Le CRNH-IdF

Centre de Recherches en Nutrition Humaine

d’Ile de France

Alain GRYNBERG

Clinical investigation

Basic science

CV risk diabetes

(Jean Verdier)

Food economy (INRA)

Obesity centergenotyping

(La Pitié)

Gut, satietydigestion

CRV(Avicennes)

Epidemiology(INRA-INSERM-Paris13)

Protein, satiety digestion (INRA, AgroParisTech)

Adiposetissue

(INSERM, Paris 6)

150<employees<200

Publications>100/y

URA 1303 ALISS LG SolerINRA Ivry

Gastroenterology-Hepatology

R BenamouzigAVC-UP13

CRVR Benamouzig

AVC-UP13

NutritionJM OppertLPS-UP6

Genotyping K ClémentAmbulatoryExplorationJM Oppert LPS-UP6

Endocrinology-diabetology-

NutritionP ValensiJV-UP13

UMR Inserm U872K Clément

UP6

U914D Tome

Agroparistech

Endocrinology-Diabetology

G Reach AVC-UP13

COPILScientificcouncil

Direction

UMR U557 /U1125

S Hercberg SMBH-UP13

Gut, satiety

Obesity / AdT

compliance

Risk factors

Clinicalinvestigations

Epidemiology Economy

Scientific Activity 1

Dietary behaviour &food consumption

General population

Specific populations

Variability

Typologies

dietary behaviour and consumption

children, elderly, socio-demographic and socio-economic categories, diseased populations

evolution of behaviour , regional variations

food consumption data collection & new tools design, methodology for global nutrition and creation of dietary typologies

Scientific Activity 2

Determinant factors of behaviour on food consumption

& nutritional status

economical

social

sensorial

psycho-physiological

physio-pathological

costs vs nutritional quality, socio-economic level, food supply vs demand

taste training, food acceptability, lifestyle, life cycles, …

hunger & satiety, satiety in the course of meal, attitudes and beliefs, energy density in food, portion size, conviviality & stimuli

initiation and stop of eating, mechanisms of nycthemeral periodicity; conditioning and training

physical activity, physiological and pathological situations

Scientific Activity 3

Dietary behaviour & health

Quality of life

Physiological functions

Risk factors

Morbi-mortality

Interactions genetic factors / risk factors / behaviour

hormonal, cardiovascular, adipose, digestive

overweight, HTA, dyslipidemia, metabolic syndrome

Prevention strategies

Market & behaviour

Social marketing of information

Transfer to population

• Effects of information on behaviour & corpulence

• Effects of information and product characteristics on food choices

• Education strategies for health considering population specificities.

• Compliance to nutritional recommendations

Scientific Activity 4

Main clinical explorations availablein Paris-13 sites

Indirectcalorimetry

stable isotope tracers

biphotonicabsorptiometry

AvicennePr R Benamouzig, Dr G Airinei

Gastro-entero-hepatology

300 m2 heavy clinical explorationBody composition Ambulatory and resting energy expenditureQualitative and quantitative analysis of dietary behaviourMetabolic & hormonal profile Behaviour study boxes Intestinal perfusion coupled to stable isotope tracers Gut motility and gastric emptying (stable isotopes-echography) Digestive tract biopsies, faecal and colonic flora

Main clinical explorations availablein Paris-13 sites

Jean Verdier HospitalPr Paul Valensi, Pr Emmanuel Cosson

Endocrinology, CV risk factors

Body composition Ambulatory and resting energy expenditure Qualitative and quantitative analysis of dietary behaviour Metabolic & hormonal profile Insulin-resistance coupled to calorimetry Insulin secretion and sensibility to insulin Peripheral endothelial function, artery compliance and CV autonomic activity CV activity & echocardiography Non invasive AGE measurement Continuous glycaemic profile (G-Holter)

Microcirculation by laser doppler

Arterial compliance endothelial function

Body composition

Main clinical explorations available in Paris 6 site

La Pitié SalpétrièrePr JM Oppert, Pr K. Clément

Obesity, adipose tissue

Unit of ambulatory exploration in obesity Ambulatory and resting energy expenditure Body composition Qualitative and quantitative analysis of dietary behaviour Metabolic & hormonal profile Exercice training for obese patients Adipose tissue phenotyping Functional genomic Genetic epidemiology, mutations & polymorphisms

The Projet : Phenotyping Harmonization

Body composition

Hormonal & metabolic profile

endothelialfunction

glycaemicprofile

Free livinginvestigations

technicalprotocols

& equipmentharmonization

CRNH IdF

AVC

LPS

JV

AVC

LPS

JV

IdF

Auvergne

OuestRhoneAlpes

The Projet : Scientific Development

Diabetes, CVD •Subclinical cardio-vascular changes in the alterations of vago-sympathetic balance in prediabetes •Postprandial changes in the vago-sympathetic balance across the glycemic continuum from normoglycemia to prediabetes and diabetes•Geographic origin, psycho-social deprivation and diet as predictive factors for gestational diabetes mellitus

Digestion, Satiety•Microbiota•Quality of the source of proteins

Obesity•Microbiota