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Tableau I. Aurora kinase A et N-Myc, nouveaux “drivers” de la prolifération. Figure 1. Aurora kinase A et N-Myc, nouveaux “drivers” de la prolifération ?. Cancer neuro-endocrine de la prostate. Adénocarcinome de la prostate. +. N-Myc. Aurora kinase A. +. +. - PowerPoint PPT Presentation
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La Lettre du CancérologueCorrespondances en Onco-Urologie
Tableau I. Aurora kinase A et N-Myc, nouveaux “drivers” de la prolifération
TotalAurora kinase A
IHC (%)
Aurora kinase A Amplification
(%)
N-MycAmplification
(%)
Tissu bénin prostatique 22 0 0 0
Cancer de la prostate 117 12 6 5
Cancer neuro-endocrine de la prostate (NEPC)
29 76 38 42
La Lettre du CancérologueCorrespondances en Onco-Urologie
Figure 1. Aurora kinase A et N-Myc, nouveaux “drivers” de la prolifération ?
Adénocarcinomede la prostate
N-Myc
Cancer neuro-endocrine de la prostate
Aurora kinase A
Prolifération cellulaireSpindle Checkpoint Override
Regulation of DownstreamTarget Genes
MétastaseWnt/βCatenin
Glycolyse
Prolifération cellulaire
↓ DKK1
+
++
CCNL2-AURKA IP3Gène fusion
![The Transcription Factor Encyclopediagero.usc.edu/labs/benayounlab/files/2018/06/...(MYC) [3], the pervasive roles of TFs are becoming increasingly appreciated and experimentally character-ized](https://img.pdfslide.fr/doc/110x75/60b2840cfef7155f3624d16b/the-transcription-factor-myc-3-the-pervasive-roles-of-tfs-are-becoming.jpg)
