
3
45 6
7
8
9
11
Organic
Solvent
Water Controlled
flow rate Organic (10 % v/v
Water (90 % v/v)
Copolymer
+ drug
+ nanoparticles
Micelles
OUTSIDE STORY
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