8/7/2019 Lec 8-Endocrine system

1/30

930(QGRFULQH6\VWHP$Q,QWURGXFWLRQ

8/7/2019 Lec 8-Endocrine system

2/30

2XWOLQH

+RUPRQHV

1HJDWLYHDQG3RVLWLYH)HHGEDFN

(QGRFULQH*ODQGVDQG7KHLU6HFUHWLRQV

8/7/2019 Lec 8-Endocrine system

3/30

,QWURGXFWLRQ

7KHHQGRFULQHV\VWHPFRQVLVWVRIHQGRFULQHJODQGVWKDWVHFUHWHVSHFLILFFKHPLFDOFDOOHGKRUPRQHVLQWREORRGRU

VXUURXQGLQJLQWHUVWLWLDOIOXLG

7KHHQGRFULQHV\VWHPIXQFWLRQVFORVHO\ZLWKWKHQHUYRXVV\VWHPLQUHJXODWLQJDQG

LQWHJUDWLQJERG\SURFHVVHV 0RUHVSHFLILFDOO\KRUPRQHVFDXVHV

FKDQJHVLQWKHPHWDEROLFDFWLYLWLHVLQVSHFLILFFHOOV

8/7/2019 Lec 8-Endocrine system

4/30

,QJHQHUDOWKHDFWLRQRIKRUPRQHVLVUHODWLYHO\VORZDQGWKHHIIHFWVDUHSURORQJHGYVWKHDFWLRQRIQHUYH

LPSXOVHVIDVWDQGWKHVKRUWGXUDWLRQ

8/7/2019 Lec 8-Endocrine system

5/30

+RUPRQHV

DFKHPLFDOPHVVHQJHUVHFUHWHGE\DQHQGRFULQHJODQG

KDVLWVHIIHFWRQVSHFLILFUHFHSWRUVLWHRQWDUJHWFHOOVFDXVLQJDVHULHVRIELRFKHPLFDOHYHQWVWKDWOHDGVWRDVSHFLILFUHVSRQVH

&ODVVLILHGEDVHRQFKHPLFDOVWUXFWXUHDQGWKHORFDWLRQRIWKHFHOOPHPEUDQHUHFHSWRUVRQWKHLUWDUJHWFHOOV

8/7/2019 Lec 8-Endocrine system

6/30

&ODVVLILFDWLRQRIKRUPRQHV

8/7/2019 Lec 8-Endocrine system

7/30

+RUPRQHV

'LYLGHGLQWRWZRJURXSV EDVHGRQWKHORFDWLRQRIWKHUHFHSWRUVRQWKHWDUJHWFHOOV

*URXS,KRUPRQHV

ELQGWRLQWUDFHOOXODUUHFHSWRUVDQGDUHOLSRSKLOLF

LQFOXGHWKHVWHURLGKRUPRQHV

*URXS,,KRUPRQHV ELQGWRFHOOVXUIDFHUHFHSWRUVDQGDUHK\GURSKLOLF

,QFOXGHSRO\SHSWLGHJO\FRSURWHLQDQFFDWHFKRODPLQHKRUPRQHV

8/7/2019 Lec 8-Endocrine system

8/30

1HJDWLYHDQG3RVLWLYH)HHGEDFN

1HJDWLYHIHHGEDFNLQYROYHVDFKDLQRIELRFKHPLFDORUSK\VLRORJLFDOHYHQWV

*HQHUDOO\DQLQFUHDVHGDPRXQWRIHQGSURGXFWLQKLELWVWKHSURGXFWLRQPHFKDQLVPRUDFWLRQRIDVWDUWLQJVXEVWDQFHWRSURKLELWIXUWKHUV\QWKHVLVRIWKHHQGSURGXFW

8/7/2019 Lec 8-Endocrine system

9/30

(J$!%!&!'

$V$SURJUHVVHVWKURXJK%DQG&WR'WKHDPRXQWRI'LQFUHDVHV6XEVWDQFH'

KRZHYHULVLQKLELWRUIRUVXEVWDQFH$$VOHYHORIVXEVWDQFH'LQFUHDVHVXEVWDQFH$UHFHLYHQHJDWLYHIHHGEDFNWRSUHYHQWWKHSURFHVVIURPFRQWLQXLQJWRSURGXFHPRUH'

$QHJLVWKHSURGXFWLRQRIFRUWLVRODQGLWVUHJXODWLRQDORQJWKHK\SRWKDODPLFSLWXLWDU\DGUHQDOD[LV

8/7/2019 Lec 8-Endocrine system

10/30

,QSRVLWLYHIHHGEDFN'LQWKHHJJLYHQZRXOGVWLPXODWH$WRIXUWKHUSURGXFHLQFUHDVHGDPRXQWRI%DQGVRRQWR'

7KLVLVOHVVFRPPRQLQWKHERG\

(JVHFUHWLRQRIR[\WRFLQVWLPXODWLQJFRQWUDFWLRQRIXWHULQHPXVFOHVGXULQJ

ODERU$VODERUSURJUHVVHVSUHVVXUHRQWKHFHUYL[FRQWLQXHVWRVWLPXODWHWKHUHOHDVHRIR[\WRFLQZKLFKFRQWLQXHVWRVWLPXODWHXWHULQHPXVFOHWRFRQWUDFW

8/7/2019 Lec 8-Endocrine system

11/30

+RPHRVWDVLVLVPDLQWDLQHGE\WKHFRQWLQXDODGMXVWPHQWVRIHQGRFULQHIXQFWLRQLQUHVSRQVHWRFKDQJHVLQRXU

HQYLURQPHQW

1HJDWLYHIHHGEDFNLQKLELWVWKHIDFWRUVWKDWSURGXFHGDSURGXFWVRDVWRPDLQWDLQDQRUPDOUDQJHRIYDOXH

3RVLWLYHIHHGEDFNLQFUHDVHVWKHGHYLDWLRQIURPQRUPDOYDOXHVDQGWKXVLVQRWKRPHRVWDWLF

8/7/2019 Lec 8-Endocrine system

12/30

(QGRFULQH*ODQGVDQG7KHLU6HFUHWLRQV

+RUPRQHVDUHV\QWKHVL]HGLQVSHFLDOL]HGJODQGVWLVVXHVDQGFHOOVHJQHXURHQGRFULQHFHOOV

7KHLUWDUJHWRUJDQLVHLWKHUDVXERUGLQDWHHQGRFULQH

JODQGJODQGRWURSLFKRUPRQHRUQRQHQGRFULQHWLVVXHDJODQGRWURSLFKRUPRQH

7KHWDUJHWFHOOVKDYHKLJKDIILQLW\ELQGLQJVLWHVUHFHSWRUVIRUWKHLUVSHFLILFKRUPRQHVRYHU\ORZFRQFHQWUDWLRQVRIWKHKRUPRQHVXIILFHIRUVLJQDO

WUDQVGXFWLRQ WR PRO/

7KHUHFHSWRUVRQWKHWDUJHWFHOOVSLFNRXWWKHVXEVWDQFHVVSHFLILFDOO\LQWHQGHGIRUWKHPIURPDZLGHYDULHW\RIGLIIHUHQWPHVVHQJHUVXEVWDQFHVLQ

WKHLUHQYLURQPHQW

8/7/2019 Lec 8-Endocrine system

13/30

+RUPRQHVZRUNFORVHO\ZLWKWKHQHUYRXVV\VWHPWRUHJXODWHGLJHVWLRQPHWDEROLVPJURZWKPDWXUDWLRQSK\VLFDODQGPHQWDOGHYHORSPHQWPDWXUDWLRQUHSURGXFWLRQDGDSWDWLRQDQGWKHLQWHUQDOPLOLHXRIWKHERG\KRPHRVWDVLV

0RVWRIWKHVHDFWLRQVDUHSUHGRPLQDWHO\DXWRQRPRXVIXQFWLRQVVXEMHFWWRFHQWUDOFRQWUROE\WKHK\SRWKDODPXVZKLFKLVFRQWUROOHGE\KLJKHUFHQWHUVRIWKHEUDLQ

1HXURWUDQVPLWWHUVUHOHDVHGDWFKHPLFDOV\QDSVHVRIQHUYHHQGLQJVWUDQVPLWVLJQDOVWRSRVWV\QDSWLFQHUYHILEHUVPXVFOHVRUJODQGV

8/7/2019 Lec 8-Endocrine system

14/30

6RPHQHXURSHSWLGHVUHOHDVHGE\SUHV\QDSWLFQHXURQVDOVRH[HUWWKHLUHIIHFWVLQQHLJKERULQJV\QDSVHVUHVXOWLQJ

LQDNLQGRISDUDFULQHDFWLRQ 1HXURQVFDQDOVRVHFUHWHKRUPRQHVHJ

HSLQHSKULQHR[\WRFLQDQGDQWLGLXUHWLFKRUPRQH

6RPHWUDQVPLWWHUVXEVWDQFHVRIWKHLPPXQHV\VWHPHJWK\PRVLQDQGYDULRXVF\WRNLQHVDOVRKDYHHQGRFULQH

HIIHFWV

8/7/2019 Lec 8-Endocrine system

15/30

+RUPRQHUHFHSWRUV

7KHUHFHSWRUVGRFNLQJVLWHVIRUJO\FRSURWHLQKRUPRQHVSHSWLGHKRUPRQHVDQGFDWHFKRODPLQHVDUHWUDQVPHPEUDQHSURWHLQVWKDWELQGWRWKHLUVSHFLILFKRUPRQHRQWKHRXWHUFHOOVXUIDFH

0DQ\RIWKHVHKRUPRQHVLQGXFHWKHUHOHDVHRILQWUDFHOOXODUVHFRQGPHVVHQJHUVWKDWWUDQVPLWWKHKRUPRQHVLJQDOLQVLGHWKHFHOOF$03F*03,3'$*&DDQG12IXQFWLRQDVVHFRQGPHVVHQJHUVDQGVRPHWLPHVDVWKLUGPHVVHQJHUV

8/7/2019 Lec 8-Endocrine system

16/30

6RPHSHSWLGHKRUPRQHVOLNHLQVXOLQSURODFWLQDWULRSHSWLQDQGQXPHURXVJURZWKIDFWRUVELQGWRFHOOVXUIDFHUHFHSWRUVZLWKF\WRVROLFGRPDLQVZLWKHQ]\PDWLFDFWLYLW\

6WHURLGKRUPRQHVRQWKHRWKHUKDQGHQWHUWKHFHOOVWKHPVHOYHV2QFHWKH\ELQGWRF\WRVROLFUHFHSWRUSURWHLQVVWHURLGKRUPRQHVDUHWUDQVSRUWHGWRWKHFHOOQXFOHXVZKHUHWKH\

LQIOXHQFHWUDQVFULSWLRQJHQRPLFDFWLRQ $WDUJHWFHOOFDQKDYHGLIIHUHQWUHFHSWRUVIRU

GLIIHUHQWKRUPRQHVHJLQVXOLQDQGJOXFDJRQRUGLIIHUHQWUHFHSWRUVIRUDVLQJOHKRUPRQH

HJUHFHSWRUVIRUHSLQHSKULQH

8/7/2019 Lec 8-Endocrine system

17/30

+LHUDUFK\RIKRUPRQHV

7KHVHFUHWLRQRIKRUPRQHVLVRIWHQWULJJHUHGE\QHXUDOLPSXOVHVIURPWKH&16

7KHK\SRWKDODPXVLVWKHPDLQQHXURKRUPRQDOFRQWUROFHQWHU

+\SRWKDODPLFQHXURQVH[WHQGWRWKH

SRVWHULRUSLWXLWDU\QHXURK\SRSK\VLV 7KHKRUPRQHVDUHVHFUHWHGUHPEHV

HLWKHUVDPDGDE\WKHK\SRWKDODPXVLWVHOIRUE\WKHSRVWHULRUSLWXLWDU\

8/7/2019 Lec 8-Endocrine system

18/30

+\SRWKDODPLFKRUPRQHVDOVRFRQWUROKRUPRQHUHOHDVHIURPWKHDQWHULRUSLWXLWDU\DGHQRK\SRSK\VLV

$QWHULRUSLWXLWDU\JODQGRWURSLFKRUPRQHVFRQWUROSHULSKHUDOHQGRFULQHJODQGVZKLFKUHOHDVHWKHHQGKRUPRQH

7KHRULJLQDOVLJQDOFDQEHDPSOLILHGRUPRGXODWHGPJDWXUDWWKHVHUHOD\WHULPDQEHULVLWHV

8/7/2019 Lec 8-Endocrine system

19/30

(QGRFULQH*ODQGVDQG7KHLU6HFUHWLRQV

(QGRFULQHRUJDQVDUHZLGHO\VFDWWHUHGEHUWDEXUDQWKURXJKRXWWKHERG\ZLWKQRDQDWRPLFDO

FRQWLQXLW\NHODQFDUDQ ,QDGGLWLRQWRWKHGLVFUHWHHQGRFULQH

RUJDQVVHYHUDORWKHURUJDQVUHIHUUHGWRDVPL[HGRUJDQVKDYHDQHQGRFULQHIXQFWLRQWK\PXVVWRPDFKGXRGHQXPSODFHQWDKHDUW

8/7/2019 Lec 8-Endocrine system

20/30

3LWXLWDU\JODQG

/RFDWLRQDQGVWUXFWXUH

RQWKHLQIHULRUVLGHRIWKHEUDLQ

SLWXLWDU\VWDONDWWDFKHVWKHJODQGWRWKHK\SRWKDODPXVSRUWLRQRIWKHEUDLQ

'LYLGHGLQWR

DQWHULRUOREHDGHQRK\SRSK\VLV SRVWHULRUOREHQHXURK\SRSK\VLV

8/7/2019 Lec 8-Endocrine system

21/30

3LWXLWDU\JODQG

6HFUHWLRQDQGHIIHFWV

VHFUHWHGE\DGHQRK\SRSK\VLV

+XPDQJURZWKKRUPRQH+*+ WDUJHWVWKHERQHDQGVRIWWLVVXHV

DFFHOHUDWHVUDWHRIERG\JURZWKE\

VWLPXODWLQJDPLQRDFLGXSWDNHE\FHOOV

LQFUHDVLQJV\QWKHVLVRIW51$

LQFUHDVLQJWKHQXPEHUDQGDJJUHJDWLRQRIULERVRPHV

WKXVSURYLGLQJSURWHLQV\QWKHVLV 7K\URLGVWLPXODWLQJKRUPRQH76+

WDUJHWVWKHWK\URLGJODQG

VWLPXODWHV\QWKHVLVDQGUHOHDVHRIWK\URLGKRUPRQHV

8/7/2019 Lec 8-Endocrine system

22/30

3LWXLWDU\JODQG

6HFUHWLRQDQGHIIHFWV

VHFUHWHGE\DGHQRK\SRSK\VLV

$GUHQRFRUWLFRWURSLFKRUPRQH$&7+ WDUJHWWKHDGUHQDOFRUWH[6WLPXODWHVVHFUHWLRQRI

JOXFRFRUWLFRLGV

3URODFWLQ35/ WDUJHWWKHPDPPDU\JODQGV

SURPRWHVGHYHORSPHQWRIPDPPDU\JODQGVDQGVWLPXODWHVPLONSURGXFWLRQ

UHJXODWHGE\SURGXFWLRQRISODFHQWDOKRUPRQHVGXULQJSUHJQDQF\DQGVWLPXODWLRQRIWKHQLSSOHGXULQJODFWDWLRQ

)ROOLFOHVWLPXODWLQJKRUPRQH)6+ WDUJHWWKHRYDULHVDQGWHVWHV

VWLPXODWHVJURZWKRIRYDULDQIROOLFOHVDQG

VSHUPDWRJHQHVLVLQIHPDOHDQGPDOHVUHVSHFWLYHO\

8/7/2019 Lec 8-Endocrine system

23/30

3LWXLWDU\JODQG

6HFUHWLRQDQGHIIHFWV

VHFUHWHGE\DGHQRK\SRSK\VLV

/XWHLQL]LQJKRUPRQH/+ WDUJHWWKHRYDULHVDQGWHVWHV

IHPDOHVWLPXODWHPDWXUDWLRQRIIROOLFOHVSURPRWHVRYXODWLRQDQGVWLPXODWHFRUSXVOXWHXPWRVHFUHWHHVWURJHQVDQGSURJHVWURQH

PDOHVWLPXODWHLQWHUVWLWLDOFHOOVWRVHFUHWHWHVWRWHURQH

8/7/2019 Lec 8-Endocrine system

24/30

6HFUHWLRQDQGHIIHFWV

VHFUHWHGE\QHXURK\SRSK\VLV

$QWLGLXUHWLFKRUPRQH$'+ WDUJHWWKHNLGQH\WXEXOHV

IDFLOLWDWHZDWHUUHDEVRUSWLRQLQWKHGLVWDOFRQYXODWHGWXEXOHVDQGFROOHFWLQJGXFWV5HOHDVHVWLPXODWHGE\GHK\GUDWLRQDQGLQFUHDVHGSODVPDRVPRODULW\

FRQWUROOHGE\QHJDWLYHIHHGEDFN

2[\WRFLQ WDUJHWVWKHXWHUXVDQGPDPPDU\JODQGV

VWLPXODWHFRQWUDFWLRQRIXWHULQHPXVFOHVDQGVHFUHWLRQRIPLON

UHOHDVHVWLPXODWHGE\VWUHWFKLQJRIXWHUXVODWHLQ

SUHJQDQF\DQGE\PHFKDQLFDOVWLPXODWLRQRIWKHQLSSOHGXULQJQXUVLQJ&RQWUROOHGE\SRVLWLYHIHHGEDFN

8/7/2019 Lec 8-Endocrine system

25/30

8/7/2019 Lec 8-Endocrine system

26/30

8/7/2019 Lec 8-Endocrine system

27/30

8/7/2019 Lec 8-Endocrine system

28/30

$GUHQDOJODQG

8/7/2019 Lec 8-Endocrine system

29/30

8/7/2019 Lec 8-Endocrine system

30/30