PLANTES A ALCALOIDES ET PRODUITS …mastervrv.free.fr/S2/RMA2/Cours/4.pdf · PLANTES A ALCALOIDES ET PRODUITS APPARENTES Bernard Weniger Pharmacognosie et Molécules Naturelles Bioactives

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PLANTES A ALCALOIDES ET PRODUITS APPARENTES

Bernard WenigerPharmacognosie et Molécules Naturelles Bioactives

UMR 7200, Lab. d’Innovation ThérapeutiqueFaculté de Pharmacie - Université de Strasbourg

PLAN DU COURSPLAN DU COURS1.1. Généralités sur les alcaloïdesGénéralités sur les alcaloïdes

!"#$%$&$'%!"#$%$&$'%!$(&)$*+&$'%,!$(&)$*+&$'%,-- "&.&,%.&+)/0"&.&,%.&+)/01$'(2%&34(/,/&,&25/(,(&)+6&+).+71$'(2%&34(/,/&,&25/(,(&)+6&+).+78.).6&")$(&$9+/( 532($6'8.).6&")$(&$9+/( 532($6'--63$:$9+/(63$:$9+/(8.).6&")$(&$9+/(,532($6'8.).6&")$(&$9+/(,532($6' 63$:$9+/(63$:$9+/(;7&).6&$'%;7&).6&$'%

2.2. Monographies de plantesMonographies de plantes<.&$4)/(,5)/:$4)/(,=,6.#"$%/<.&$4)/(,5)/:$4)/(,=,6.#"$%/>.?'&@,'5$+:,/&,:')53$%/>.?'&@,'5$+:,/&,:')53$%/A+$%9+$%.,/&,9+$%$%/A+$%9+$%.,/&,9+$%$%/B'0.%.6"/(,=,.06.0'CD/(,&)'5.%$9+/(B'0.%.6"/(,=,.06.0'CD/(,&)'5.%$9+/(E06.0'CD/(,.%&$&+:').+7,%.&+)/0(E06.0'CD/(,.%&$&+:').+7,%.&+)/0(

GÉNÉRALITÉS

<"&.*'0$(:/,5)$:.$)/:"&.*'0$(:/,#'%D.:/%&.0,F,:'0"6+0/(,$%D$(5/%(.*0/(,=,0.,?$/,D/,0.,50.%&/.6$D/(,.:$%"(@,6/00+0'(/@,.:$D'%@,630')'53200/@,/&6,GG

<"&.*'0$(:/,(/6'%D.$)/:'0"6+0/(,0'%H&/:5(,6'%($D")"/(,6'::/,I%'%,$%D$(5/%(.*0/(I,=,0.,?$/,D/,0.,50.%&/:"&.*'0$(:/,DJ.D.5&.&$'%,D/,0.,50.%&/,.?/6,0/,:$0$/+,KD"#/%(/@,5)'&/6&$'%LM:'0"6+0/(,6.).6&")$(&$9+/(,D+,:'%D/,?"H"&.05)4(,D/,NO,OOO,(&)+6&+)/(,%.&+)/00/(,6'%%+/(,

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Relations biogénétiques entre les différents types de métabolites secondaires

GÉNÉRALITÉS - DÉFINITION

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

[:5')&.%6/,[:5')&.%6/,D/(,.06.0'CD/(,D/(,.06.0'CD/(, %':*)/,K50+($/+)(,:$00$/)(M%':*)/,K50+($/+)(,:$00$/)(M!$?/)($&",(&)+6&+).0/@,H)'+5/,63$:$9+/:/%&,3"&")'H4%/,!$?/)($&",(&)+6&+).0/@,H)'+5/,63$:$9+/:/%&,3"&")'H4%/,/&,0.)H/,"?/%&.$0,D_.6&$?$&"(,*$'0'H$9+/(,/&,0.)H/,"?/%&.$0,D_.6&$?$&"(,*$'0'H$9+/(,]/):/,`]/):/,` .06.0'CD/(.06.0'CD/( a,$%&)'D+$&,5.),</$(%/),.+,\ba,$%&)'D+$&,5.),</$(%/),.+,\b4:/,4:/,

($460/,($460/, (+*&.%6/,)".H$((.%&,6'::/,0.,('+D/,(+*&.%6/,)".H$((.%&,6'::/,0.,('+D/, .0,c.02,.0,c.02,K D MK D M K &MK &M


K('+D/M,d,K('+D/M,d, K.(5/6&MK.(5/6&M>.(,D/,D"#$%$&$'%,($:50/,:.$(,>.(,D/,D"#$%$&$'%,($:50/,:.$(,/7$(&/%6/,D_+%,6'%(/%(+(,/7$(&/%6/,D_+%,6'%(/%(+(,(+),0.,D"#$%$&$'%,D/,6/,9+_/(&,+%,.06.0'CD/,?).$,(+),0.,D"#$%$&$'%,D/,6/,9+_/(&,+%,.06.0'CD/,?).$,FF

` 8':5'("(,DJ')$H$%/,%.&+)/00/@,0/,50+(,('+?/%&,?"H"&.0/@,.e'&"(@,0/,50+(,('+?/%&,*.($9+/(@,/&,D'+"(,=,#.$*0/,D'(/,D/,

5)'5)$"&"(,532($'0'H$9+/(,:.)9+"/( a,

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Les alcaloïdes stéroïdiques dérivent du mévalonate mais sont minoritaire.

Thomas DI PASCOLI

La France est bien placée car importation américaine de pavot français et des alcaloïde de cette plante.

Thomas DI PASCOLI

On ne peut pas faire de sels avec des xanthines et ne sont pas basiques. La caféine est le meilleur lipolytique --> anti-cellulite.

Thomas DI PASCOLI

Alcaloïdes ne sont que des substances naturelles, les substances dérivés ne sont pas des alcaloïdes.

>)'&'>)'&'--.06.0'CD/(,'+,5(/+D'.06.0'CD/(,'+,5(/+D'--.06.0'CD/(,F,.06.0'CD/(,F,

.0c20.:$%/(,/&,.)20.:$%/(,.0c20.:$%/(,/&,.)20.:$%/(,D/,0.)H/,D$(&)$*+&$'%D/,0.)H/,D$(&)$*+&$'%

*"&.0.C%/(*"&.0.C%/(


*"&.0.C%/(*"&.0.C%/(

5/5&$D/(,/&,.6G,.:$%"(5/5&$D/(,/&,.6G,.:$%"(

.:$D/(.:$D/(

5')532)$%/(,GG5')532)$%/(,GG

PSEUDOALCALOÏDE : PSEUDOALCALOÏDE : CAPSAÏCINE CAPSAÏCINE

8.5(.C6$%/,/&,D")$?"(F,.((/e,('0+*0/(,D.%(,/.+,/&,3+$0/

E%.0H"($9+/(,&'5$9+/(@,D"(/%($*$0$(.%&,)"6/5&/+)(,D'+0/+)(@ )+*"#$.%&(@D'+0/+)(@,)+*"#$.%&(@,D$.53')"&$9+/(

f)$H$%/,*$'(2%&3"&$9+/,:$7&/,F,53"%205)'5.%/,d,*).%63/:/%&,63.g%/,.0253.&$9+/

>$H:/%&(,.e'&"(,)/&)'+?"(,D.%(,6/)&.$%/(,>$H:/%&(,.e'&"(,)/&)'+?"(,D.%(,6/)&.$%/(,#.:$00/(,*'&.%$9+/(,K)/:50.6/%&,.%&3'62.%/(M#.:$00/(,*'&.%$9+/(,K)/:50.6/%&,.%&3'62.%/(M>)'5)$"&"(,.%&$'7$D.%&/(>)'5)$"&"(,.%&$'7$D.%&/(

PSEUDOALCALOÏDE : PSEUDOALCALOÏDE : BÉTALAÏNES BÉTALAÏNES

0123456547

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI


E06.0'CD/(,%/,6'%&/%.%&,5.(,D_'72H4%/,FE06.0'CD/(,%/,6'%&/%.%&,5.(,D_'72H4%/,F0$9+$D/(,=,&/:5").&+)/,')D$%.$)/0$9+$D/(,=,&/:5").&+)/,')D$%.$)/

?'0.&$0(@,/%&).g%.*0/(,=,0.,?.5/+),D_/.+,?'0.&$0(@,/%&).g%.*0/(,=,0.,?.5/+),D_/.+,

%$6'&$%/ (5.)&"$%/

SX,SX, 1.6&")$/(,K1.6&")$/(,KPseudomonasPseudomonasMM

83.:5$H%'%(,K5($0'62*/@,.:.%$&/@,/)H'&M83.:5$H%'%(,K5($0'62*/@,.:.%$&/@,/)H'&M

ALCALOÏDESALCALOÏDESDistribution Distribution -- état naturel état naturel

Y2:%'(5/):/(,KY2:%'(5/):/(,KTaxus, EphedraTaxus, EphedraM,M,

Rh,X,D/(,.06.0'CD/(,(/,)/&)'+?/%&,63/e,0/(,,Rh,X,D/(,.06.0'CD/(,(/,)/&)'+?/%&,63/e,0/(,,!$6'&20"D'%/(,,!$6'&20"D'%/(,,U%/,9+$%e.$%/,D/,#.:$00/(,('%&,5.)&$6+0$4)/:/%&U%/,9+$%e.$%/,D/,#.:$00/(,('%&,5.)&$6+0$4)/:/%&)$63/(,/%,50.%&/(,=,.06.0'CD/()$63/(,/%,50.%&/(,=,.06.0'CD/(


i/(,50+(,$:5')&.%&/(,('%&,0/(,(+$?.%&/(,Fi/(,50+(,$:5')&.%&/(,('%&,0/(,(+$?.%&/(,FE%%'%.6"/(@,E5'62%.6"/(@,i.+).6"/(@,E%%'%.6"/(@,E5'62%.6"/(@,i.+).6"/(@,i'H.%$.6"/(@,<"%$(5/):.6"/(@,i'H.%$.6"/(@,<"%$(5/):.6"/(@,>.5.?/).6"/(@,j+*$.6"/(@,B'0.%.6"/(L>.5.?/).6"/(@,j+*$.6"/(@,B'0.%.6"/(L

Y0'*.0/:/%&,F,\OY0'*.0/:/%&,F,\O--\W,X,D/(,E%H$'(5/):/(,,,\W,X,D/(,E%H$'(5/):/(,,,6'%&$/%%/%&,D/(,6'%&$/%%/%&,D/(,.06.0'CD/(,/%,9+.%&$&",%'&.*0/(.06.0'CD/(,/%,9+.%&$&",%'&.*0/(

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Psilocibine est un analogue de la sérotonine et c'est un des rare alcaloïde phosphoré du monde naturel. Psilocine = psilocibine dephosphorylée dans l'organisme.

Thomas DI PASCOLI

Gymnosperme et les monocotylédones.Ephedra première plante d'ou on a extrait l'ephédrine. Tous les alcaloïdes présentes ici appartiennent à des plantes de la famille des Liliacées. La colchicine ressemble à la caféine car l'azote est extra cyclique (amide) et qui est soluble dans un peu tous les solvant comme la caféine. On a un noyau tropolone (7C).La lycorine est un alcaloïde de type pseudo-morphine et c'est dans ces espèces qu'on trouve la galanthamine (traitement Alzheimer). L'hellébore blanc = vératre.

Thomas DI PASCOLI

Beaucoup de plantes contiennent des quantités à l'état de trace d'alcaloïdes, il faut plus de 0,1% pour que la quantité soit notable.


k.*$&+/00/:/%&,=,0l"&.&,D/,(/0(,D.%(,0.,50.%&/F,:.0.&/@k.*$&+/00/:/%&,=,0l"&.&,D/,(/0(,D.%(,0.,50.%&/F,:.0.&/@6$&).&/@,&.)&).&/,.$%($,9+_,/%,6':*$%.$('%,.?/6,0/(,&.%$%(6$&).&/@,&.)&).&/,.$%($,9+_,/%,6':*$%.$('%,.?/6,0/(,&.%$%(i'6.0$(.&$'%,i'6.0$(.&$'%, &$((+(,5")$53")$9+/(&$((+(,5")$53")$9+/(j"5.)&$&$'%,D$?/)($#$"/,Fj"5.)&$&$'%,D$?/)($#$"/,F

0.)H/,F,6.#"$%/@,)"&$6+0$%/0.)H/,F,6.#"$%/@,)"&$6+0$%/)/(&)/$%&/,F,32'(6$.:$%/,KB'0.%.6"/(M@,:')53$%/,K)/(&)/$%&/,F,32'(6$.:$%/,KB'0.%.6"/(M@,:')53$%/,KPapaverPapaverM,M,('+?/%&,:"0.%H/,6':50/7/,D_')$H$%/,*$'(2%&3"&$9+/,6'::+%/,('+?/%&,:"0.%H/,6':50/7/,D_')$H$%/,*$'(2%&3"&$9+/,6'::+%/,

]/%/+),F,]/%/+),F,?.)$/,D.%(,D/,0.)H/(,0$:$&/(,F,"&.&,D/,&).6/(,?.)$/,D.%(,D/,0.)H/(,0$:$&/(,F,"&.&,D/,&).6/(, \N,\N,X,K9+$%9+$%.MX,K9+$%9+$%.M?.)$.*$0$&",$:5')&.%&/,K/%?$)'%%/:/%&@,(.$('%@,3/+)/M?.)$.*$0$&",$:5')&.%&/,K/%?$)'%%/:/%&@,(.$('%@,3/+)/M

V'%6&$'%(,D.%(,0.,50.%&/,0.)H/:/%&,:"6'%%+/(,F,V'%6&$'%(,D.%(,0.,50.%&/,0.)H/:/%&,:"6'%%+/(,F,5)'D+$&(,D_/76)"&$'%,D+,:"&.*'0$(:/,.e'&"5)'D+$&(,D_/76)"&$'%,D+,:"&.*'0$(:/,.e'&")"(/)?/,D_.e'&/@,D"#/%(/,6'%&)/,0/(,5)"D.&/+)(,LG)"(/)?/,D_.e'&/@,D"#/%(/,6'%&)/,0/(,5)"D.&/+)(,LG

BIOSYNTHÈSE ET TYPES STRUCTURAUXBIOSYNTHÈSE ET TYPES STRUCTURAUX

BIOSYNTHÈSE ET TYPES STRUCTURAUXBIOSYNTHÈSE ET TYPES STRUCTURAUX

Thomas DI PASCOLI

Thomas DI PASCOLI

Thomas DI PASCOLI

Les tanins ont une affinité pour les molécules contenant des azotes, aussi pour cela qu'on peut tanner les peaux.

CARACTÉRISTIQUES PHYSICOCARACTÉRISTIQUES PHYSICO--CHIMIQUES CHIMIQUES

N

5k,.06.0$%,F,5k,.06.0$%,F,

9+$%'0"$%/,9+$%'0"$%/,*.(/,*.(/, ('0+*0/,,,('0+*0/,,,D.%( ('0?.%&( ')H.%$9+/(D.%( ('0?.%&( ')H.%$9+/( /&/&

B'0+*$0$&",D/(,.06.0'CD/(,(/0'%,0/,5k,FB'0+*$0$&",D/(,.06.0'CD/(,(/0'%,0/,5k,F

N

NH

+CH3COO

D.%(,('0?.%&(,')H.%$9+/(,D.%(,('0?.%&(,')H.%$9+/(,/&,/&,0/(,0/(,.06''0(.06''0(

5k,.6$D/,K/7F,.6G,.6"&$9+/M,F

.6"&.&/,D/,9+$%'0"$%/, ('0+*0/D.%(,0_/.+,/&,0/(,.06''0(

CARACTÉRISTIQUES PHYSICOCARACTÉRISTIQUES PHYSICO--CHIMIQUESCHIMIQUES

E+&)/,/7/:50/E+&)/,/7/:50/F,6'6.C%/,*.(/,/&,630')32D).&/,D/,6'6.C%/,F,6'6.C%/,*.(/,/&,630')32D).&/,D/,6'6.C%/,

CARACTÉRISTIQUES PHYSICOCARACTÉRISTIQUES PHYSICO--CHIMIQUESCHIMIQUES

B'0+*$0$&",D/(,(/0(,D.%(,0J/.+,FB'0+*$0$&",D/(,(/0(,D.%(,0J/.+,F630'32D).&/(,m,(+0#.&/(,m,&.)&).&/(630'32D).&/(,m,(+0#.&/(,m,&.)&).&/(

B'0+*$0$&",D.%(,0_.06''0,F,B'0+*$0$&",D.%(,0_.06''0,F,*.(/( /& (/0( ('%& ('0+*0/( D.%( 0/( .06''0(*.(/( /& (/0( ('%& ('0+*0/( D.%( 0/( .06''0(*.(/(,/&,(/0(,('%&,('0+*0/(,D.%(,0/(,.06''0(*.(/(,/&,(/0(,('%&,('0+*0/(,D.%(,0/(,.06''0(

B'0+*$0$&",D$##")/%&/,($,5+),'+,/%,:"0.%H/,FB'0+*$0$&",D$##")/%&/,($,5+),'+,/%,:"0.%H/,F5)"(/%6/,D/,(.5'%'($D/(,5)"(/%6/,D/,(.5'%'($D/(, :'D$#$/,('0+*$0$&",:'D$#$/,('0+*$0$&",/7/7 F,/7&).6&$'%,D/(,.06.0'CD/(,D/,F,/7&).6&$'%,D/(,.06.0'CD/(,D/,Catharanthus Catharanthus

roseusroseus K.P:.0$6$%/MK.P:.0$6$%/M

EXTRACTION DES ALCALOIDESEXTRACTION DES ALCALOIDES

<"&3'D/,60.(($9+/,KB&.(<"&3'D/,60.(($9+/,KB&.(--f&&'M,/&,6')'00.$)/,Ff&&'M,/&,6')'00.$)/,F

!"50.6/:/%&!"50.6/:/%& D/(,.06.0'CD/(,D/,0/+),D/(,.06.0'CD/(,D/,0/+),6':*$%.$('%6':*$%.$('%5.),0J+&$0$(.&$'%,DJ+%/,*.(/,D$0+"/,F,nk5.),0J+&$0$(.&$'%,DJ+%/,*.(/,D$0+"/,F,nkNNfk@,8.KfkMfk@,8.KfkMQQ'+,n.'+,n.QQ8f8fZZ .P'+&",.+,:.&")$/0,?"H"&.0,(/6,.P'+&",.+,:.&")$/0,?"H"&.0,(/6,

;7&).6&$'%;7&).6&$'% .?/6,('0?.%&,5/+,5'0.$)/.?/6,('0?.%&,5/+,5'0.$)/ F,630')'#'):/@,F,630')'#'):/@,D$630')':"&3.%/@,"&3/)@,.6"&.&/,DJ"&320/D$630')':"&3.%/@,"&3/)@,.6"&.&/,DJ"&320/

>+$(,>+$(,5+)$#$6.&$'%,5.),/7&).6&$'%,0$9+$D/,5+)$#$6.&$'%,5.),/7&).6&$'%,0$9+$D/,-- 0$9+$D/,0$9+$D/,K('0?.%&(,K('0?.%&(,%'%,%'%,:$(6$*0/(M,.5)4(,63.%H/:/%&,D/,5k:$(6$*0/(M,.5)4(,63.%H/:/%&,D/,5k

éé éé


E)&"#.6&(E)&"#.6&( D_/7&).6&$'%,D_/7&).6&$'%,/%,5)"(/%6/,D_.6$D/,#')&,/%,5)"(/%6/,D_.6$D/,#')&,'+,D/,*.(/,#')&/,F'+,D/,*.(/,#')&/,F

;7/:50/,D/(,$)$D'CD/(,K(o")'($D/,D/,0.,H/%&$.%/M,;7/:50/,D/(,$)$D'CD/(,K(o")'($D/,D/,0.,H/%&$.%/M,($,/7&).6&$'%,/%,5)"(/%6/,D_.::'%$.9+/,6'%6/%&)"/,($,/7&).6&$'%,/%,5)"(/%6/,D_.::'%$.9+/,6'%6/%&)"/,H/%&$.%$%/,p,.06.0'CD/,.)&"#.6&H/%&$.%$%/,p,.06.0'CD/,.)&"#.6&

O

O

Glucose

O

EXTRACTION DES ALCALOIDES

8.(,D/(,8.(,D/(,.06.0'CD/(,#.$*0/:/%&,*.($9+/(,.06.0'CD/(,#.$*0/:/%&,*.($9+/(,F,F,/7/:50/,D/,0.,6.#"$%/,/&,D/(,.+&)/(,7.%&3$%/(,/7/:50/,D/,0.,6.#"$%/,/&,D/(,.+&)/(,7.%&3$%/(,KD"0'6.0$(.&$'%,D/(,"0/6&)'%(MKD"0'6.0$(.&$'%,D/(,"0/6&)'%(M

/7&).6&$'%,5'(($*0/,D/(,.06.0'CD/(,*.(/,5.),0_/.+,63.+D/,/7&).6&$'%,5'(($*0/,D/(,.06.0'CD/(,*.(/,5.),0_/.+,63.+D/,

CH3N

NCH3N

NCH3

O

O

CH3N

NCH3N

NH

O

O

NH

NCH3N

NCH3

O

O


E06.0'CD/(,9+.&/)%.$)/(,FE06.0'CD/(,9+.&/)%.$)/(,F;7,F,*/)*")$%/@,32D).(&$%/GG;7,F,*/)*")$%/@,32D).(&$%/GG

n/,5/+?/%&,5.(,^&)/,,,n/,5/+?/%&,5.(,^&)/,,,/7&).$&(,(/0'%,0.,:"&3'D/,/7&).$&(,(/0'%,0.,:"&3'D/, N

+

O

D/,B&.(D/,B&.(--f&&'f&&'

#'):/,*.(/,#'):/,*.(/,F,fkF,fk-- /&,/&, #'):/,(/0,#'):/,(/0,F,80F,80-- kkdd

&'+P'+)(,&'+P'+)(,D$(('6$"(,D$(('6$"(,

&'+P'+)(,('0+*0/(,D.%(,0_/.+,&'+P'+)(,('0+*0/(,D.%(,0_/.+,/&,$%('0+*0/(,D.%(,0/(,('0?.%&(,')H.%$9+/(/&,$%('0+*0/(,D.%(,0/(,('0?.%&(,')H.%$9+/(

NO

OMe

OMe

EXTRACTION DES ALCALOIDES

E06.0'CD/(,53"%'0$9+/(,E06.0'CD/(,53"%'0$9+/(,K,:')53$%/,M,FK,:')53$%/,M,F

OH

V'):.&$'%,D/,53"%.&/,/%,V'):.&$'%,D/,53"%.&/,/%,

n/,5/+?/%&,5.(,^&)/,/7&).$&,(/0'%,0.,:"&3'D/,D/,B&.(n/,5/+?/%&,5.(,^&)/,/7&).$&,(/0'%,0.,:"&3'D/,D/,B&.(--f&&'f&&'

NCH3OH

O55

:$0$/+,.06.0$%,:$0$/+,.06.0$%, 5.((.H/,/%,5.((.H/,/%,53.(/,.9+/+(/,53.(/,.9+/+(/, .+&)/(,.+&)/(,.06.0'CD/(,D/,0_'5$+:.06.0'CD/(,D/,0_'5$+:


U&$0$(.&$'%(,D/,)".6&/+)(,D/,H).%D/,&.$00/U&$0$(.&$'%(,D/,)".6&/+)(,D/,H).%D/,&.$00/

8/)&.$%(,('0?.%&(,$%&/)D$&(,K&'7$6$&"@,#0.::.*$0$&"@8/)&.$%(,('0?.%&(,$%&/)D$&(,K&'7$6$&"@,#0.::.*$0$&"@D.%H/) DJ/750'($'%MD.%H/) DJ/750'($'%M

;7&).6&$'%,$%D+(&)$/00/,F;7&).6&$'%,$%D+(&)$/00/,F

D.%H/),D /750'($'%MD.%H/),D /750'($'%M

8'%D$&$'%(,"6'%':$9+/(,/&,5).&$9+/(,D"&/):$%.%&/(8'%D$&$'%(,"6'%':$9+/(,/&,5).&$9+/(,D"&/):$%.%&/(

j/63/)63/,D/,5)'6"D"(,5.)&$6+0$/)(,F,)".6&$'%(,j/63/)63/,D/,5)'6"D"(,5.)&$6+0$/)(,F,)".6&$'%(,D.%(,0/,:$0$/+@,5)"6$5$&.&$'%(,("0/6&$?/(,LGD.%(,0/,:$0$/+@,5)"6$5$&.&$'%(,("0/6&$?/(,LG


;7&).6&$'%,D/,0J.P:.0$6$%/,;7&).6&$'%,D/,0J.P:.0$6$%/,D/(,).6$%/(,D/,D/(,).6$%/(,D/,Rauwolfia serpentinaRauwolfia serpentina Ki.*G,>$/))/,V.*)/M,FKi.*G,>$/))/,V.*)/M,F

N

OHOH

NMe

C2H5

EP:.0$6$%/,K,p,).+*.($%/,M,EP:.0$6$%/,K,p,).+*.($%/,M, ..6&$#,%$?/.+,?.(6+0.$)/,6")"*).06&$#,%$?/.+,?.(6+0.$)/,6")"*).0

>)"(/%&/,/%,:"0.%H/,.?/6,.06.0'CD/(,%'%,$%&")/((.%&(,F>)"(/%&/,/%,:"0.%H/,.?/6,.06.0'CD/(,%'%,$%&")/((.%&(,F(/)5/%&$%/,K,*.(/,#')&/,M@,)"(/)5$%/@,*.(/(,#.$*0/(,GG,(/)5/%&$%/,K,*.(/,#')&/,M@,)"(/)5$%/@,*.(/(,#.$*0/(,GG,


N+

ON -

MeOOC

N

MeOOC

NH OMe

COO OMe

OMeOMe

EXTRACTION DE L'AJMALICINE DES RACINES DE CATHARANTHUS ROSEUS

11

Thomas DI PASCOLI

Le NaBH4 empèche les oxydation des alcaloïdes.

j".6&$'%(,D/,6':50/7.&$'%,j".6&$'%(,D/,6':50/7.&$'%,FFKK5)"6$5$&.&$'%@,6'0').&$'%M5)"6$5$&.&$'%@,6'0').&$'%M1.("/(,(+),6.5.6$&",D/,6':*$%.$('%,.?/6,:"&.+7,/&,1.("/(,(+),6.5.6$&",D/,6':*$%.$('%,.?/6,:"&.+7,/&,:"&.0'CD/(,F,1$@,kH@,q@,[:"&.0'CD/(,F,1$@,kH@,q@,[

]'+P'+)(,/%,:$0$/+,.9+/+7,.6$D/]'+P'+)(,/%,:$0$/+,.9+/+7,.6$D/ FF

MISE EN ÉVIDENCE DES ALCALOIDES

P 9P 9<.2/),F,:/)6+)$$'D+)/,D/,r,K*0.%63s&)/M<.2/),F,:/)6+)$$'D+)/,D/,r,K*0.%63s&)/M

!).H/%D')##,F,$'D'*$(:+&3$&/,D/,r,K)'+H/,').%H"M!).H/%D')##,F,$'D'*$(:+&3$&/,D/,r,K)'+H/,').%H"M F,F,.+(($,/%,88<.+(($,/%,88<

1'+63.)D.&F,$'D+)/,D/,r,$'D",K*)+%M1'+63.)D.&F,$'D+)/,D/,r,$'D",K*)+%M

E&&/%&$'%,.+7,#.+7,5'($&$#(,F,E&&/%&$'%,.+7,#.+7,5'($&$#(,F,6'+:.)$%/(@,32D)'726'+:.)$%/(@,32D)'72--#0.?'%/(@,>;Y@,#0.?'%/(@,>;Y@,(.5'%$%/((.5'%$%/(

DOSAGE PHARMACOPEE

!'(.H/,D/(,.06.0'CD/(,&'&.+7,F<"&3'D/,H).?$:"&)$9+/,.*.%D'%%"/

<"&3'D/,?'0+:"&)$9+/,F,.6$D$:"&)$/,/%,)/&'+),.5)4(,/7&).6&$'%,/%,:$0$/+,.06.0$%,KB'0.%.6"/(M

!'(.H/,D_+%,6'%(&$&+.%&,'+,H)G,D/,6'%(&$&+.%&(,F]/63%$9+/(,(5/6&)'53'&':"&)$9+/(,F.06.0'CD/(,9+$%9+$%.,F,.*(')*.%6/,=,Q, (/0'%,(&)+6&+)/

!'(.H/,6'0')$:"&)$9+/,F*.(/(,#.$*0/(,D.%(,).6$%/,D/,Rauwolfia,

!'(.H/,5.),63)':.&'H).53$/,0$9+$D/,F,6.#"$%/@,:')53$%/GG,

MONOGRAPHIESMONOGRAPHIESPlantes à alcaloïdesPlantes à alcaloïdes

\G <.&$4)/(,5)/:$4)/(,=,6.#"$%/Q >.?'& '5$+: /& :')53$%/QG >.?'&@,'5$+:,/&,:')53$%/ZG A+$%9+$%.,/&,9+$%$%/NG B'0.%.6"/(,=,.06.0'CD/(,&)'5.%$9+/(WG >0.%&/(,=,.06.0'CD/(,.%&$&+:').+7

Matières premières à caféineMatières premières à caféine

CAFE ET CAFEINECAFE ET CAFEINE

8.#"$/),%.&$#,D/,0_E#)$9+/,D/,0_/(&,K(5G,8.#"$/),%.&$#,D/,0_E#)$9+/,D/,0_/(&,K(5G,arabicaarabicaM,/&,*.(($%M,/&,*.(($%D+,8'%H',K(5G,D+,8'%H',K(5G,canephoracanephoraMM

]'))"#$6.&$'%,/&,5)"5.).&$'%,D+,*)/+?.H/,D_')$H$%/,,,]'))"#$6.&$'%,/&,5)"5.).&$'%,D+,*)/+?.H/,D_')$H$%/,,,.).*/.).*/ ;+)'5/ = 0. #$% D+ <'2/%;+)'5/ = 0. #$% D+ <'2/%--.H/ K\S.H/ K\S4:/4:/ ($460/M($460/M

U%/,6'+)&/,3$(&'$)/,D+,6.#",,,,U%/,6'+)&/,3$(&'$)/,D+,6.#",,,,

.).*/,.).*/, ;+)'5/,=,0.,#$%,D+,<'2/%;+)'5/,=,0.,#$%,D+,<'2/% .H/,K\S.H/,K\S ($460/M($460/M

8+0&+)/,0'%H&/:5(,+%,:'%'5'0/,D/,0.,5"%$%(+0/,8+0&+)/,0'%H&/:5(,+%,:'%'5'0/,D/,0.,5"%$%(+0/,.).*$9+/,.).*$9+/,

8+0&+)/,)/5)$(/,5.),0/(,V).%t.$(,/&,0/(,k'00.%D.$(,8+0&+)/,)/5)$(/,5.),0/(,V).%t.$(,/&,0/(,k'00.%D.$(,D.%(,0/+)(,6'0'%$/(D.%(,0/+)(,6'0'%$/(

E6&+/00/:/%&,0.,(/6'%D/,)/(('+)6/,6'::/)6$.0/,.+,E6&+/00/:/%&,0.,(/6'%D/,)/(('+)6/,6'::/)6$.0/,.+,:'%D/,.5)4(,0/,5"&)'0/,K1)"($0@,8'0':*$/,LM:'%D/,.5)4(,0/,5"&)'0/,K1)"($0@,8'0':*$/,LM

Dispersion géographique de la culture Dispersion géographique de la culture du caféierdu caféier

U%/,6/%&.$%/,D_/(546/(,D/,U%/,6/%&.$%/,D_/(546/(,D/,Coffea Coffea Kj+*$.6"/(M,,,Kj+*$.6"/(M,,,%.&$?/(,5'+),0.,50+5.)&,D_E#)$9+/@,5'+((.%&,D.%(,%.&$?/(,5'+),0.,50+5.)&,D_E#)$9+/@,5'+((.%&,D.%(,D/(,3.*$&.&(,&)'5$6.+7,'+,(+*D/(,3.*$&.&(,&)'5$6.+7,'+,(+*--&)'5$6.+7&)'5$6.+7

A+.&)/,/(546/(,$:5')&.%&/(,D_+%,5'$%&,D/,?+/,,A+.&)/,/(546/(,$:5')&.%&/(,D_+%,5'$%&,D/,?+/,,6'::/)6$.06'::/)6$.0

ASPECTS BOTANIQUES ASPECTS BOTANIQUES

6'::/)6$.0,F6'::/)6$.0,F

Coffea arabicaCoffea arabica iG,iG, SW,X,5)'D+6&$'%,:'%D$.0/SW,X,5)'D+6&$'%,:'%D$.0/

S,S,-- h,:'$(,/%&)/,0.,#0').$('%,/&,0.,:.&+).&$'%h,:'$(,/%&)/,0.,#0').$('%,/&,0.,:.&+).&$'%

D/+7,('+(D/+7,('+(--/(546/(,F,/(546/(,F,

?.)G,?.)G,arabicaarabica F,1)"($0@,E#)$9+/,D/,0_/(&@,E($/F,1)"($0@,E#)$9+/,D/,0_/(&@,E($/?.)G,?.)G,bourbon bourbon F,6.#",D_.0&$&+D/,Ki.,j"+%$'%MF,6.#",D_.0&$&+D/,Ki.,j"+%$'%M

Coffea canephora Coffea canephora >$/))/,>$/))/, .55/0",.55/0",6.#",6.#",robustarobustauu ZO,X,D/,0.,5)'D+6&$'%,:'%D$.0/,K$%(&.%&.%"MZO,X,D/,0.,5)'D+6&$'%,:'%D$.0/,K$%(&.%&.%"Muu b,b,-- \\,:'$(,D/,0.,#0').$('%,=,0.,:.&+).&$'%\\,:'$(,D/,0.,#0').$('%,=,0.,:.&+).&$'%uu 6.#",D/,v*.((/,&/))/w,KE#)$9+/,"9+.&')$.0/M6.#",D/,v*.((/,&/))/w,KE#)$9+/,"9+.&')$.0/Muu ?$H'+)/+7@,)"($(&.%&,.+7,:.0.D$/(@,6.#"$%/,?$H'+)/+7@,)"($(&.%&,.+7,:.0.D$/(@,6.#"$%/,

ASPECTS BOTANIQUESASPECTS BOTANIQUES

uu .)x:/,/&,H'y&,$%#")$/+)(,=,.)x:/,/&,H'y&,$%#")$/+)(,=,C. arabicaC. arabica

C. excelsaC. excelsa EG,83/?GEG,83/?Guu ?$H'+)/+7@,)"($(&.%&,.+7,:.0.D$/(,/&,("63/)/((/?$H'+)/+7@,)"($(&.%&,.+7,:.0.D$/(,/&,("63/)/((/

C. libericaC. liberica qG,1+00G,;7,k$/)%qG,1+00G,;7,k$/)%uu \N,:'$(,D/,0.,#0').$('%,=,0.,:.&+).&$'%\N,:'$(,D/,0.,#0').$('%,=,0.,:.&+).&$'%uu H).$%(,D/,H).%D/,&.$00/,H).$%(,D/,H).%D/,&.$00/,uu \X,D/,0.,5)'D+6&$'%,:'%D$.0/\X,D/,0.,5)'D+6&$'%,:'%D$.0/

Répartition des espèces Répartition des espèces

>/&$&,.)*)/,F>/&$&,.)*)/,F

V/+$00/(,/%&$4)/(,5/)($(&.%&/(@,V/+$00/(,/%&$4)/(,5/)($(&.%&/(@,6')$.6/(@,0+$(.%&/(6')$.6/(@,0+$(.%&/(

LA PLANTE

V0/+)(,*0.%63/(,'D').%&/(,/%V0/+)(,*0.%63/(,'D').%&/(,/%?/)&$6$00/(?/)&$6$00/(

!)+5/,6':5')&.%&,Q,H).$%/(,!)+5/,6':5')&.%&,Q,H).$%/(,.66'0"/(,?/)&/,.66'0"/(,?/)&/, )'+H/,=,)'+H/,=,:.&+)$&":.&+)$&"

Caféier en fleurCaféier en fleur

Drupe en voie de maturationDrupe en voie de maturation

LA RECOLTE DU CAFE LA RECOLTE DU CAFE

LA DROGUE VÉGÉTALE LA DROGUE VÉGÉTALE

Structure du fruit et de la graine Structure du fruit et de la graine du du caféier :caféier :\F,($00'%,6/%&).0,\F,($00'%,6/%&).0,QF,H).$%,D/,6.#",K/%D'(5/):/M,QF,H).$%,D/,6.#",K/%D'(5/):/M,ZF,5/.+,D+,H).$%,K&"H+:/%&M,ZF,5/.+,D+,H).$%,K&"H+:/%&M,NF,5.)63/,K/%D'6.)5/M,NF,5.)63/,K/%D'6.)5/M,WF,6'+63/,D/,:+6$0.H/(,WF,6'+63/,D/,:+6$0.H/(,SF,5+05/,K:"('6.)5/M,SF,5+05/,K:"('6.)5/M,RF,5/.+,D+,#)+$&,K/7'6.)5/M,RF,5/.+,D+,#)+$&,K/7'6.)5/M,

f*&/%&$'%,D+,6.#",v/%,H).$%w,F,f*&/%&$'%,D+,6.#",v/%,H).$%w,F,K,:"&3'D/(,3+:$D/,'+,(463/,MK,:"&3'D/(,3+:$D/,'+,(463/,M

!"5+05.H/,!"5+05.H/,F,"0$:$%.&$'%,/7'6.)5/,F,"0$:$%.&$'%,/7'6.)5/,)'+H/,/&,:"('6.)5/,63.)%+)'+H/,/&,:"('6.)5/,63.)%+

!"5.)63.H/!"5.)63.H/ F "0$:$%.&$'% /%D'6.)5/F "0$:$%.&$'% /%D'6.)5/

LA DROGUE VÉGÉTALE

!"5.)63.H/,!"5.)63.H/,F,"0$:$%.&$'%,/%D'6.)5/,F,"0$:$%.&$'%,/%D'6.)5/,(60")$#$",(60")$#$", v#4?/w,p,H).$%/,D/,6.#"v#4?/w,p,H).$%/,D/,6.#"

i.,H).$%/,K6.#",?/)&M,Fi.,H).$%/,K6.#",?/)&M,F'?.0/@,6'%?/7/,(+),#.6/,D')(.0/@'?.0/@,6'%?/7/,(+),#.6/,D')(.0/@.50.&$/,(+),#.6/,?/%&).0/.50.&$/,(+),#.6/,?/%&).0/($00'%,0'%H$&+D$%.0,p,3$0/($00'%,0'%H$&+D$%.0,p,3$0/D+)/,/&,?/)Ds&)/@,$%'D')/D+)/,/&,?/)Ds&)/@,$%'D')/ «« fèvefève » avant torréfaction» avant torréfaction

Drupes de caféDrupes de café

Thomas DI PASCOLI

Tégument fait encore partie de la graine alors que le reste autour fait parti du fruit.

robustaarabica

Café vert :Café vert :WO,X,WO,X,H0+6$D/(H0+6$D/( K(+6)/(,d,5'02(.663.)$D/(M,K(+6)/(,d,5'02(.663.)$D/(M,

\\,X,\\,X,5)'&"$%/(5)'&"$%/(

\O\O \W X\W X 0$5$D/(0$5$D/( K(&")'0( &'6'53")'0( .06''0(K(&")'0( &'6'53")'0( .06''0(

CARACTÈRES CHIMIQUESCARACTÈRES CHIMIQUES

\O,\O,-- \W,X,\W,X,0$5$D/(0$5$D/( K(&")'0(@,&'6'53")'0(@,.06''0(,K(&")'0(@,&'6'53")'0(@,.06''0(,D$&/)5"%$9+/(,0$*)/(,/&,/(&")$#$"(MD$&/)5"%$9+/(,0$*)/(,/&,/(&")$#$"(M

W,W,-- hX,/%?$)'%,D_hX,/%?$)'%,D_.6$D/(,53"%'0(,.6$D/(,53"%'0(,/&,D")$?"(,/&,D")$?"(,K630')'H"%$9+/@,6.#"$9+/MK630')'H"%$9+/@,6.#"$9+/M

O@S,O@S,-- Z,X,D/,Z,X,D/,6.#"$%/6.#"$%/ (/0'%,?.)$"&"(,d,&).6/(,D/,(/0'%,?.)$"&"(,d,&).6/(,D/,&3"'*)':$%/&3"'*)':$%/

Thomas DI PASCOLI

- La voie humide consiste en plusieurs opérations de triages pour contrôle qualité, etc.Les druppes qui ne sont pas développée ou attaqué par des insectes vont flotter on enlève la pulpe et l'exocarpe avec des dépulpeuses mais il restera les mucilage et donc on fait fermenter la druppe pour une meilleure conservation du café et donc dégradation des mucilages. Puis lavage et séchage et décortication du parche par des moulin, etc et on aura du café vert. - la voie sèche pour le robusta ne donne pas un café d'une aussi bonne qualité.

Thomas DI PASCOLI

Donne l'amertume du café et non à la différence en caféine.

i/(,&/%/+)(,/%,.6$D/(,53"%'0(,/&,6.#"$%/ )/%(/$H%/%&,(+),0_.:/)&+:/,D+,6.#",?/)&,F,

0.,&/%/+),/%,.6$D/(,630')'H"%$9+/(,D'$&,(/,($&+/),/%&)/,R,/&,h,X,0. &/%/+) /% 6.#"$%/ 5'+) +% arabica D'$& ^&)/ z \ NO X

CARACTÈRES SENSORIELS CARACTÈRES SENSORIELS DU CAFÉ VERT MARCHANDDU CAFÉ VERT MARCHAND

0.,&/%/+),/%,6.#"$%/@,5'+),+%,arabica@,D'$&,^&)/,z,\@NO,X

<.&$4)/,H).((/, #$7.&/+),D_.)x:/(F,?.0/+)( 6':5)$(/(,/%&)/,\O,X,KrobustaM,/&,\W,X,KarabicaM]/%/+),/%,(.663.)'(/ D"5/%D,D/,0.,:.&+)$&",/&,D+,&).$&/:/%&,5'(&-)"6'0&/F,&.+7,D/,(.663.)'(/,*.(,%$?/.+,.)':.&$9+/,#.$*0/i.,&/%/+),/%,/.+,D'$&,.?'$),D/(,?.0/+)(,z,\O@W,X

>/)&/,D_3+:$D$&",/&,)".6&$'%(,D/,<.$00.)D,>/)&/,D_3+:$D$&",/&,)".6&$'%(,D/,<.$00.)D, +&$0$(.&$'%,+&$0$(.&$'%,D/(,(+6)/(,/&,D/(,5)'&$D/(,K.6G,.:$%"(M,D+,H).$%,5'+),D/(,(+6)/(,/&,D/(,5)'&$D/(,K.6G,.:$%"(M,D+,H).$%,5'+),#'):/),0/(,%':*)/+(/(,:'0"6+0/(,D/,0_#'):/),0/(,%':*)/+(/(,:'0"6+0/(,D/,0_.)x:/.)x:/@,.$%($,@,.$%($,9+/,D/(,9+/,D/(,6':5'("(,5'02:")$("(,*)+%(6':5'("(,5'02:")$("(,*)+%(i.,&'))"#.6&$'%,(/,D")'+0/,D.%(,D/(,(2(&4:/(,/%,i.,&'))"#.6&$'%,(/,D")'+0/,D.%(,D/(,(2(&4:/(,/%,6'%&$%+ ('+( .$) 63.+D 5+0("6'%&$%+ ('+( .$) 63.+D 5+0("

LA TORRÉFACTIONLA TORRÉFACTION

6'%&$%+,('+(,.$),63.+D,5+0(",6'%&$%+,('+(,.$),63.+D,5+0(",

;00/,D+)/,D/,;00/,D+)/,D/,\O,=,QO,:$%+&/(,\O,=,QO,:$%+&/(,=,D/(,&=,D/(,&{{ 6':5)$(/(,6':5)$(/(,/%&)/,/%&)/,QOO,/&,QhO,QOO,/&,QhO,{{888_/(&,0/,6'+50/,D+)"/8_/(&,0/,6'+50/,D+)"/--&/:5").&+)/,9+$,D"&/):$%/,0/(,&/:5").&+)/,9+$,D"&/):$%/,0/(,5)$%6$5.0/(,6.).6&")$(&$9+/(,D+,6.#",F5)$%6$5.0/(,6.).6&")$(&$9+/(,D+,6.#",F

H).$%(,*0'%D(,D/(,6.#"(,5/+,&'))"#$"(,KE00/:.H%/@,UBEM,H).$%(,*0'%D(,D/(,6.#"(,5/+,&'))"#$"(,KE00/:.H%/@,UBEM,H).$%(,*)+%(,.)':.&$9+/(,D/(,6.#"(,#).%t.$(,H).$%(,*)+%(,.)':.&$9+/(,D/(,6.#"(,#).%t.$(,H).$%(,5)/(9+/,%'$)(,D/(,6.#"(,$&.0$/%(@,#')&/:/%&,&'))"#$"(H).$%(,5)/(9+/,%'$)(,D/(,6.#"(,$&.0$/%(@,#')&/:/%&,&'))"#$"(

E:/)&+:/,/&,.6$D$&",E:/)&+:/,/&,.6$D$&", 550+(,0/,6.#",/(&,&'))"#$"@,50+(,0+(,0/,6.#",/(&,&'))"#$"@,50+(,0_.:/)&+:/,.+H:/%&/,/&,50+(,0_.6$D$&",D$:$%+/,F,0_$D".0,0_.:/)&+:/,.+H:/%&/,/&,50+(,0_.6$D$&",D$:$%+/,F,0_$D".0,/(&,D_.?'$),+%,5.)#.$&","9+$0$*)/,/%&)/,0/(,D/+7,(.?/+)(/(&,D_.?'$),+%,5.)#.$&","9+$0$*)/,/%&)/,0/(,D/+7,(.?/+)(

>3"%':4%/(,532($9+/(,.+,6'+)(,D/,0.,&'))"#.6&$'%,>3"%':4%/(,532($9+/(,.+,6'+)(,D/,0.,&'))"#.6&$'%,*)+%$((/:/%&,D/(,H).$%(,Dy,.+7,)".6&$'%(,D/,<.$00.)D*)+%$((/:/%&,D/(,H).$%(,Dy,.+7,)".6&$'%(,D/,<.$00.)D

#0 & KD SO = hO XM " &$ D & D#0 & KD SO = hO XM " &$ D & D

LA TORRÉFACTIONLA TORRÉFACTION

H'%#0/:/%&,KD/,SO,=,hO,XM@,5.),6)".&$'%,D/,5')/(,/&,D/,H'%#0/:/%&,KD/,SO,=,hO,XM@,5.),6)".&$'%,D/,5')/(,/&,D/,6.?$&"(,)"(+0&.%&,D/(,53"%':4%/(,D/,D"H.e.H/@,/&,+%/6.?$&"(,)"(+0&.%&,D/(,53"%':4%/(,D/,D"H.e.H/@,/&,+%/5/)&/,D/,5'$D(,D/,\W,=,QO,X@,6.+("/,5.),0/,D"5.)&,D/,0_/.+,5/)&/,D/,5'$D(,D/,\W,=,QO,X@,6.+("/,5.),0/,D"5.)&,D/,0_/.+,/&,D+,H.e,6.)*'%$9+//&,D+,H.e,6.)*'%$9+/

E%.02(/,63$:$9+/,D+,6.#",&'))"#$",E%.02(/,63$:$9+/,D+,6.#",&'))"#$",FF&/%/+),/%,/.+,&/%/+),/%,/.+, Kz,\,XMKz,\,XM32D)'02(/,D/(,5'02(.663.)$D/(32D)'02(/,D/(,5'02(.663.)$D/(.)x:/,6':50/7/,K50+($/+)(,6/%&.$%/(,D/,6':5'("(M.)x:/,6':50/7/,K50+($/+)(,6/%&.$%/(,D/,6':5'("(M&/%/+),/%,6.#"$%/,5/+,:'D$#$"/&/%/+),/%,6.#"$%/,5/+,:'D$#$"/

Thomas DI PASCOLI

C'est les variation de ces paramètres qui va donner les différents gouts des café.

LA DÉCAFEINISATION DU CAFÉLA DÉCAFEINISATION DU CAFÉ

i/,6.#",?/)&,D"6.#"$%",D'$&,6'%&/%$),z,O@Ob,X,D/,,i/,6.#",?/)&,D"6.#"$%",D'$&,6'%&/%$),z,O@Ob,X,D/,,6.#"$%/,/&,0/,6.#",&'))"#$",D"6.#"$%", ,O@\,X,D/,,6.#"$%/,/&,0/,6.#",&'))"#$",D"6.#"$%", ,O@\,X,D/,,6.#"$%/,6.#"$%/,K%'):/,#).%t.$(/MK%'):/,#).%t.$(/M

U%/,&.((/,D/,6.#",D"6.#"$%",6'%&$/%&,\W,#'$(,:'$%(U%/,&.((/,D/,6.#",D"6.#"$%",6'%&$/%&,\W,#'$(,:'$%(D/,6.#"$%/,9+_+%/,&.((/,D_D/,6.#"$%/,9+_+%/,&.((/,D_arabicaarabica

i.,i.,D"6.#"$%.&$'%D"6.#"$%.&$'% (/,#.$&,&'+P'+)(,(/,#.$&,&'+P'+)(,(+),0/,6.#",?/)&,(+),0/,6.#",?/)&,6.),6.),'%,('+3.$&/,F'%,('+3.$&/,F)/&$)/),(/+0/:/%&,0.,6.#"$%/,/&,0/,:'$%(,5'(($*0/,D/,)/&$)/),(/+0/:/%&,0.,6.#"$%/,/&,0/,:'$%(,5'(($*0/,D/,6':5'("(,?'0.&$0/(,.)':.&$9+/(6':5'("(,?'0.&$0/(,.)':.&$9+/(

*"%"#$6$/),D/,0.,63.0/+),D/,0.,&'))"#.6&$'%,5'+),("63/),*"%"#$6$/),D/,0.,63.0/+),D/,0.,&'))"#.6&$'%,5'+),("63/),0/,6.#",3+:$D$#$",5.),0.,D"6.#"$%.&$'%,0/,6.#",3+:$D$#$",5.),0.,D"6.#"$%.&$'%,

LA DECAFEINISATION DU CAFELA DECAFEINISATION DU CAFE

!"6.#"$%.&$'%,=,0_/.+,F,!"6.#"$%.&$'%,=,0_/.+,F,i/(($?.H/,=,63.+D,D/(,H).$%(,?/)&(,('+(,5)/(($'%i/(($?.H/,=,63.+D,D/(,H).$%(,?/)&(,('+(,5)/(($'%

>+$(,("63.H/,=,0_.$),63.+D,/&,&'))"#$6.&$'%>+$(,("63.H/,=,0_.$),63.+D,/&,&'))"#$6.&$'%

[0,/7$(&/,&)'$(,:"&3'D/(,F

!"6.#"$%.&$'%,5.),('0?.%&,630')",K8k!"6.#"$%.&$'%,5.),('0?.%&,630')",K8kQQ8080QQMMi/(($?.H/,5.),('0?.%&(,630')"(,D/(,H).$%(,?/)&(,5)"i/(($?.H/,5.),('0?.%&(,630')"(,D/(,H).$%(,?/)&(,5)"--3+:$D$#$"(3+:$D$#$"(

;0$:$%.&$'%,D+,('0?.%&,5.),"?.5').&$'%@,5+$(,5.),/%&).g%/:/%&,=,;0$:$%.&$'%,D+,('0?.%&,5.),"?.5').&$'%@,5+$(,5.),/%&).g%/:/%&,=,0.,?.5/+)@,("63.H/,D/(,H).$%(,=,0_.$),63.+D@,5+$(,&'))"#$6.&$'%0.,?.5/+)@,("63.H/,D/(,H).$%(,=,0_.$),63.+D@,5+$(,&'))"#$6.&$'%

!"6.#"$%.&$'%,.+,8f!"6.#"$%.&$'%,.+,8fQQ (+5/)6)$&$9+/(+5/)6)$&$9+/B+),D/(,H).$%(,?/)&(,5)".0.*0/:/%&,3+:$D$#$"(B+),D/(,H).$%(,?/)&(,5)".0.*0/:/%&,3+:$D$#$"(

LE CAFÉ SOLUBLELE CAFÉ SOLUBLE[0,(/,5)"5.)/,$%D+(&)$/00/:/%&,=,5.)&$),D/,6.#",[0,(/,5)"5.)/,$%D+(&)$/00/:/%&,=,5.)&$),D/,6.#",:'+0+@,5.),/7&).6&$'%,('0$D/|0$9+$D/,:'+0+@,5.),/7&).6&$'%,('0$D/|0$9+$D/, 6'%#/6&$'%,6'%#/6&$'%,D_+%,/7&).$&,.9+/+7,&)4(,6'%6/%&)"@,D_.(5/6&,D_+%,/7&).$&,.9+/+7,&)4(,6'%6/%&)"@,D_.(5/6&,($)+5/+7,($)+5/+7,8/& /7&).$& /(& /%(+$&/ 6':504&/:/%& D"(32D).&"8/& /7&).$& /(& /%(+$&/ 6':504&/:/%& D"(32D).&"8/&,/7&).$&,/(&,/%(+$&/,6':504&/:/%&,D"(32D).&"@,8/&,/7&).$&,/(&,/%(+$&/,6':504&/:/%&,D"(32D).&"@,('$&,5.),.&':$(.&$'%@,('$&,5.),02'53$0$(.&$'%,F('$&,5.),.&':$(.&$'%@,('$&,5.),02'53$0$(.&$'%,F

5.),.&':$(.&$'%,5.),.&':$(.&$'%,F,5+0?")$(.&$'%,K:$6)'H'+&&/0/&&/(M,F,5+0?")$(.&$'%,K:$6)'H'+&&/0/&&/(M,D.%(,+%,6'+).%&,D_.$),63.+D,D.%(,+%,6'+).%&,D_.$),63.+D, H).%+0"(@,D/,5'&/%&$/0,H).%+0"(@,D/,5'&/%&$/0,.)':.&$9+/,$%#")$/+).)':.&$9+/,$%#")$/+)

5.),02'53$0$(.&$'%,5.),02'53$0$(.&$'%,F,(+*0$:.&$'%,D/(,5.$00/&&/(,D/,F,(+*0$:.&$'%,D/(,5.$00/&&/(,D/,0_/7&).$&,D/,6.#",6'%H/0"0_/7&).$&,D/,6.#",6'%H/0"

PRODUCTION MONDIALE DE CAFEPRODUCTION MONDIALE DE CAFE

ASPECTS PHARMACOLOGIQUES ASPECTS PHARMACOLOGIQUES

E6&$?$&"(,D":'%&)"/(,0$"/(,=,0.,5)"(/%6/,D/,6.#"$%/,F.%&.H'%$(&/(,D/(,)"6/5&/+)(,E\,/&,D/,6/)&.$%(,)"6/5&/+)(,EQ,D/,0J.D"%'($%/

$%3$*/,0/(,53'(53'D$/(&").(/(,.$%($,9+/,0.,

n

n n

n

f

f

8kZ

8kZ

8kZ

caféinecaféine

0$*").&$'%,DJ3$(&.:$%/,5.),0/(,:.(&'62&/(

.6&$'%,(&$:+0.%&/,(+),0/(,(2(&4:/(,6.)D$'-?.(6+0.$)/,/&,)/(5$).&'$)/@,/&,(+),0.,D$+)4(/

#.?')$(/,6'%6/%&).&$'%,/&,:":')$(.&$'%

.+H:/%&/,0.,D"5/%(/,"%/)H"&$9+/,

0$5'02&$9+/,5.),?'$/,/7&/)%/

U%/,9+.).%&.$%/,D/,(5"6$.0$&"(,53.):.6/+&$9+/(,/%,V).%6/,K,.(('6$.&$'%,.?/6,.%&.0H$9+/(@,0$5'02&$9+/(,0'6.+7,M

Z

ASPECTS PHARMACEUTIQUES ASPECTS PHARMACEUTIQUES

DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographie analytique du café vertMonographie analytique du café vert>3.):.6'5"/,#).%t.$(/,}>3.):.6'5"/,#).%t.$(/,}4:/4:/ "DG"DG

!)'H+/,!)'H+/,F,H).$%/,5)$?"/,D+,&"H+:/%&,/&,("63"/,D/,F,H).$%/,5)$?"/,D+,&"H+:/%&,/&,("63"/,D/,Coffea arabica Coffea arabica iG@,D/,iG@,D/,Coffea canephora Coffea canephora >$/))/,/7,V)'/3%/),/&,0/+)(,?.)$"&"(,>$/))/,/7,V)'/3%/),/&,0/+)(,?.)$"&"(,

i/,6.#",?/)&,6'%&$/%&,i/,6.#",?/)&,6'%&$/%&,.+,:$%$:+:,\@O,5'+),6/%&,D/,6.#"$%/,.+,:$%$:+:,\@O,5'+),6/%&,D/,6.#"$%/,6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/,6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/,

<$6)'(6'5$/,F,#).H:/%&(,DJ.0*+:/%,6'%&/%.%&,D/(,H'+&&/0/&&/(,<$6)'(6'5$/,F,#).H:/%&(,DJ.0*+:/%,6'%&/%.%&,D/(,H'+&&/0/&&/(,3+$0/+(/(@,D"*)$(,D/,&"H+:/%&,/&,#$*)/(,#+($#'):/(,=,5.)'$(,,,,3+$0/+(/(@,D"*)$(,D/,&"H+:/%&,/&,#$*)/(,#+($#'):/(,=,5.)'$(,,,,6.%.0$6+0"/(,6.%.0$6+0"/(,

[D/%&$&",88<,F,?$(+.0$(.&$'%,/%,U~,/&,5.),5+0?")$(.&$'%,D/,[D/%&$&",88<,F,?$(+.0$(.&$'%,/%,U~,/&,5.),5+0?")$(.&$'%,D/,)".6&$#,)".6&$#,$'D'$'D'--$'D+)",$'D+)",/%,5)"(/%6/,D/,&":'$%,6.#"$%//%,5)"(/%6/,D/,&":'$%,6.#"$%/

>/)&/,=,0.,D/(($6.&$'%,F,>/)&/,=,0.,D/(($6.&$'%,F, b,Xb,X

8/%D)/(,&'&.0/(,F,8/%D)/(,&'&.0/(,F, b,Xb,X

!'(.H/,D/,0.,6.#"$%/,5.),8ik>,!'(.H/,D/,0.,6.#"$%/,5.),8ik>,K:'D$#$6.&$'%,:'%'H).53$/,/%,K:'D$#$6.&$'%,:'%'H).53$/,/%,6'+)(,F6'+)(,F6'6'--$%P/6&$'%,$%P/6&$'%,D_"5$6.&"63'0,5'+),?")$#$/),0.,6'%#'):$&",D+,(2(&4:/M,,,,D_"5$6.&"63'0,5'+),?")$#$/),0.,6'%#'):$&",D+,(2(&4:/M,,,,

LE THEIER : Camellia sinensis (L.) Kuntze

[0,.+).$&,"&",D"6'+?/)&,5.),0J;:5/)/+),B3^%[0,.+).$&,"&",D"6'+?/)&,5.),0J;:5/)/+),B3^%--n+%H,n+%H,KQROO,.?.%&,�G8GM,F,6/,D/)%$/),(/,#$&,.55')&/),+%/,KQROO,.?.%&,�G8GM,F,6/,D/)%$/),(/,#$&,.55')&/),+%/,&.((/,DJ/.+,*'+$00.%&/,/&@,.(($(,=,0J':*)/,DJ+%,&3"$/)@,&.((/,DJ/.+,*'+$00.%&/,/&@,.(($(,=,0J':*)/,DJ+%,&3"$/)@,$0,(J.(('+5$&G,>/%D.%&,('%,('::/$0@,50+($/+)(,#/+$00/($0,(J.(('+5$&G,>/%D.%&,('%,('::/$0@,50+($/+)(,#/+$00/((/ D"&.634)/%& 5'+) .00/) (/ 5'(/) D.%( 0J/.+ *)y0.%&/(/ D"&.634)/%& 5'+) .00/) (/ 5'(/) D.%( 0J/.+ *)y0.%&/

U%/,6'+)&/,3$(&'$)/,D+,&3",U%/,6'+)&/,3$(&'$)/,D+,&3",

(/,D"&.634)/%&,5'+),.00/),(/,5'(/),D.%(,0J/.+,*)y0.%&/(/,D"&.634)/%&,5'+),.00/),(/,5'(/),D.%(,0J/.+,*)y0.%&/0/,&3","&.$&,%"0/,&3","&.$&,%"

i/,&3"$/),.55.)&$/%&,=,0.,#.:$00/,D/(,]/)%(&)'/:$.6"/(i/,&3"$/),.55.)&$/%&,=,0.,#.:$00/,D/(,]/)%(&)'/:$.6"/(K]3".6"/(MK]3".6"/(Mf%,D$(&$%H+/,D/+7,?.)$"&"(,5)$%6$5.0/(,Ff%,D$(&$%H+/,D/+7,?.)$"&"(,5)$%6$5.0/(,F

Camellia sinensis sinensisCamellia sinensis sinensis K,83$%/@,�.5'%@,j+(($/@,[).%@]+)9+$/K,83$%/@,�.5'%@,j+(($/@,[).%@]+)9+$/Camellia sinensis assamicaCamellia sinensis assamica K,%')DK,%')D--/(&,D/,0J[%D/,M/(&,D/,0J[%D/,M

LE THEIER : Camellia sinensisLE THEIER : Camellia sinensis

8+0&$?",D.%(,0/(,5.2(,D+,8+0&$?",D.%(,0/(,5.2(,D+,(+D(+D--/(&,.($.&$9+/,/(&,.($.&$9+/,:.$(,.+(($,(+),0/,6'%&$%/%&,.#)$6.$%@,/%,:.$(,.+(($,(+),0/,6'%&$%/%&,.#)$6.$%@,/%,]+)9+$/,'+,/%6')/,/%,E)H/%&$%/]+)9+$/,'+,/%6')/,/%,E)H/%&$%/

>/&$&,.)*)/,).:/+7>/&$&,.)*)/,).:/+7@,=,#/+$00/(,5/)($(&.%&/(@@,=,#/+$00/(,5/)($(&.%&/(@:'00/(,/&,D+?/&/+(/(,0')(9+J/00/(,('%&,:'00/(,/&,D+?/&/+(/(,0')(9+J/00/(,('%&,P/+%/( 6')$.6/( /& 5)/(9+/ H0.*)/(P/+%/( 6')$.6/( /& 5)/(9+/ H0.*)/(P/+%/(@,6')$.6/(,/&,5)/(9+/,H0.*)/(,P/+%/(@,6')$.6/(,/&,5)/(9+/,H0.*)/(,0')(9+J/00/(,('%&,sH"/(,K(60")$&/(M0')(9+J/00/(,('%&,sH"/(,K(60")$&/(M

;%,6+0&+)/@,0/(,&3"$/)(,('%&,;%,6+0&+)/@,0/(,&3"$/)(,('%&,&.$00"(&.$00"( &)4(,&)4(,)"H+0$4)/:/%&,5'+),#.6$0$&/),0.,)"6'0&/)"H+0$4)/:/%&,5'+),#.6$0$&/),0.,)"6'0&/

n"6/(($&/,+%,n"6/(($&/,+%,/%('0/$00/:/%&/%('0/$00/:/%& D/,W,3/+)/(,D/,W,3/+)/(,:$%G,5.),P'+)@,3+:$D$&",D/,0J.$),KRO,:$%G,5.),P'+)@,3+:$D$&",D/,0J.$),KRO,-- bOXM,bOXM,/&,D/(,50+$/(,.*'%D.%&/(,K,/76/5&$'%,5'+),/&,D/(,50+$/(,.*'%D.%&/(,K,/76/5&$'%,5'+),0/(,&3"(,D_.0&$&+D/,M0/(,&3"(,D_.0&$&+D/,M

Thomas DI PASCOLI

Théacées = nouveau terme des ternstroemiacées.

LA RECOLTE DES FEUILLES DE THELA RECOLTE DES FEUILLES DE THE

k.*$&+/00/:/%&@,'%,%/,6+/$00/,9+/,0/,*'+)H/'% =,0_/7&)":$&",D/,0.,*).%63/,/&,0/(,D/+7,#/+$00/(,(+$?.%&/(,0/(,50+(,P/+%/(,)4H0/,D/(,` &o',0/.?/(,.%D,.,*+D a

;%,E#)$9+/@,'%,+&$0$(/,5.)#'$(,D/(,:.63$%/(@,$ B $ i c & [ D 0 &3" &:.$(,.+,B)$,i.%c.,/&,/%,[%D/@,0/,&3",/(&,

/%6')/,6+/$00$,=,0.,:.$%, :/$00/+)/,9+.0$&",6.),0/(,6+/$00/+)(,0.$((/%&,D/,6x&",0/(,5'+((/(,$%(+##$(.::/%&,:y)/(

E,*.((/,.0&$&+D/@,0/,&3",/(&,)"6'0&",P+(9+_=,ZO,#'$(,5.),.%@,D.%(,0/(,3.+&/+)(@,` (/+0/:/%& a,\W,#'$(@,6.),$0,5'+((/,50+(,0/%&/:/%&

LE THEIER : CAMELLIA SINENSISLE THEIER : CAMELLIA SINENSIS

8'::/)6$.0/:/%&@,'%,D$(&$%H+/,8'::/)6$.0/:/%&@,'%,D$(&$%H+/,(+)&'+&,,F(+)&'+&,,F

]3",*0.%6,]3",*0.%6,F,(&.*$0$(",=,0.,?.5/+),,/&,("63"F,(&.*$0$(",=,0.,?.5/+),,/&,("63"

]3",?/)&]3",?/)&@,#s%",5+$(,(&.*$0$(",5.),0.,63.0/+)@,#s%",5+$(,(&.*$0$(",5.),0.,63.0/+)(463/,'+,5.),0.,?.5/+)@,)'+0"@,("63",,(463/,'+,5.),0.,?.5/+)@,)'+0"@,("63",,5 5 @ @5 5 @ @).5$D/:/%&,/&,50+(,'+,:'$%(,&'))"#$"@,).5$D/:/%&,/&,50+(,'+,:'$%(,&'))"#$"@,K(+)&'+&,6'%('::",/%,83$%/,/&,.+,�.5'%@K(+)&'+&,6'%('::",/%,83$%/,/&,.+,�.5'%@:.$(,0_+(.H/,(/,D"?/0'55/,/%,;+)'5/M:.$(,0_+(.H/,(/,D"?/0'55/,/%,;+)'5/M

]3",%'$)]3",%'$)@,#s%",+%/,?$%H&.$%/,DJ3/+)/(@,@,#s%",+%/,?$%H&.$%/,DJ3/+)/(@,)'+0"@,#/):/%&",/%,.&:'(534)/,3+:$D/,)'+0"@,#/):/%&",/%,.&:'(534)/,3+:$D/,5+$(,("63",=,0J.$),63.+D@,5+$(,("63",=,0J.$),63.+D@,)/5)"(/%&.%&,)/5)"(/%&.%&,hO,X,D+,:.)63",:'%D$.0hO,X,D+,:.)63",:'%D$.0

]3",''0'%H,]3",''0'%H,F,0"H4)/:/%&,#/):/%&"F,0"H4)/:/%&,#/):/%&"

Thé vertThé vert

Thé noirThé noir

LE THEIER : CAMELLIA SINENSISLE THEIER : CAMELLIA SINENSIS

]3"(,6'::/)6$.+7]3"(,6'::/)6$.+7 FF~.)$"&"(,*'&.%$9+/(~.)$"&"(,*'&.%$9+/(?.)G,?.)G,sinensissinensis@,@,assamicaassamica GGGG

EH/,D/(,#/+$00/(,EH/,D/(,#/+$00/(,

~.)$"&" D/( &).$&/:/%&(F~.)$"&" D/( &).$&/:/%&(F~.)$"&",D/(,&).$&/:/%&(F~.)$"&",D/(,&).$&/:/%&(F?/)&@,(/:$?/)&@,(/:$--'72D"(@,'72D"(@,.)':.&$("(,GG'72D"(@,'72D"(@,.)':.&$("(,GG

f)$H$%/,H"'H).53$9+/f)$H$%/,H"'H).53$9+/8/20.%,KB)$,i.%c.M8/20.%,KB)$,i.%c.ME((.:@,!.)P//0$%H,/&,B$cc$:,K[%D/M,E((.:@,!.)P//0$%H,/&,B$cc$:,K[%D/M,E%3+$,Kr//:+%M,/&,Ä+%%.%,K83$%/ME%3+$,Kr//:+%M,/&,Ä+%%.%,K83$%/M]3"(,D_E#)$9+/,Kr"%2.@,jo.%D.M]3"(,D_E#)$9+/,Kr"%2.@,jo.%D.M]3"(,D+,<'2/%]3"(,D+,<'2/%--f)$/%&,K]+)9+$/@,[).%Mf)$/%&,K]+)9+$/@,[).%M]3"(,D_E:")$9+/,D+,(+D,KE)H/%&$%/M]3"(,D_E:")$9+/,D+,(+D,KE)H/%&$%/M

VARIÉTÉS SELON LA TAILLE DES FEUILLES VARIÉTÉS SELON LA TAILLE DES FEUILLES

` V0'o/)2,f).%H/,>/c'/ a,KVf>M F0.,#$%/,#/+$00/,D+,*'+)H/'%,=,#/+$00/(

` f).%H/,>/c'/ a,Kf>M /(&,0.,5)/:$4)/,#/+$00/,&/%D)/,/%&$4)/:/%&,'+?/)&/ 9+$ (/ )/#'):/ = 63.9+/'+?/)&/,9+$,(/,)/#'):/,=,63.9+/,53.(/,D/,6)'$((.%6/,D+,&3"$/)G,B'%,H'y&,/(&,50+(,#')&,9+/,Vf>G,

` >/c'/ a,K>M,D"($H%/,0.,D/+7$4:/,#/+$00/,.5)4(,0/,*'+)H/'%,=,#/+$00/( F,/00/,D'%%/,+%,H'y&,:.)9+",/&,+%/,$%#+($'%,#')&/:/%&,6'0')"/

Dérivés flavaniques du thé vertDérivés flavaniques du thé vert

Flavanol

>)'&"$%/(@,.6$D/(,.:$%"(@,H0+6$D/(@,6.)'&4%/(>)'&"$%/(@,.6$D/(,.:$%"(@,H0+6$D/(@,6.)'&4%/(E6$D/,.(6')*$9+/,/&,?$&.:$%/(,D+,H)'+5/,1,E6$D/,.(6')*$9+/,/&,?$&.:$%/(,D+,H)'+5/,1,

1.(/(,7.%&3$9+/(,1.(/(,7.%&3$9+/(,5)$%6$5.0/:/%&,)/5)"(/%&"/(,5.),0.,5)$%6$5.0/:/%&,)/5)"(/%&"/(,5.),0.,6.#"$%/,KQ,6.#"$%/,KQ,-- N,X,(/0'%,?.)$"&"(,/&,#/+$00/(,6'%6/)%"/(M,d,N,X,(/0'%,?.)$"&"(,/&,#/+$00/(,6'%6/)%"/(M,d,#.$*0/(,9+.%&$&"(,D/,&3"'53200$%/,/&,&3"'*)':$%/#.$*0/(,9+.%&$&"(,D/,&3"'53200$%/,/&,&3"'*)':$%/k"&")'($D/( DJ.06''0( &/)5"%$9+/( D'%& 0J32D)'02(/ 0$*4)/k"&")'($D/( DJ.06''0( &/)5"%$9+/( D'%& 0J32D)'02(/ 0$*4)/

ASPECTS CHIMIQUES DU THE VERTASPECTS CHIMIQUES DU THE VERT

k"&")'($D/(,D .06''0(,&/)5"%$9+/(@,D'%&,0 32D)'02(/,0$*4)/,k"&")'($D/(,D .06''0(,&/)5"%$9+/(@,D'%&,0 32D)'02(/,0$*4)/,D/(,6'%(&$&+.%&(,9+$,6'%&)$*+/%&,=,0J.)x:/,D/,0J$%#+($'%D/(,6'%(&$&+.%&(,9+$,6'%&)$*+/%&,=,0J.)x:/,D/,0J$%#+($'%

8':5'("(,53"%'0$9+/(,8':5'("(,53"%'0$9+/(,KP+(9+J=,KP+(9+J=,ZO,ZO,X,X,D/,D/,0.,:.((/,(463/M,0.,:.((/,(463/M,:.$(,D'%&,0.,&/%/+),?.)$/,(/0'%,0.,?.)$"&"@,0JsH/,D/,0.,#/+$00/,:.$(,D'%&,0.,&/%/+),?.)$/,(/0'%,0.,?.)$"&"@,0JsH/,D/,0.,#/+$00/,K0/(,50+(,P/+%/(,('%&,0/(,50+(,)$63/(M,/&,0.,(.$('%,K0/(,50+(,P/+%/(,('%&,0/(,50+(,)$63/(M,/&,0.,(.$('%,KK "&"M,"&"M,FFD")$?"(,#0.?.%$9+/(,F,H.00.&/,D")$?"(,#0.?.%$9+/(,F,H.00.&/,D_"5$H.00'6.&"63'0,D_"5$H.00'6.&"63'0,K;Y8YMF,K;Y8YMF,WW--\Q,XM\Q,XM.6$D/(,53"%'0(,.6$D/(,53"%'0(,#0.?'%'CD/(,#0.?'%'CD/(,5)'.%&3'62.%$D'0(5)'.%&3'62.%$D'0(

Thomas DI PASCOLI

EGCG = gallate d'épicatécolle.

i.,9+.%&$&",D/,i.,9+.%&$&",D/,*.(/(,7.%&3$9+/(,*.(/(,7.%&3$9+/(,5)"(/%&/,"?'0+/,5/+5)"(/%&/,"?'0+/,5/+

!"?/0'55/:/%&,D/,0_.)x:/,5.),#'):.&$'%,D/,!"?/0'55/:/%&,D/,0_.)x:/,5.),#'):.&$'%,D/,5)'D+$&(,?'0.&$0(5)'D+$&(,?'0.&$0( FFD")$?"(,6"&'%$9+/(,5.),D"H).D.&$'%,D/(,6.)'&4%/(D")$?"(,6"&'%$9+/(,5.),D"H).D.&$'%,D/(,6.)'&4%/(3/7"%.0,5.),'72D.&$'%,D_.6$D/(,H).(,$%(.&+)"(3/7"%.0,5.),'72D.&$'%,D_.6$D/(,H).(,$%(.&+)"()".)).%H/:/%&,D/(,&/)54%/()".)).%H/:/%&,D/(,&/)54%/(

ASPECTS CHIMIQUES DU THE NOIRASPECTS CHIMIQUES DU THE NOIR

f72D.&$'%,D/(,f72D.&$'%,D/(,5'0253"%'0(5'0253"%'0( ?$($*0/,K63.%H/:/%&,D/,6'+0/+)M,,F?$($*0/,K63.%H/:/%&,D/,6'+0/+)M,,F

VV'):.&$'%,'):.&$'%,D/,&)'5'0'%/(,F,&3".#0.?$%/@,&3".#0.H.0$%/@,D/,&)'5'0'%/(,F,&3".#0.?$%/@,&3".#0.H.0$%/@,"5$&3".#0.H.0$%/"5$&3".#0.H.0$%/

V')&/,D$:$%+&$'%,D/,0.,&/%/+),/%,D")$?"(,#0.?.%$9+/(,K6.&"63$%/(MV')&/,D$:$%+&$'%,D/,0.,&/%/+),/%,D")$?"(,#0.?.%$9+/(,K6.&"63$%/(M

E6&$?$&"(,0$"/(,.+7,*.(/(,7.%&3$9+/(,K6.#"$%/M,.6&$?$&",(&$:+0.%&/,:'$%(,$%&/%(/,:.$(,50+(,

5)'0'%H"/,9+/,0/,6.#",K6.#"$%/,0$"/,.+7,5'0253"%'0(M,

>'0253"%'0( K%'% 5'02:")$("( D+ &3" ?/)&M F

ACTIVITES BIOLOGIQUES ACTIVITES BIOLOGIQUES DES CONSTITUANTS DU THEDES CONSTITUANTS DU THE

>'0253"%'0( K%'%,5'02:")$("(,D+,&3",?/)&M,F)"D+6&$'%,D/(,6.%6/)(,D$H/(&$#(,/&,5)"?/%&$'%,D+,,6.%6/),6'0')/6&.0,K,"&+D/(,"5$D":$'0'H$9+/(,M,.6&$?$&"(,.%&$'72D.%&/(.6&$?$&"(,.%&$*.6&")$/%%/(,K,6.)$/(@,(2(&4:/,D$H/(&$#,M

.6&$?$&",.%&$?$).0/

EVOLUTION DE LA PRODUCTION DE THÉ EVOLUTION DE LA PRODUCTION DE THÉ AU NIVEAU MONDIALAU NIVEAU MONDIAL

Thomas DI PASCOLI

Tropolone = cycle en C7.

EVOLUTION DE LA PRODUCTION DE THÉ EVOLUTION DE LA PRODUCTION DE THÉ AU NIVEAU MONDIALAU NIVEAU MONDIAL

Q,:'%'H).53$/(,=,0.,>3.):.6'5"/,#).%t.$(/,Q,:'%'H).53$/(,=,0.,>3.):.6'5"/,#).%t.$(/,THÉ VERT THÉ VERT KKCamelliae sinensis non fermentata foliaCamelliae sinensis non fermentata foliaMM

V/+$00/@,P/+%/@,%'%,#/):/%&"/@,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,V/+$00/@,P/+%/@,%'%,#/):/%&"/@,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,63.+D@,5+$(,("63"/@,D/,63.+D@,5+$(,("63"/@,D/,Camellia sinensisCamellia sinensis KiGM,r+%&e/,/&,D/,(/(,KiGM,r+%&e/,/&,D/,(/(,?.)$"&"(,6+0&$?"/(G,?.)$"&"(,6+0&$?"/(G,

DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographies analytiques du théMonographies analytiques du thé

i/,&3",?/)&,6'%&$/%&,i/,&3",?/)&,6'%&$/%&,.+,:$%$:+:,Q@O,X,D/,6.#"$%/,.+,:$%$:+:,Q@O,X,D/,6.#"$%/,6.06+0",5.),).55')&,6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/=,0.,D)'H+/,D/(("63"/

THÉ NOIR THÉ NOIR KKCamelliae sinensis fermentata foliaCamelliae sinensis fermentata foliaMM

V/+$00/,P/+%/@,#/):/%&"/@,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,V/+$00/,P/+%/@,#/):/%&"/@,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,63.+D@,5+$(,("63"/@,D/,63.+D@,5+$(,("63"/@,D/,Camellia sinensisCamellia sinensis KiGM,r+%&e/,/&,D/,(/(,KiGM,r+%&e/,/&,D/,(/(,?.)$"&"(,6+0&$?"/(G,?.)$"&"(,6+0&$?"/(G,

i/,&3",%'$),6'%&$/%&,i/,&3",%'$),6'%&$/%&,.+,:$%$:+:,Q@W,X,6/%&,D/,6.#"$%/,.+,:$%$:+:,Q@W,X,6/%&,D/,6.#"$%/,6.06+0",5.),6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/G,).55')&,=,0.,D)'H+/,D/(("63"/G,

;7.:/%,:$6)'(6'5$9+/,;7.:/%,:$6)'(6'5$9+/,FF


.G,,:.60/(,D_'7.0.&/,D/,8.,/&,5'$0(,&/6&/+)(,+%$6/00+0.$)/(,=,5.)'$(,"5.$((/,/&,/7&)":$&",6'%$9+/.G,,:.60/(,D_'7.0.&/,D/,8.,/&,5'$0(,&/6&/+)(,+%$6/00+0.$)/(,=,5.)'$(,"5.$((/,/&,/7&)":$&",6'%$9+/*G,,(60")$&/(*G,,(60")$&/(6G,,"5$D/):/,(+5")$/+),%'%,(&':.&$#4)/6G,,"5$D/):/,(+5")$/+),%'%,(&':.&$#4)/DG,,"5$D/):/,$%#")$/+),(&':.&$#4)/,.?/6,(&':.&/(,/%&'+)"(,5.),Z,'+,N,6/00+0/(,.%%/7/(DG,,"5$D/):/,$%#")$/+),(&':.&$#4)/,.?/6,(&':.&/(,/%&'+)"(,5.),Z,'+,N,6/00+0/(,.%%/7/(

;7.:/%,/%,63)':.&'H).53$/,(+),6'+63/,,;7.:/%,/%,63)':.&'H).53$/,(+),6'+63/,,:$%6/,F:$%6/,F~$(+.0$(.&$'%,D/,0.,6.#"$%/,/&,D/,0.,&3"'*)':$%/,~$(+.0$(.&$'%,D/,0.,6.#"$%/,/&,D/,0.,&3"'*)':$%/,/%,U~/%,U~K,QWN,%:,M,/&,5.),5+0?")$(.&$'%,D/,K,QWN,%:,M,/&,5.),5+0?")$(.&$'%,D/,)".6&$#,$'D')".6&$#,$'D'--$'D+)",$'D+)",


K M 5 5K M 5 5/%,5)"(/%6/,D_+%,&":'$%,D/,6.#"$%//%,5)"(/%6/,D_+%,&":'$%,D/,6.#"$%/

>/)&/,=,0.,D/(($6.&$'%,F,>/)&/,=,0.,D/(($6.&$'%,F, h,Xh,X

8/%D)/(,&'&.0/(,F,8/%D)/(,&'&.0/(,F, b,Xb,X

!'(.H/,D/,0.,6.#"$%/,5.),8ik>!'(.H/,D/,0.,6.#"$%/,5.),8ik>

LE MATÉ : Ilex paraguariensisLE MATÉ : Ilex paraguariensis

LE MATÉ : Ilex paraguariensisLE MATÉ : Ilex paraguariensis

FORMES COMMERCIALES DU MATÉFORMES COMMERCIALES DU MATÉ

CONSTITUANTS ACTIFS PRINCIPAUX DU MATECONSTITUANTS ACTIFS PRINCIPAUX DU MATE

MATÉ VERT MATÉ VERT KKIlex paraguarensisIlex paraguarensisM,,>3G,V).%t.$(/,\OM,,>3G,V).%t.$(/,\O4:/4:/ "D$&$'%"D$&$'%

i.,5.)&$/,+&$0$(",D+,:.&",?/)&,/(&,6'%(&$&+"/,5.),0.,#/+$00/,D/,i.,5.)&$/,+&$0$(",D+,:.&",?/)&,/(&,6'%(&$&+"/,5.),0.,#/+$00/,D/,Ilex Ilex paraguarensis paraguarensis B&G,k$0G,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,B&G,k$0G,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,63.+D@,5+$(,$%6$("/,G,i/,:.&",?/)&,6'%&$/%&,63.+D@,5+$(,$%6$("/,G,i/,:.&",?/)&,6'%&$/%&,.+,:$%$:+:,\@O,X,.+,:$%$:+:,\@O,X,D/,6.#"$%/D/,6.#"$%/ 6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/i/ :.&" (/ 5)"(/%&/ /% :')6/.+7 $))"H+0$/)( .%H+0/+7i/ :.&" (/ 5)"(/%&/ /% :')6/.+7 $))"H+0$/)( .%H+0/+7

DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographie analytique du matéMonographie analytique du maté

i/,:.&",(/,5)"(/%&/,/%,:')6/.+7,$))"H+0$/)(@,.%H+0/+7@,i/,:.&",(/,5)"(/%&/,/%,:')6/.+7,$))"H+0$/)(@,.%H+0/+7@,H0.*)/(@,?/)&,P.+%s&)/@,/&,:/(+).%&,D.%(,0/+),50+(,H).%D/,H0.*)/(@,?/)&,P.+%s&)/@,/&,:/(+).%&,D.%(,0/+),50+(,H).%D/,D$:/%($'%,D/,Q::,=,N::GD$:/%($'%,D/,Q::,=,N::G;7.:/%,/%,63)':.&'H).53$/,(+),6'+63/,:$%6/,F;7.:/%,/%,63)':.&'H).53$/,(+),6'+63/,:$%6/,F-- ?$(+.0$(.&$'%?$(+.0$(.&$'% D/D/ 0.0. 6.#"$%/6.#"$%/ /&/& D/D/ 0.0. &3"'*)':$%/&3"'*)':$%/ /%/% U~U~ KK QWNQWN %:%: MM-- 5+0?")$(.&$'%5+0?")$(.&$'% D/D/ )".6&$#)".6&$# $'D'$'D'--$'D+)"$'D+)" /%/% 5)"(/%6/5)"(/%6/ D/D/ &":'$%&":'$% 6.#"$%/6.#"$%/

>/)&/,=,0.,D/(($6.&$'%,F,,h,X>/)&/,=,0.,D/(($6.&$'%,F,,h,X8/%D)/(,&'&.0/(,F,,h,X8/%D)/(,&'&.0/(,F,,h,X!'(.H/,D/,0.,6.#"$%/,5.),8ik>!'(.H/,D/,0.,6.#"$%/,5.),8ik>

DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEAnalyse microscopique du matéAnalyse microscopique du maté

LE GUARANA : Paullinia cupana LE GUARANA : Paullinia cupana KunthKunthvar. var. sorbilissorbilis

E)*+(&/ D/,0.,#.:$00/,D/(,,B.5$%D.6"/(,')$H$%.$)/,D/,0.,)"H$'%,.:.e'%$/%%/

i/(,#)+$&(,F,*.$/(,)'+H/,-').%H"/( 6'%&/%.%& Z H).$%/(').%H"/(,6'%&/%.%&,,Z,H).$%/(,

i.,D)'H+/,F,.:.%D/,D/,0.,H).$%/ '*&/%+/,.5)4(,5.((.H/,(+),+%/,('+)6/,D/,63.0/+)

U(.H/,.%6$/%,5.),0/(,6'::+%.+&"(,.:.e'%$/%%/(,6'::/,.%&$:.0.)$9+/@,(&$:+0.%&/&,` .%&$-#.$: a

1.(/(,7.%&3$9+/(,1.(/(,7.%&3$9+/(,5)$%6$5.0/:/%&,)/5)"(/%&"/(,5.)5)$%6$5.0/:/%&,)/5)"(/%&"/(,5.)0.,6.#"$%/,K,Z,0.,6.#"$%/,K,Z,-- S,X,M,S,X,M,D/,#.$*0/(,9+.%&$&"(,D/,&3"'53200$%/,/&,&3"'*)':$%/D/,#.$*0/(,9+.%&$&"(,D/,&3"'53200$%/,/&,&3"'*)':$%/

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COMPOSES ACTIFS DU GUARANACOMPOSES ACTIFS DU GUARANA

.6$D/,6.&"63+&.%%$9+/.6$D/,6.&"63+&.%%$9+/

>)"(/%6/,D/,(.5'%$%/(,K+(.H/,6'::/,5$(6$6$D/M>)"(/%6/,D/,(.5'%$%/(,K+(.H/,6'::/,5$(6$6$D/M]).6/(,D/,?.%$00$%/]).6/(,D/,?.%$00$%/

U(.H/(,5)$%6$5.+7,6'::/,FU(.H/(,5)$%6$5.+7,6'::/,FB&$:+0.%&,532($9+/,/&,$%&/00/6&+/0B&$:+0.%&,532($9+/,/&,$%&/00/6&+/08'+5/8'+5/--#.$:,`#.$:,` %.&+)/0%.&+)/0 a,K)$(9+/(,5'+),0.,(.%&"Ma,K)$(9+/(,5'+),0.,(.%&"M

Thomas DI PASCOLI

Pas d'effet sur le parasite mais effet stimulante qui procure l'énergie pour lutter contre la maladie.

FORMES COMMERCIALES DU GUARANAFORMES COMMERCIALES DU GUARANA

Pharmacopée française : 2 monographies (graine et pâte) Pharmacopée française : 2 monographies (graine et pâte)

YjE[n;,YjE[n;,(Paulliniae sorbilis semen)(Paulliniae sorbilis semen)Y).$%/,('+:$(/,=,+%/,).5$D/,D/(($6.&$'%,=,63.+D,Y).$%/,('+:$(/,=,+%/,).5$D/,D/(($6.&$'%,=,63.+D,8 &$ & $ $ Z W X D #"$ 0 0" &8 &$ & $ $ Z W X D #"$ 0 0" &

DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographies analytiques du guaranaMonographies analytiques du guarana

8'%&$/%&,.+,:$%$:+:,Z@W,X,D/,6.#"$%/,6.06+0"/,5.),).55')&,8'%&$/%&,.+,:$%$:+:,Z@W,X,D/,6.#"$%/,6.06+0"/,5.),).55')&,=,0.,D)'H+/,D/(("63"/=,0.,D)'H+/,D/(("63"/

>E];,>E];,(Paulliniae sorbilis contriti siccatique nuclei)(Paulliniae sorbilis contriti siccatique nuclei)>s&/,("63"/,'*&/%+/,5.),"6).(/:/%&,D/,0_.:.%D/@,('+:$(/,>s&/,("63"/,'*&/%+/,5.),"6).(/:/%&,D/,0_.:.%D/@,('+:$(/,=,+%/,).5$D/,D/(($6.&$'%,=,63.+D,/&,3+:$D$#$"/=,+%/,).5$D/,D/(($6.&$'%,=,63.+D,/&,3+:$D$#$"/

i.,5s&/,D/,H+.).%.,6'%&$/%&,.+,:$%$:+:,Z@O,X,D/,6.#"$%/,6.06+0"/,i.,5s&/,D/,H+.).%.,6'%&$/%&,.+,:$%$:+:,Z@O,X,D/,6.#"$%/,6.06+0"/,5.),).55')&,=,0.,D)'H+/,D/(("63"/5.),).55')&,=,0.,D)'H+/,D/(("63"/

DOMAINE PHARMACEUTIQUEDOMAINE PHARMACEUTIQUEMonographies analytiques du guaranaMonographies analytiques du guarana

[D/%&$&",/%,88<,F,[D/%&$&",/%,88<,F,?$(+.0$(.&$'%,/%,U~,?$(+.0$(.&$'%,/%,U~,5+0?")$(.&$'%,D/,)".6&$#,$'D'5+0?")$(.&$'%,D/,)".6&$#,$'D'--$'D+)",/%,5)"(/%6/,$'D+)",/%,5)"(/%6/,D_+%,&":'$%,D/,6.#"$%/D_+%,&":'$%,D/,6.#"$%/

>/)&/,=,0.,D/(($6.&$'%,F,>/)&/,=,0.,D/(($6.&$'%,F,\O,X,KH).$%/,/&,5s&/M\O,X,KH).$%/,/&,5s&/M

8/%D)/(,&'&.0/(,F,,8/%D)/(,&'&.0/(,F,, N,X,5'+),0.,H).$%/N,X,5'+),0.,H).$%/S,X,5'+),0.,5s&/S,X,5'+),0.,5s&/

!'(.H/,D/,0.,6.#"$%/,5.),8ik>!'(.H/,D/,0.,6.#"$%/,5.),8ik>

LE CACAOTheobroma cacao L.

8.6.'2/),F,8.6.'2/),F,.)*)/,&)'5$6.0,.)*)/,&)'5$6.0,')$H$%.$)/,')$H$%.$)/,D+,</7$9+/,D/,0.,#.:$00/,D/(,D+,</7$9+/,D/,0.,#.:$00/,D/(,B&/)6+0$.6"/(B&/)6+0$.6"/(V)+$&,p,V)+$&,p,6.*'((/6.*'((/@,\W,@,\W,-- QO6:,D/,0'%H@,QO6:,D/,0'%H@,5'$D(,5'$D(, NOOHNOOH>'+((/%&,D$)/6&/:/%&,(+),0/(,>'+((/%&,D$)/6&/:/%&,(+),0/(,*).%63/(,:.g&)/((/(,'+,0/,&)'%6,*).%63/(,:.g&)/((/(,'+,0/,&)'%6,D/,0_.)*)/D/,0_.)*)/Ee&49+/(,Ee&49+/(, *)/+?.H/,.:/),/&,"5$6"@,*)/+?.H/,.:/),/&,"5$6"@,K,K,tchocolatl tchocolatl M@,)"(/)?",=,0_/:5/)/+)@,M@,)"(/)?",=,0_/:5/)/+)@,.+7,%'*0/(,/&,.+7,H+/))$/)(,.+7,%'*0/(,/&,.+7,H+/))$/)(,

LE CACAOTheobroma cacao L.

[%&)'D+6&$'%,/%,;+)'5/,5.),8')&"([%&)'D+6&$'%,/%,;+)'5/,5.),8')&"(;%H'+/:/%&,5'+),0.,*'$(('%,/%,;%H'+/:/%&,5'+),0.,*'$(('%,/%,;+)'5/,=,5.)&$),D+,}~[[;+)'5/,=,5.)&$),D+,}~[[4:/4:/ ($460/($460/

\hNb,F,%.$((.%6/,D+,63'6'0.&,`\hNb,F,%.$((.%6/,D+,63'6'0.&,` /%,/%,50.9+/50.9+/ a,=,5.)&$),D_+%,:"0.%H/,D/,a,=,5.)&$),D_+%,:"0.%H/,D/,

LE CACAOCultures dans le monde

Thomas DI PASCOLI

Les fruits poussent sur le tronc.

LE CACAOCulture et variété

A+.&)/,?.)$"&"(,5)$%6$5.0/,D/,6.6.'A+.&)/,?.)$"&"(,5)$%6$5.0/,D/,6.6.'i/,i/,#').(&/)'#').(&/)' KRW,X,D/,0.,5)'D+6&$'%,:'%D$.0/M,KRW,X,D/,0.,5)'D+6&$'%,:'%D$.0/M,')$H$%.$)/,DJE:.e'%$/,:.$(,5)$%6$5.0/:/%&,')$H$%.$)/,DJE:.e'%$/,:.$(,5)$%6$5.0/:/%&,6+0&$?",/%,E#)$9+/@,1)"($0,/&,Å9+.&/+),6+0&$?",/%,E#)$9+/@,1)"($0,/&,Å9+.&/+),)+(&$9+/,K)+(&$9+/,K22MMi/i/ 6)$'00'6)$'00' F 6+0&$?" /% E:")$9+/ 0.&$%/F 6+0&$?" /% E:")$9+/ 0.&$%/i/,i/,6)$'00'6)$'00' F,6+0&$?",/%,E:")$9+/,0.&$%/,F,6+0&$?",/%,E:")$9+/,0.&$%/,K8.).C*/(@,E%&$00/(@,</7$9+/@,~/%/e+/0.@,K8.).C*/(@,E%&$00/(@,</7$9+/@,~/%/e+/0.@,8'0':*$/M,8'0':*$/M, 6.6.',6.6.',#$%,/&,.)':.&$9+/#$%,/&,.)':.&$9+/i/,i/,&)$%$&.)$'&)$%$&.)$'@,$((+,D+,6)'$(/:/%&,D/(,D/+7,@,$((+,D+,6)'$(/:/%&,D/(,D/+7,5)"6"D/%&(,K\W,X,D/,0.,5)'D+6&$'%,:'%D$.0/M,5)"6"D/%&(,K\W,X,D/,0.,5)'D+6&$'%,:'%D$.0/M,/(546/,)"($(&.%&/,5)'D+$(.%&,+%,6.6.',#$%,/(546/,)"($(&.%&/,5)'D+$(.%&,+%,6.6.',#$%,

KK1 et 31 et 3MMi/,i/,%.6$'%.0%.6$'%.0 K6+0&+)/,.%D$%/M,K6+0&+)/,.%D$%/M, 6.6.',&)4(,#$%,6.6.',&)4(,#$%,:.$(,/(546/,#).H$0/,F,5)'D+6&$'%,&)4(,#.$*0/:.$(,/(546/,#).H$0/,F,5)'D+6&$'%,&)4(,#.$*0/

LE CACAOÉconomie du cacao

>)'D+6&$'%,/%,&'%%/(,D/,#4?/,D/,6.6.',K63$##)/(,VEf,QOOSM

LE CACAODu traitement post-récolte au cacao marchand

>0+5.)&,D/(,5.2(,5)'D+6&/+)(,F,>0+5.)&,D/(,5.2(,5)'D+6&/+)(,F,)"6'0&/,D/+7,#'$(,5.),.%)"6'0&/,D/+7,#'$(,5.),.%

;6.*'((.H/,F,'5").&$'%,:.%+/00/,;6.*'((.H/,F,'5").&$'%,:.%+/00/,%"6/(($&.%&,+%/,:.$%%"6/(($&.%&,+%/,:.$%--D_'/+?)/,D_'/+?)/,$:5')&.%&/$:5')&.%&/$:5')&.%&/$:5')&.%&/

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LE CACAODu cacao marchand au produit semi-fini

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CACAO ET CHOCOLATAspects nutritionnels

CACAO ET CHOCOLATLe cacao contient-il de la caféine ?

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Fèves de cacao : 1,1 – 4,3 % Chocolat au lait : 0,1 – 0,2 %

Cacao en poudre : 0,5 – 2,6 % Chocolat noir : 0,4 – 1,6 %

CACAO ET CHOCOLATPolyphénols du cacao

CACAO ET CHOCOLATAspects règlementaires (décret n°76-692)

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CACAO ET CHOCOLATContrôle de la qualité finale

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COMPARAISON DANS LA TENEUR EN CAFEINE COMPARAISON DANS LA TENEUR EN CAFEINE DE DIVERSES BOISSONSDE DIVERSES BOISSONS

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PAVOT, OPIUM ET MORPHINEPAVOT, OPIUM ET MORPHINE

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[D/%&$&" F

OPIUM

[D/%&$&",F,:$6)'H).53$/,KrfkM,F,

H).%+0.&$'%(,*)+%/(@,#$0.:/%&(@,5'00/%

)".6&$'%(,63$:$9+/(,F,'5$+:,d,kQf, #$0&).&,,,,,,,,,d,80ZV/ )'+H/,K,.6$D/,:"6'%$9+/,M,d,80k, D$(5.)$&$'%

88<,K,.06.0'CD/(,&":'$%(,M,F,)"?"0.&$'%,.+,$'D'*$(:+&3.&/,r,K!).H/%D')##M

MATIÈRES PREMIÈRES ISSUES DE L’OPIUM : MATIÈRES PREMIÈRES ISSUES DE L’OPIUM : PAILLE DE PAVOTPAILLE DE PAVOT

8+0&+)/,.%6$/%%/,/%,;+)'5/,8+0&+)/,.%6$/%%/,/%,;+)'5/, H).$%/(,K5.?'&,,H).$%/(,K5.?'&,,'/$00/&&/M'/$00/&&/M

E:"0$').&$'%,?.)$"&"(,/&,5).&$9+/(,6+0&+).0/,E:"0$').&$'%,?.)$"&"(,/&,5).&$9+/(,6+0&+).0/,5)'D+6&$'% D$)/6&/ D/(5)'D+6&$'% D$)/6&/ D/( .06.0'CD/(.06.0'CD/( K5.( D/ 5)'D+6&$'%K5.( D/ 5)'D+6&$'%5)'D+6&$'%,D$)/6&/,D/(,5)'D+6&$'%,D$)/6&/,D/(,.06.0'CD/(,.06.0'CD/(,K5.(,D/,5)'D+6&$'%K5.(,D/,5)'D+6&$'%D_'5$+:MD_'5$+:M

!/+7,5'(($*$0$&"(,F!/+7,5'(($*$0$&"(,F

B+5/)#$6$/,K,V).%6/,M,F,ROOO,3.,B+5/)#$6$/,K,V).%6/,M,F,ROOO,3., RORO &'%%/(,&'%%/(,:')53$%/:')53$%/

EXTRACTION DE LA MORPHINEEXTRACTION DE LA MORPHINE

E,5.)&$),D/,0_'5$+:,Z,X,'5$+:, +(.H/,D$)/6&,/%,H.0"%$9+/,bR,X,K0$6$&/M, (/)&,=,0_/7&).6&$'%,D/,0.,:')53$%/,>)'6"D" &).D$&$'%%/0 F>)'6"D",&).D$&$'%%/0,F<"&3'D/,:'D$#$"/,D/,Y)/H')2,Ñ,j'*/)&('%@,\b4:/ ($460/G,!"50.6/:/%&,=,5.)&$),D/,0.,#'):/,%.&+)/00/, :"6'%.&/,D/:')53$%/,F

Morphine


+ eau ( 25 °C ) + Ca(OH)2

Opium

Concentration

Morphinate de Ca en solution

Méconate de Ca

Ebullition + NH4Cl

Morphine en refroidissant


A partir de la paille de pavot A partir de la paille de pavot ;7&).6&$'%,;7&).6&$'%,('0$D/('0$D/--0$9+$D/,0$9+$D/, 6'%6/%&)",D/,5.$00/,D/,5.?'&,KH).%+0"(M,6'%6/%&)",D/,5.$00/,D/,5.?'&,KH).%+0"(M,d,/.+,.6$D/,d,/.+,.6$D/, .06.0'CD/(,(/0(,.06.0'CD/(,(/0(, d,*.(/,#.$*0/,d,*.(/,#.$*0/, :')53$%/,:')53$%/,("0/6&$?/:/%&,("0/6&$?/:/%&,

>+)$#$6.&$'%,5.),)"($%/(,"63.%H/+(/(,DJ$'%(,'+,5)"6$5$&.&$'%(,>+)$#$6.&$'%,5.),)"($%/(,"63.%H/+(/(,DJ$'%(,'+,5)"6$5$&.&$'%(,("0/6&$?/(("0/6&$?/(

;((/%&$/0,5)'D+6&$'%,:')53$%/,;((/%&$/0,5)'D+6&$'%,:')53$%/, 5)"5.).&$'%,D/,0.,5)"5.).&$'%,D/,0.,6'D"$%/,/&,D/,0.,6'D"&320$%/6'D"$%/,/&,D/,0.,6'D"&320$%/

QOOO,F,6'%('::.&$'%,:'%D$.0/,:')53$%/, ,QQ,&'%%/(,QOOO,F,6'%('::.&$'%,:'%D$.0/,:')53$%/, ,QQ,&'%%/(,K6'D"$%/, ,QOO,&'%%/(,p,RWX,D/,&'+(,0/(,'5$.6"/(MK6'D"$%/, ,QOO,&'%%/(,p,RWX,D/,&'+(,0/(,'5$.6"/(M

ASPECTS STRUCTURAUXASPECTS STRUCTURAUX

Morphine : Morphine : .06.0'CD/,:.P')$&.$)/,D/,0J'5$+:,F.06.0'CD/,:.P')$&.$)/,D/,0J'5$+:,FK\O,=,\Q,XMK\O,=,\Q,XMW,6/%&)/(,.((2:"&)$9+/(,F,W,6/%&)/(,.((2:"&)$9+/(,F,(2%&34(/,&'&.0/,6':50/7/(2%&34(/,&'&.0/,6':50/7/

;%.%&$':4)/,0"?'H$)/,%.&+)/0,.6&$#,;%.%&$':4)/,0"?'H$)/,%.&+)/0,.6&$#,>3"%'0,/%,Z,F,('0+*$0$&",D.%(,('0G,>3"%'0,/%,Z,F,('0+*$0$&",D.%(,('0G,.06.0$%/(,K:')53$%.&/M,/&,5)'5)$"&"(,.06.0$%/(,K:')53$%.&/M,/&,5)'5)$"&"(,)"D+6&)$6/()"D+6&)$6/(830')32D).&/,F,6)$(&.00$(/,.?/6,Z,k830')32D).&/,F,6)$(&.00$(/,.?/6,Z,kQQff

Codéine : Codéine : f8kf8kZZ /%,5'($&$'%,Z,/%,5'($&$'%,Z,5.(,D/,#'%6&$'%,53"%'05.(,D/,#'%6&$'%,53"%'0

PROPRIETES PHARMACOLOGIQUESPROPRIETES PHARMACOLOGIQUES

;##/&(,D/,0.,:')53$%/,(+),0/,Bn8,F;##/&(,D/,0.,:')53$%/,(+),0/,Bn8,FV$7.&$'%,(&")"'(5"6$#$9+/,/&,)"?/)($*0/,(+),)"6/5&/+)(,(5"6$#$9+/(V$7.&$'%,(&")"'(5"6$#$9+/,/&,)"?/)($*0/,(+),)"6/5&/+)(,(5"6$#$9+/(;##/&,.%.0H"($9+/,F;##/&,.%.0H"($9+/,FÖ,,Ö,, (/+$0,5/)6/5&$'%,D'+0/+)@,(/+$0,5/)6/5&$'%,D'+0/+)@, 5/)6/5&$'%,%'6$6/5&$?/5/)6/5&$'%,%'6$6/5&$?/Ö,,Ö,, (+P/&,('+##).%&,/&,(+P/&,%'):.0(+P/&,('+##).%&,/&,(+P/&,%'):.0;##/&,)/(5$).&'$)/,F;##/&,)/(5$).&'$)/,F55Ö,,Ö,, 6/%&)/(,*+0*.$)/(@,*).D25%"/@,$))"H+0.)$&",)2&3:/6/%&)/(,*+0*.$)/(@,*).D25%"/@,$))"H+0.)$&",)2&3:/E+&)/(,/##/&(,6/%&).+7,FE+&)/(,/##/&(,6/%&).+7,FÖ,,Ö,, 6/%&)/,&'+7@,6/%&)/,&'+7@, 325'532(/@,:2'($(325'532(/@,:2'($(!"5/%D.%6/,F!"5/%D.%6/,FÖ,,;##/&,5(263'D2(0/5&$9+/,F,/+53')$/,/&,*$/%Ö,,;##/&,5(263'D2(0/5&$9+/,F,/+53')$/,/&,*$/%--^&)/^&)/Ö,,E))^&,*)+&.0,Ö,,E))^&,*)+&.0, (2%D)':/,D/,:.%9+/,F,)3$%')3"/@,(+/+)(@,.H$&.&$'%@,(2%D)':/,D/,:.%9+/,F,)3$%')3"/@,(+/+)(@,.H$&.&$'%@,

:2D)$.(/@,.0H$/(,:2D)$.(/@,.0H$/(, D"5/%D.%6/,532($9+/D"5/%D.%6/,532($9+/

;##/&(,5")$53")$9+/(;##/&(,5")$53")$9+/( :: 6'%(&$5.&$'%@,)"&/%&$'%,+)$%.$)/6'%(&$5.&$'%@,)"&/%&$'%,+)$%.$)/

QUINQUINA ET QUININEQUINQUINA ET QUININE

\G [%&)'D+6&$'%,/&,.(5/6&(,3$(&')$9+/(QG !"#$%$&$'%ZG i/(,D$##")/%&/(,/(546/(,D/,9+$%9+$%.NG >.)&$/(,+&$0$("/(

B'+)6/(8':5'($&$'%,63$:$9+/

WG <'%'H).53$/,9+$%9+$%.,)'+H/8.).6&4)/(,')H.%'0/5&$9+/(,/&,:$6)'(6'5$9+/([D/%&$#$6.&$'%,/&,/((.$(!'(.H/

SG, ;:50'$(

INTRODUCTION ET DEFINITIONINTRODUCTION ET DEFINITIONU&$0$(.&$'%,&).D$&$'%/00/,.%6$/%%/,6'::/,#"*)$#+H/,.+,>")'+U&$0$(.&$'%,&).D$&$'%/00/,.%6$/%%/,6'::/,#"*)$#+H/,.+,>")'+

[%&)'D+$&/,/%,;+)'5/,K,P"(+$&/(,M,.+,}~[[[%&)'D+$&/,/%,;+)'5/,K,P"(+$&/(,M,.+,}~[[4:/4:/ ($460/,($460/,H).%D,(+664(,6'::/,#"*)$#+H/@,.%&$:.0.)$9+/H).%D,(+664(,6'::/,#"*)$#+H/@,.%&$:.0.)$9+/

Y/%)/,Y/%)/,CinchonaCinchona K,j+*$.6"/(,M,6)"/,5.),i$%%",/%,\RNQ,K,j+*$.6"/(,M,6)"/,5.),i$%%",/%,\RNQ,=,=,5.)&$),5.)&$),D_"63.%&$00'%(,D_"63.%&$00'%(,5)'?/%.%&,D+,>")'+5)'?/%.%&,D+,>")'+55 55

[('0/:/%&,D/,0.,[('0/:/%&,D/,0.,9+$%$%/9+$%$%/ F,>/00/&$/),/&,8.?/%&'+,K\hQOMF,>/00/&$/),/&,8.?/%&'+,K\hQOM

!"#$%$&$'%,D/,0.,>3.):.6'5"/,/+)'5"/%%/,!"#$%$&$'%,D/,0.,>3.):.6'5"/,/+)'5"/%%/,FFA+$%9+$%.,)'+H/,F,"6')6/,D/(("63"/,D/,A+$%9+$%.,)'+H/,F,"6')6/,D/(("63"/,D/,C. pubescensC. pubescens ~.30,~.30,KKC. succirubraC. succirubra >.?'%M,'+,D/,(/(,?.)$"&"(,'+,32*)$D/(>.?'%M,'+,D/,(/(,?.)$"&"(,'+,32*)$D/(

B/+0/,(5G,B/+0/,(5G, :'%'H).53$/,53.):.6/+&$9+/:'%'H).53$/,53.):.6/+&$9+/

E+&)/(,(55G,,E+&)/(,(55G,, (5(5G,/7&).6&$'%,9+$%$%/,F,G,/7&).6&$'%,9+$%$%/,F,C. ledgerianaC. ledgeriana(5(5G,0$9+')$(&/)$/,F,G,0$9+')$(&/)$/,F,C. officinalisC. officinalis

LES ESPECESLES ESPECESY/%)/,Cinchona F,9+.).%&.$%/,DJ/(546/(,D_.)*)/(

f)$H$%/,F,,8')D$004)/,.%D$%/,K8'0':*$/, >")'+M\WOO,- ZOOO:@,#')&/,50+?$'($&"#/+$00/(,'55'("/(@,#0/+)(,*0.%63/(,'+,)'("/(

;7$(&/%6/,32*)$D/( F .%6$/%%/&",D/(,6+0&+)/(,/&,("0/6&$'%2

!$(&$%6&$'%(,/%&)/,FAG,)'+H/,,KC. pubescens ~.30@,(2%G,C. succirubra >.?'%M,F,

/(546/,'##$6$%.0/,K')$H$%/,(5G,(.+?.H/,p,;9+.&/+)M

AG,H)$(,,KC. officinalis iGM,F,D$(&)$*+"/,8'0':*$/ .+,>")'+/(546/,.)':.&$9+/,F,+(.H/,/%,0$9+')$(&/)$/

AG,P.+%/,,KC. calisaya q/DD/00MF,D$(&)$*+"/,8'0':*$/ =,0.,1'0$?$/

Cinchona ledgeriana F,,/7&).6&$'%,D/,0.,9+$%$%/

A+$%9+$%.,)'+H/A+$%9+$%.,)'+H/

Cinchona Cinchona succirubrasuccirubra

A+$%9+$%.,H)$(A+$%9+$%.,H)$(

Cinchona Cinchona officinaofficina A+$%9+$%.,P.+%/A+$%9+$%.,P.+%/

Cinchona Cinchona calisayacalisaya A+$%9+$%.,0/DH/)$.%.A+$%9+$%.,0/DH/)$.%.

Cinchona Cinchona ledgerianaledgeriana

Thomas DI PASCOLI

Le "officinalis" n'est pas médicinal.

LA DROGUE : ÉCORCELA DROGUE : ÉCORCE

B'+)6/(,F,,B'+)6/(,F,,A+$%9+$%.(,D/,6+0&+)/,A+$%9+$%.(,D/,6+0&+)/,

E#)$9+/,'66$D/%&.0/,/&,')$/%&.0/E#)$9+/,'66$D/%&.0/,/&,')$/%&.0/

E:")$9+/,0.&$%/,E:")$9+/,0.&$%/, Å6')6/ D/ 9+$%9+$%. )'+H/Å6')6/ D/ 9+$%9+$%. )'+H/" 9+/ . /" 9+/ . /K,>")'+@,1'0$?$/@,;9+.&/+),MK,>")'+@,1'0$?$/@,;9+.&/+),M

f*&/%&$'%,F,f*&/%&$'%,F,1.&&.H/,/&,"6')t.H/,D/(,&)'%6(,1.&&.H/,/&,"6')t.H/,D/(,&)'%6(,/&,D/(,*).%63/(/&,D/(,*).%63/(

Å6')6/,D/,9+$%9+$%.,)'+H/Å6')6/,D/,9+$%9+$%.,)'+H/

Å6')6/,D/,Å6')6/,D/,Cinchona ledgerianaCinchona ledgeriana

COMPOSITION CHIMIQUECOMPOSITION CHIMIQUE>'0253"%'0(>'0253"%'0( F,#0.?.%F,#0.?.%--ZZ--'0(,(+*(&$&+"(,5.),.6$D/,6.#"$9+/'0(,(+*(&$&+"(,5.),.6$D/,6.#"$9+/

5)'.%&3'62.%$D'0(,D$:4)/(,/&,&)$:4)/(5)'.%&3'62.%$D'0(,D$:4)/(,/&,&)$:4)/(

E6$D/(,')H.%$9+/(,5.)&$6+0$/)(,E6$D/(,')H.%$9+/(,5.)&$6+0$/)(,F,.6$D/,9+$%$9+/,F,.6$D/,9+$%$9+/,

B.5'%'($D/(B.5'%'($D/( =,H"%$%/,&)$&/)5"%$9+/,D$6.)*'720$9+/=,H"%$%/,&)$&/)5"%$9+/,D$6.)*'720$9+/

]).6/(,DJ3+$0/,/((/%&$/00/]).6/(,DJ3+$0/,/((/%&$/00/

i.,&/%/+),D/(,i.,&/%/+),D/(,.06.0'CD/(.06.0'CD/( ?.)$/,(/0'%,0_/(546/,F?.)$/,(/0'%,0_/(546/,F

E06.0'CD/(,&'&.+7,E06.0'CD/(,&'&.+7,XX

A+$%$%/,XA+$%$%/,X

A+$%9+$%.,)'+H/A+$%9+$%.,)'+H/ N@W,N@W,ÉÉ h@Wh@W \,\,ÉÉ ZZ

A+$%9+$%.,H)$(A+$%9+$%.,H)$( W,W,ÉÉ hh Q,Q,ÉÉ R@WR@W

A+$%9+$%.,P.+%/A+$%9+$%.,P.+%/ Z,Z,ÉÉ RR O,O,ÉÉ NN

A+$%9+$%.,0/DH/)$.%.A+$%9+$%.,0/DH/)$.%. S,S,ÉÉ \N\N Z,Z,ÉÉ \Z\Z

STRUCTURE DES ALCALOIDESSTRUCTURE DES ALCALOIDES

E06.0'CD/(,:.P')$&.$)/(,D.%(,0_"6')6/,F,E06.0'CD/(,:.P')$&.$)/(,D.%(,0_"6')6/,F,

9+$%$%/,/&,9+$%$D$%/,9+$%$%/,/&,9+$%$D$%/,K,(&")"'K,(&")"'--$(':4)/(M,F,$(':4)/(M,F,9+$%'0"$%/,)/0$"/,=,%'2.+,*$6260$9+/,9+$%+60$D$9+/9+$%'0"$%/,)/0$"/,=,%'2.+,*$6260$9+/,9+$%+60$D$9+/

6$%63'%$D$%/,/&,6$%63'%$%/,6$%63'%$D$%/,/&,6$%63'%$%/,F,3':'0'H+/(,F,3':'0'H+/(,D":"&3'720"(,/%,8D":"&3'720"(,/%,8--SSll

E06.0'CD/(,:$%')$&.$)/(,D/,%.&+)/,$%D'0$9+/,K,6$%63'%.:$%/,M,:.P')$&.$)/(,D.%(,0/(,#/+$00/(

Thomas DI PASCOLI

+Asie (inde, thailande, vietnam, laos cambodge).

MONOGRAPHIE QUINQUINA ROUGEMONOGRAPHIE QUINQUINA ROUGE

8.).6&4)/(,')H.%'0/5&$9+/(,FV).H:/%&(,D_"6')6/,D/,*).%63/,/&,&)'%6,- B+)#.6/,/7&/)%/,H)$(-*)+%@,#$((+)"/,&).%(?G@,($00'%"/,0'%H$&+D$%.0/:/%&

- B+)#.6/,$%&/)%/,F,*)+%-)'+H/,#'%6"- B.?/+),&)4(,.:4)/

8.).6&4)/(,:.6)'(6'5$9+/(,F- V$*)/(,P.+%/(,=,5.)'$(,"5.$((/(@,(&)$"/(,/&,6.%.0$6+0"/(

- [D$'*0.(&/(,=,:$6)'6)$(&.+7,D_'7.0.&/

- >)"(/%6/,D/,(+*/)

MONOGRAPHIE QUINQUINA ROUGEMONOGRAPHIE QUINQUINA ROUGE

88<88< K,8k80K,8k80ZZ-- D$"&320.:$%/,bF\,MD$"&320.:$%/,bF\,M

;7&).$&,630')'#'):$9+/,;7&).$&,630')'#'):$9+/,FF]":'$%(,F,,9+$%$%/@,9+$%$D$%/@,6$%63'%$%/@,]":'$%(,F,,9+$%$%/@,9+$%$D$%/@,6$%63'%$%/@,6$%63'%$D$%/6$%63'%$D$%/6$%63'%$D$%/6$%63'%$D$%/

~$(+.0$(.&$'%~$(+.0$(.&$'% U~,U~,5+$(,5+0?")$(.&$'%,5+$(,5+0?")$(.&$'%,D_.6$D/,D_.6$D/,#'):$9+/#'):$9+/

>+0?")$(.&$'%,>+0?")$(.&$'%,)".6&$#,$'D'50.&$%.&/)".6&$#,$'D'50.&$%.&/&.63/(,?$'0/&&/(,F,,9+$%$%/,j#,0/,50+(,*.(,F,&.63/(,?$'0/&&/(,F,,9+$%$%/,j#,0/,50+(,*.(,F,

/%&)/,O@\O,/%&)/,O@\O,-- O@QWO@QW

j".6&$'%,/%,&+*/,j".6&$'%,/%,&+*/,F,63.+##.H/,D/,0.,5'+D)/,F,63.+##.H/,D/,0.,5'+D)/, H'+&/00/&&/(,)'+H/,H'+&/00/&&/(,)'+H/,(+),0/(,(+),0/(,5.)'$(,F,5.)'$(,F,530'*.534%/(530'*.534%/( #0+')/(6/%6/,*0/+,/%,U~,#0+')/(6/%6/,*0/+,/%,U~,

9+$%$%/

9+$%$D$%/6$%63'%$%/

6$%63'%$D$%/

EMPLOIS DES QUINQUINASEMPLOIS DES QUINQUINAS

A+$%9+$%.,)'+H/,A+$%9+$%.,)'+H/,F,/:50'$,:"D$6$%.0,)"D+$&,D.%(,F,/:50'$,:"D$6$%.0,)"D+$&,D.%(,0/(,"&.&(,#"*)$0/(,/&,H)$55.+7,/&,/%,3':"'5.&3$/0/(,"&.&(,#"*)$0/(,/&,H)$55.+7,/&,/%,3':"'5.&3$/

5'+),(&$:+0/),.55"&$&,/&,5)$(/,D/,5'$D(,K~fM5'+),(&$:+0/),.55"&$&,/&,5)$(/,D/,5'$D(,K~fM

D":.%H/.$('%( /& "&.&( 5/00$6+0.$)/( K+(.H/ /7&/)%/MD":.%H/.$('%( /& "&.&( 5/00$6+0.$)/( K+(.H/ /7&/)%/MD":.%H/.$('%(,/&,"&.&(,5/00$6+0.$)/(,K+(.H/,/7&/)%/MD":.%H/.$('%(,/&,"&.&(,5/00$6+0.$)/(,K+(.H/,/7&/)%/M

A+$%9+$%.,/%,H"%").0,A+$%9+$%.,/%,H"%").0,K\O,OOO,&'%%/(|.%M,F,K\O,OOO,&'%%/(|.%M,F,

WO,X,$%D+(&)$/,.H)'WO,X,$%D+(&)$/,.H)'--.0$:/%&.$)/,K.5")$&$#(@,I&'%$6(IM,,,,.0$:/%&.$)/,K.5")$&$#(@,I&'%$6(IM,,,,

/7&).6&$'%,D/,0.,9+$%$%/,/7&).6&$'%,D/,0.,9+$%$%/,

Thomas DI PASCOLI

Acetate d'ethyle - toluene - diethylamine dans la nouvelle monographie.

>.0+D$(:/,F>.0+D$(:/,F.6&$?/,(+),#'):/(,$%&)..6&$?/,(+),#'):/(,$%&).--")2&3)'62&.$)/(,K(.+#,(63$e'%&/(,.H"(M")2&3)'62&.$)/(,K(.+#,(63$e'%&/(,.H"(M

.6&$?/,(+),0/(,N,>0.(:'D$+:,.6&$?/,(+),0/(,N,>0.(:'D$+:, 3'::/3'::/

$%.6&$?/,(+),#'):/(,/7'$%.6&$?/,(+),#'):/(,/7'--")2&3)'62&.$)/(,F,(5')'e'C&/(@,&)'53'e'C&/(,,")2&3)'62&.$)/(,F,(5')'e'C&/(@,&)'53'e'C&/(,,/&,H.:"&'62&/(/&,H.:"&'62&/(

PROPRIETES PHARMACOLOGIQUES PROPRIETES PHARMACOLOGIQUES DE LA QUININEDE LA QUININE

<"6.%$(:/,F,<"6.%$(:/,F,$%3$*$&$'%,D/,0.,(2%&34(/,5)'&"$9+/,D+,5.).($&/,5.),*0'6.H/,D/,0.,$%3$*$&$'%,D/,0.,(2%&34(/,5)'&"$9+/,D+,5.).($&/,5.),*0'6.H/,D/,0.,D"H).D.&$'%,D/(,.:$%'.6$D/(,D/,0J3":'H0'*$%/,D/,0J")2&3)'62&/D"H).D.&$'%,D/(,.:$%'.6$D/(,D/,0J3":'H0'*$%/,D/,0J")2&3)'62&/$%3$*$&$'%,5'02:")$(.&$'%,34:/,/%,3":'e'C%/,%'%,&'7$9+/$%3$*$&$'%,5'02:")$(.&$'%,34:/,/%,3":'e'C%/,%'%,&'7$9+/&'7$6$&",5'+),0/,5.).($&/&'7$6$&",5'+),0/,5.).($&/

<2'6.)D/,<2'6.)D/,F,F, /76$&.*$0$&"@,6'%D+6&$*$0$&"@,6'%&).6&$*$0$&"/76$&.*$0$&"@,6'%D+6&$*$0$&"@,6'%&).6&$*$0$&"

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;:50'$,D/,0.,9+$%$%/,.+P'+)DJ3+$,F;:50'$,D/,0.,9+$%$%/,.+P'+)DJ3+$,Fj"(/)?",.+7,6.(,("?4)/(,D/,:.0.)$.,=,j"(/)?",.+7,6.(,("?4)/(,D/,:.0.)$.,=,P. falciparumP. falciparum

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INTRODUCTIONINTRODUCTION

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INTRODUCTION

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TAXOÏDESTAXOÏDES

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COMPOSITION CHIMIQUECOMPOSITION CHIMIQUE

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