CLUB HÉMATOPOÏÈSE ET ONCOGENÈSE - · PDF fileCLUB HÉMATOPOÏÈSE ET ONCOGENÈSE Société Française d’Hématologie # ’ Thursday,October13,2016,9:00–11:45am/Session2’

CLUB HÉMATOPOÏÈSE ET ONCOGENÈSE

Société Française d’Hématologie

O. Hérault, President E. Lauret, Secretary E. Delabesse, Assistant Secretary E. Duprez, Treasurer M. Aurrand-‐Lions, Assistant Treasurer

F. Pflumio, Vice-‐president P. Lutz T. Mercher C. Pouponnot I. André-‐Schmutz L. Delva

23rd CHO meeting October 12 – 15, 2016

Giens (Var)

Program Wednesday, October 12, 2016 5:30 – 7:30 pm Registration and welcome cocktail 7:30 pm Diner Wednesday, October 12, 2016 / Session 1 -‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐ 8:30 – 8:45 pm Meeting starter : Olivier Hérault (CHO president) 8:45 – 9:30 pm Emmanuelle Passegué (UCSF, San Francisco, USA) Keynote lecture: "Hematopoietic Stem Cell Function in Stress, Disease and Aging"



Thursday, October 13, 2016, 9:00 – 11:45 am / Session 2 -‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐ Moderators : Michel Aurrand-‐Lions, Béatrice Romagnolo 8:30 – 9:15 am Triantafyllos Chavakis (Univ Carl Gustav Carus, Dresden, Germany) Del1 in the hematopoietic stem cell niche 9:15 – 9:30 am Christelle Freitas (INSERM UMR 996, Clamart, France) Impact of a gain-‐of-‐function mutation of Cxcr4 on hematopoiesis in mice 9:30 – 9:45 am Nicola Sunter (CNRS UMR 7292, Tours, France) Modelling the Leukaemic Niche in 3D: an evaluation of three potential sources of stromal cells 9:45 – 10:00 am Quickfire poster presentations . Session I 10:00 – 10:30 am Break: coffee and cookies 10:30 – 10:45 am Mario Flores Violante (INSERM U1052, CNRS UMR5286, Lyon France) Identification of the role of the BMP pathway in Acute Myeloid Leukemia (AML) through the correlation with ΔNp73 and NANOG, themselves associated with leukemic stem cells 10:45 – 11:00 am Prashanth Kumar Kandalla (CNRS INSERM CIML, Marseille, France) M-‐CSF improves protection against bacterial, fungal and viral infections after hematopoietic stem/progenitor cell transplantation 11:00 – 11:45 am Maria Elena Fernandez-‐Sanchez (Institut Curie, Paris, France) Mechanosensitivity of junctional beta-‐catenin: from mesoderm mechanotransductive evolutionary origins to tumourogenic mechanical induction 12:00 am Lunchbreak



Thursday, October 13, 2016, 15:00 – 15:45 pm / Session 3 -‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐ Moderators : Célio Pouponnot, Pierre Lutz 15:00 – 15:45 pm Béatrice Romagnolo (Institut Cochin, Paris, France) Critical roles for autophagy inhibition in colorectal cancer 15:45 – 16:00 pm Stéphane Manenti (CRCT, Toulouse, France) FLT3-‐ITD receptor induces ATF4-‐dependent autophagy in acute myeloid leukemia 16:00 – 16:15 pm Camille Spinner (UMR 5089, CNRS-‐UPS, IPBS, Toulouse, France) Role of the ASB2α E3 ubiquitin ligase in tumor development 16:15 – 16:30 pm Quickfire poster presentations. Session II 16:30 – 17:00 pm Break : coffee and cookies 17:00 – 17:15 pm Dominique Bluteau (INSERM U944, CNRS UMR 7212, IUH, Paris, France) FANCV (REV7/MAD2L2), a new Fanconi anemia gene 17:15 – 17:30 pm Daniela Barbieri (INSERM U1170, IGR, Villejuif, France) Thrombopoietin restrains retrotransposon-‐mediated DNA damage in hematopoietic stem cells by promoting an anti-‐viral innate immune response 17:30 – 17:45 pm Edwige Voisset (King’s college London, London, UK) Pml nuclear body disruption cooperates in APL pathogenesis, impacting DNA damage repair pathways 17:45 – 18:30 pm Bruno Amati (IIT and IEO, Milan, Italy) Transcriptional programs, genetic modifiers and therapeutic targets in Myc-‐driven tumors 18:30 pm Poster session – Drinks 20:30 pm Diner



Friday, October 14, 2016, 9:00 – 11:45 am / Session 4 -‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐ Moderators : Evelyne Lauret, Olivier Herault 9:00 – 9:45 am Hana Raslova (Institut Gustave Roussy, Villejuif, France) Inherited thrombocytopenias predisposing to hematological malignancies 9:45 – 10:00 am Lise Secardin (INSERM UMR 1170, IGR, Villejuif, France) Modélisation des néoplasmes myéloprolifératifs (NMP) mutés pour la calréticuline par génération de cellules souches induites à la pluripotence (iPSC) 10:00 – 10:15 am Anna Guadall (INSERM U1131, Paris, France) Endothelial cells harbouring JAK2V617F mutation display pro-‐thrombotic characteristics 10:15 – 10:45 am Break: coffee and cookies 10:45 – 11:00 am Lydie Debaize (CNRS UMR 6290, IGDR, Rennes, France) Two hematopoietic transcription factors, RUNX1 and FUBP1, control jointly the expression of c-‐KIT oncogene in pre-‐B lymphoblasts 11:00 – 11:15 am Amelle Vandevelde (CNRS UMR7258, INSERM U1068, CRCM, Marseille, France) Role of PLZF in hematopoietic stem cell stress response 11:15 – 12:00 am Philippe Kastner (IGBMC, Strasbourg, France)

Function of Ikaros family transcription factor in hematopoiesis 12:00 am Lunchbreak 13:30 – 15:30 pm Free time



Friday, October 14, 2016, 15:00 – 19:00 / Session 5 -‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐ Moderators : Thomas Mercher, Laurent Delva 15:30 – 16:15 pm Jurg Schwaller (Dept of Biomedicine University Hospital, Basel, Switzerland) Insights on origin and targets of hematopoietic malignancies by conditional transgenic mouse models 16:15 – 16:30 pm Anne Largeot (CRUM MI, Manchester, UK) Identification of new potential therapeutic targets in MOZ-‐ and MLL-‐ related acute myeloblastic leukaemia 16:30 – 16:45 pm Gaëlle Cordonnier (INSERM U 1151, INEM, Paris, France) CBFβ-‐SMMHC directly regulates ribosomal gene transcription and alters ribosome biogenesis 16:45 – 17:00 pm Break: coffee and cookies 17:00 – 17:15 pm Amélie Guitart (SCRM, Edinburgh, UK) The role of Cited 2 in haematopoiesis regulation 17:15 – 17:30 pm Anne-‐Sophie Alary (INSERM U1016, Institut Cochin, Paris, France) Gene expression and alternative splicing datasets analyses of MDS with ring sideroblasts highlight alternative branchpoint usage in genes involved in iron metabolism and erythropoiesis. 17:30 – 18:15 pm Karima Kissa (UMR5235, Montpellier, France) Origin and fate of haematopoietic stem cells in the zebrafish embryo 18:15 – 19:00 pm CHO General Assembly 20h Diner 21h Reception : « Lets dance and drink (or the reverse) ! »



Saturday, October 15, 2016, 8:30 – 11:30 am / Session 6 -‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐-‐ Moderators : Françoise Pflumio, Isabelle André-‐Schmutz 8:30 – 9:15 am Claudia Waskow (Technische Universität, Dresden, Germany) Mechanism of long-‐term robust human HSC engraftment in mice 9:15 – 9:30 am Bochra Zidi (CNRS UMR 7258, INSERM U1068, CRCM, Marseille, France) Aging-‐associated defects in hematopoietic differentiation involve redox regulation by the stress protein TP53INP1 9:30 – 9:45 am Mathieu Meunier (TIMC-‐Therex, CNRS UMR 5525, Grenoble, France) Mechanisms of improvement of erythropoiesis with low dose deferasirox in low risk myelodysplastic syndromes 9:45 – 10:00 am Break: coffee and cookies 10:00 – 10:15 am Coralie Hoarau-‐Aveila (INSERM U1037, CRCT, Toulouse, France) Methylated miR-‐125b gene is a promising biomarker of resistance to chemotherapy in ALK-‐positive cells with diagnostic potential 10:15 – 11:00 am Michael Rieger (LOEWE Center for Cell and Gene Therapy Frankfurt, Germany) Hematopoietic stem cell self-‐renewal and differentiation control at single cell resolution 11:15 – 11:30 am Award ceremony End of the meeting 12:00 am Lunch and back home journey

Documents

CLUB HÉMATOPOÏÈSE ET ONCOGENÈSE - · PDF fileCLUB HÉMATOPOÏÈSE ET ONCOGENÈSE Société Française d’Hématologie # ’ Thursday,October13,2016,9:00–11:45am/Session2’