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BACK
BACK
BACK
β
β
β
β
β
β
β
Δ β
β β
β
β
BACK
on
offmyeloid
(pre)BCR
Notch1
M-CSFR
VH-DJH
BLNK
CD19
Pax5
Ig
lineage-inappropriate genes
B-cell-specific genes
MPOT-lymphoid off
signaling
A BIgH+/+
IgHPax5/Pax5 IgHPax5/Pax5
BACK
β
α
BACK
BACK
BACK
BACK
BACK
α
transcriptional repression
shRNAs ?
X inactivation
Me Ac?
Xist
Me
Me
DNA methylation
Me Me
Me
MeMe
Me
AcHP1Me
Dnmt3b
heterochromatin formation
???
MeMeMe
MeMe Me
PC
PcG silencing
MeMe
Me
MeMe
MeMe MeMeMeMe HP1Me
HP1
MeHP1 MeHP1
Me
Rb
BACK
BACK
α
αα
α
α
αα
α−
A
wildtype
B
C
D
-adaptin
pIIa pIIa
numbwildtype
pIIa pIIb
-adaptin
pIIa pIIa
Notch
pIIb pIIb
-AdaptinNumb
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BACK
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BACK
over-expressionknock-out
brain functions
osteosarcomasosteopetrosis, “op”
activity “op” (arrow)
myosarcomas
Fosconditional
Fos / Fos / Fos brain
Fos-/- p53-/- Fos+
wtwt Fos-/-
wt
brainbone
Fra-1fetus
over-expressionknock-out
conditionalknock-out
Fra-1 replaces Fosviable, but osteopenic
osteosclerosislethality at E9.5
Jun
scoliosislethality at E12.5
cartilageknock-out
liverskin
viable, eye-closuredefect
viable, regenerationdefect
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BACK
*
16
8
20
12
28
24
32
40
36
x 1000 reactions
4
96 97 98 99 00 01 02 03
44
A B C0.005% 6.2% 97%
R1 R1 R1
FITC
PE
FITC
PE
FITC
PE
BACK
/
/
H3-
K9
G9aSuv39h
0
20
40
60
80
unmod. mono di tri
%
0
20
40
60
80
unmod. mono di tri
%
BACK
α
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BACK
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