1
[48] Zhu W, Rawlins BA, Boachie-Adjei O, et al. Combined bone mor- phogenetic protein-2 and -7 gene transfer enhances osteoblastic dif- ferentiation and spine fusion in a rodent model. J Bone Mineral Res 2004;19:2021–32. [49] Cunningham BW, Kotani Y, McNulty PS, Cappuccino A, Kanayama M, Fedder IL, McAfee PC. Video-assisted thoracoscopic surgery versus open thoracotomy for anterior thoracic spinal fusion: a comparative radiographic, biomechanical, and histologic analysis in a sheep model. Spine 1998;23:1333–40. [50] Cook SD, Dalton JE, Tan EH, Whitecloud TS 3rd, Rueger DC. In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions. Spine 1994;19: 1655–63. [51] Magin MN, Delling G. Improved lumbar vertebral interbody fusion us- ing rhOP-1: a comparison of autogenous bone graft, bovine hydroxylap- atite (Bio-Oss), and BMP-7 (rhOP-1) in sheep. Spine 2001;26:469–78. [52] Boden SD, Titus L, Hair G, et al. Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP- 1). Spine 1998;23:2486–92. [53] Boden SD, Martin GJ Jr, Morone MA, Ugbo JL, Moskovitz PA. Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite- tricalcium phosphate after laminectomy in the nonhuman primate. Spine 1999;24:1179–85. [54] Hidaka C, Goshi K, Rawlins B, Boachie-Adjei O, Crystal RG. En- hancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone. Spine 2003;28:2049–57. [55] Wang JC, Kanim LEA, Yoo S, Campbell PA, Berk AJ, Lieberman JR. Effect of regional gene therapy with bone morphogenetic protein-2- producing bone marrow cells on spinal fusion in rats. J Bone Joint Surg 2003;85-A:905–12. [56] Bomback DA, Grauer JN, Lugo R, Troiano N, Patel TC, Friedlaender GE. Spine 2004;29:1612–7. [57] Jhu W, Rawlins BA, Boachie-Adjei O, et al. Combined bone morpho- genetic protein-2 and -7 gene transfer enhances osteoblastic differen- tiation and spine fusion in a rodent model. J Bone Mineral Res 2004;19:2021–32. 45 Years Ago in Spine A method for restructuring images of soft tissues from measurements of discontinuities of ra- diodensity was described by William Henry Oldendorf in 1961 [1]. Improvements led, 14 years later, to Sir Godfrey Hounsfield’s description of computer assisted tomography [2], for which Hounsfield received the 1979 Nobel Prize for Medicine. References [1] Oldendorf WH. Isolated flying spot detection of radiodensity dis- continuities displaying the internal structural pattern of a complex object. IRE Trans Bio-med Electron 1961;8:68–72. [2] Hounsfield GN. Computerized transverse axial scanning (tomogra- phy). Br J Radiol 1975;46:1016–22. 67 R.D. Rao / The Spine Journal 7 (2007) 61–67

0602 system 2 google otenzielle Nutzenbeitrag für das Unterne

Embed Size (px)

DESCRIPTION

Wie gut lässt sich der Nutzen dieses Anwendungsfalls planen? Nutzen Wie groß ist der potenzielle Nutzenbeitrag für das Unternehmen? Anwendungsfall Interne Communities Persönliches Informationsmanagement Projekte und Prozesse 4 Information und offizielle Kommunikation Interne Communities Was macht man damit? − Austauschgruppen – unabhängig von organisatorischen Strukturen − Viele Anwendungsmöglichkeiten wie Ideenmanagement, Frage an die Organisation oder Experten-Communities − Teilnahme basiert vor allem auf intrinsischer Motivation − Engagement in Communities ist meist nicht Teil der Stellenbeschreibung oder Ziel

Citation preview

Page 1: 0602 system 2 google otenzielle Nutzenbeitrag für das Unterne

[48] Zhu W, Rawlins BA, Boachie-Adjei O, et al. Combined bone mor-

phogenetic protein-2 and -7 gene transfer enhances osteoblastic dif-

ferentiation and spine fusion in a rodent model. J Bone Mineral

Res 2004;19:2021–32.

[49] Cunningham BW, Kotani Y, McNulty PS, Cappuccino A,

Kanayama M, Fedder IL, McAfee PC. Video-assisted thoracoscopic

surgery versus open thoracotomy for anterior thoracic spinal fusion:

a comparative radiographic, biomechanical, and histologic analysis in

a sheep model. Spine 1998;23:1333–40.

[50] Cook SD, Dalton JE, Tan EH, Whitecloud TS 3rd, Rueger DC. In

vivo evaluation of recombinant human osteogenic protein (rhOP-1)

implants as a bone graft substitute for spinal fusions. Spine 1994;19:

1655–63.

[51] Magin MN, Delling G. Improved lumbar vertebral interbody fusion us-

ing rhOP-1: a comparison of autogenous bone graft, bovine hydroxylap-

atite (Bio-Oss), and BMP-7 (rhOP-1) in sheep. Spine 2001;26:469–78.

[52] Boden SD, Titus L, Hair G, et al. Lumbar spine fusion by local gene

therapy with a cDNA encoding a novel osteoinductive protein (LMP-

1). Spine 1998;23:2486–92.

[53] Boden SD, Martin GJ Jr, Morone MA, Ugbo JL, Moskovitz PA.

Posterolateral lumbar intertransverse process spine arthrodesis with

recombinant human bone morphogenetic protein 2/hydroxyapatite-

tricalcium phosphate after laminectomy in the nonhuman primate.

Spine 1999;24:1179–85.

[54] Hidaka C, Goshi K, Rawlins B, Boachie-Adjei O, Crystal RG. En-

hancement of spine fusion using combined gene therapy and tissue

engineering BMP-7-expressing bone marrow cells and allograft bone.

Spine 2003;28:2049–57.

[55] Wang JC, Kanim LEA, Yoo S, Campbell PA, Berk AJ, Lieberman JR.

Effect of regional gene therapy with bone morphogenetic protein-2-

producing bone marrow cells on spinal fusion in rats. J Bone Joint

Surg 2003;85-A:905–12.

[56] Bomback DA, Grauer JN, Lugo R, Troiano N, Patel TC,

Friedlaender GE. Spine 2004;29:1612–7.

[57] Jhu W, Rawlins BA, Boachie-Adjei O, et al. Combined bone morpho-

genetic protein-2 and -7 gene transfer enhances osteoblastic differen-

tiation and spine fusion in a rodent model. J Bone Mineral Res

2004;19:2021–32.

67R.D. Rao / The Spine Journal 7 (2007) 61–67

45 YearsAgo in Spine

A method for restructuring images ofsoft tissues from measurements of discontinuities of ra-diodensity was described by William Henry Oldendorf

in 1961 [1]. Improvements led, 14 years later, to SirGodfrey Hounsfield’s description of computer assistedtomography [2], for which Hounsfield received the1979 Nobel Prize for Medicine.

References

[1] Oldendorf WH. Isolated flying spot detection of radiodensity dis-

continuities displaying the internal structural pattern of a complex

object. IRE Trans Bio-med Electron 1961;8:68–72.

[2] Hounsfield GN. Computerized transverse axial scanning (tomogra-

phy). Br J Radiol 1975;46:1016–22.