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The Function of the DNAM-1 Receptor in Hepatitis C-induced Chronic Liver Inflammation

Jordan Holl

Laboratory of Dr. ShibuyaUniversity of Tsukuba

Known InformationHepatitis CLiver inflammationCirrhosis of the LiverScarringCancer

DNAM-1 (CD226)Elimination of intracellular pathogens via NK/T-cellsVirusesBacteriaTumors

Unknown InformationTo discover the role of DNAM-1 in hepatitis C infection and its resulting inflammation and cirrhosis

MethodologyMultiple mouse knockout strains + controlMonitor observable affects such as disease progression, symptoms, mortality, and immune cell activity.